@FloChardon

Scientist and computational biology team lead at the Seattle Hub for Synthetic Biology at the Allen Institute. PhD with @JShendure and @lea_starita.

 Seattle, WA
alleninstitute.org/division/seattle-hub-for-synthetic-biology/seattle-hub-team/
Joined February 2014
  • Tweets424
  • Following254
  • Followers507
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News & Views article by Jesse and Alex on our RA-gastruloid model! Big thanks to @alex_schauer_ and @jvveenvliet for their insightful summary of our RA-gastruloid paper. The article also provides an overview of current stem-cell-based embryo models (SEMs) fields and future directions with beautiful images. Highly recommended for anyone interested in the latest developments in SEMs! nature.com/articles/s41556-0…
jesse veenvliet @jesseveenvliet.bsky.social@jvveenvliet10 Oct 2024
📢 Check out our @teamstembryo @NatureCellBio News & Views with postdoc @alex_schauer_ on the latest feat in human stem-cell-based embryo models by @Nobu_Hamazaki, @JShendure & colleagues. Full text: rdcu.be/dWw3c nature.com/articles/s41556-0… #gastruloids
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Another opportunity @StJudeResearch! Seeking a senior scientist 👨‍🔬👩‍🔬to lead a brain #organoid core to support researchers in Ctr for Peds Neuro Dz Res - collaborative work with multiple PIs to understand & treat #RareDisease 🧠🧬 talent.stjude.org/research/j…
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Excited to share our human RA-gastruloid model in @NatureCellBio! Early retinoic acid supplementation, followed by later Matrigel addition, robustly induces human embryonic morphologies and diverse cell lineages, including somitic, renal, cardiac, and neural cell types in #gastruloid. rdcu.be/dRtj9
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What do microhabitat suitabilities above range edges tell us about potential species distribution shifts?! Huge thank you to @rangelimits @katie_gwin and others for this fun collaboration while a PostDoc at @UBCBiodiversity! doi.org/10.1111/ecog.07144
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We're so excited to continue our collaborative work with @CarvillLab and @curechd2 on the CHD2 episignature. Thx to @ebonkowski @cwlaflamme @edith_almanza_ for leading the way on the actual work and to @CureEpilepsy for partnering to fund this. 🧬🧠🧬
Coalition to Cure CHD2@curechd210 Jun 2024
Congrats to @hcmefford for Rare Epilepsy Partnership Award to study the methylation signature of CHD2-related disorders to help clarify VUS Dx + predict CHD2 symptoms & traits. @CureEpilepsy & @curechd2 are joint partners, co-funding this grant to accelerate CHD2 research
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Our DNA Typewriter protocol (written by @LiaoHanna, @JShendure, and myself) is out! Thank you @NatureProtocols for writing/editing this with us and having it as this week’s #FeaturedProtocol :-)
Nature Protocols@NatureProtocols11 Jun 2024
#FeaturedProtocol this week from Jay Shendure on using #DNATypewriter (#primeediting-based method) for tracing insertional events bit.ly/4cegahU
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scQers are quantitative single cell expression reporters reported by @JShendure and colleagues. They enable high-sensitivity quantitative characterization of developmental cis-regulatory elements at the single-cell level. nature.com/articles/s41592-0…
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After a constructive set of reviews, our single-cell reporter work is OUT nature.com/articles/s41592-0… Check out the briefing if you want the tldr nature.com/articles/s41592-0… I am particularly fond of some of the new applications. Mini-update.
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Flo Chardon retweeted
Alice Berger@aliceb_phd8 Apr 2024
Exciting day for the #BergerLab at #AACR24! First up it’s my talk in Ballroom 6C. I’ll be presenting our work with @FloChardon @lea_starita @JShendure on discovery of EGFR inhibitor resistance mutations using multiplexed prime editing.
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What if we could inducibly create thousands of structural variants and ecDNAs in human cells and see which ones survive? biorxiv.org/content/10.1101/… I’m excited to share our story on scrambling the human genome by combining prime editing, repetitive elements, and recombinases. A🧵
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Structural variants (SV) impact more nucleotides per human genome than other forms of genetic variation. To better understand SV impact, we developed a method to 'shuffle' mammalian genomes and characterize them with single-cell resolution in a pool. biorxiv.org/content/10.1101/…
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This was the most fun journey with the best team&friends. @FlorianIngelfi1 @CuriousKX @kathleenabadie @AssafWeiner Yonatan @IdoAmitLab
IdoAmitLab@IdoAmitLab21 Dec 2023
We are very excited to present the development of Zman-seq (“Zman”, Hebrew for “time”), the 1st technology that measures single-cell transcriptomes and physical time in vivo, led by @D_Birschenkaum, @CuriousKX, @FlorianIngelfi1, @AssafWeiner sciencedirect.com/science/ar…. (1/19)
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Robin Aguilar has been selected as the artist for the 2023 SACNAS conference! s6.goeshow.com/sachn/ndsc/20…
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It’s official! Faculty search opening this fall! We are looking to hire multiple faculty across the human genetics research spectrum! Looking forward to you joining us!!
Institute for Human Genetics at UCSF@IHG_at_UCSF5 Jun 2023
Check out the #IHG at #UCSF's Newsletter Spring & Summer 2023 edition for all the latest messages, news, profiles, publications, events and more! Please contact @IHG_at_UCSF to join our 📧distribution list. conta.cc/3Ivw3nx 🧬🧪🥼🔬
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Stoked to be in Montreal for #canacn2023 to present my work with @FloChardon and co. In the @JShendure lab on multiplex single cell CRISPRa screens! surl.li/hkkno Also stoked to be in Canada, where everyone, including the skatepark locals are “NICE”! @CAN_ACN
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Flo Chardon retweeted
Rajiv McCoy@rajivmccoy25 May 2023
I am happy to share teaching materials from our undergrad computational course on human genetic variation for other students and instructors to use and adapt. This was developed by @smyan__ with help from @KjweavI and me, supported by @JHU_CTEI. mccoy-lab.github.io/hgv_modu…
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For those on #Twitter interested in #BioTech, #CRISPR & #GeneEditing - here’s a must lecture given by one the top leading #scientists & #innovators of our time - @davidrliu, in which he explains the #Science & the future applications of #BaseEditing & #PrimeEditing. $BEAM $PRME
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We're hiring a senior scientist to tackle the challenge of assaying 10,000s of human variants across diverse cellular models. 🧬 ✂️🧪✂️ 🧬 crick.ac.uk/careers-study/va… Please RT + DM if interested.
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Flo Chardon retweeted
Jay Shendure@JShendure6 Apr 2023
Excited to share our lab's latest preprint, led by @CXchengxiangQIU, @bethkarenmartin & Ian Welsh of @jacksonlab. We set out to build a single cell roadmap for all of mouse prenatal development, from single cell zygote to free-living pup. Preprint: tinyurl.com/2nhe4mm9 1/n
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Co-founder & Head of our Prime Editing platform, Andrew Anzalone, is looking forward to presenting on Prime Editing for Therapeutic Applications today at the Functional Genomics of Human Brain Development & Disease @GordonConf. Learn more about the event: grc.org/functional-genomics-…
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