Biomolecular designer; currently postdoc @UWproteindesign; starting my lab @ISTAustria in March 2024 @flopraetorius.bsky.social

Seattle
Joined January 2023
Exciting news part 2: I’m honored and delighted to announce that the Praetorius lab for Biomolecular Design @ISTAustria has been awarded an #ERCStG (before even starting) for “Design of Nucleic Acid-templated Ordered Protein Assemblies”. @ERC_Research
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Florian Praetorius retweeted
Anna and Sam are X-less but they’ve done some excellent work with this project. It’s a very exciting time for enzyme designers!
New research in Science represents a notable step forward in designing enzymes from scratch. With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins. Learn more: scim.ag/4hU7O1H
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Florian Praetorius retweeted
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis or other (non-LCH) histiocytic sarcomas cases. I'm trying to understand non-surgical chemo and targeted therapy options, new pathology markers to better diagnose subtypes/treatments, and any data on progression in pediatric patients. Please feel free to share – I’m trying to cast a wide net due to the rarity of this condition and how little is known. People can contact me directly at my first name (as written in my profile) at octant.bio.
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Florian Praetorius retweeted
“Science is a human activity.” The week before chemistry laureate David Baker visited Stockholm to receive his Nobel Prize, his 101st PhD student had just graduated from his lab. For Baker, doing great science is about collaboration – he puts great effort into fostering a diverse, vibrant and sociable community of scientists that he works with. One hundred and thirty of those students and researchers joined him in Stockholm – perhaps the ultimate lab celebration! More about Baker and the 2024 Nobel Prize in Chemistry: bit.ly/4iz7B56
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Florian Praetorius retweeted
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.1101/…
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Florian Praetorius retweeted
Finally, out in @ScienceMagazine today, our work on de novo protein design. Together with @HattoriLab , @sokrypton & @hendrik_dietz we showed how we can drastically improve AF2 based hallucination, surpassing, or reaching SOTA diffusion models doi.org/10.1126/science.adq1…
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Florian Praetorius retweeted
Excited to join the Gene Center at LMU @GeneCenter_LMU @LMU_Muenchen as a professor, looking forward to design some cool and unusual de novo proteins here!
🥳 We welcome Lukas Milles as new group leader🤗🤗! Since July 2024, he's leading an Emmy Noether Research Group at MPI Biochemistry, now also affiliated with us! 💻🧪 His work focuses on protein design, deep learning & biophysics. genzentrum.uni-muenchen.de/r… @LFMilles @MPI_Biochem
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Florian Praetorius retweeted
I am looking for a partner in crime who actually understands biology in Vienna — join Aithyra to make some magic oeaw.ac.at/aithyra/news/sear…
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Florian Praetorius retweeted
Three @ISTAustria scientists have won @erc_research Starting Grants #ERCStG! A combined 4.8 million euros will go to @MMondelli, @aliciakmichael, and @lisa_Bugnet. Read more about the scientists and their projects 🔗 bit.ly/3XvfQXo
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Hot off the press: New paper about computational design of oligomeric proteins that can be triggered to change size and shape through allostery. Check out the beautiful thread by @ArvindSPillai1 !
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