Scientist and computational biology team lead at the Seattle Hub for Synthetic Biology at the Allen Institute. PhD with @JShendure and @lea_starita.
Seattle, WA
Joined February 2014
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I spent my PhD developing novel genomic technologies, and today I am extra excited to share the last bit of this work, which is a multiplex prime editing (PE) screening framework! (1/n) biorxiv.org/content/10.1101/…
I have only amazing things to say about @sdomcke - her lab will be one of the best out there, both from a scientific and mentorship perspective. I can't wait to visit!
Flo Chardon retweeted
News & Views article by Jesse and Alex on our RA-gastruloid model! Big thanks to @alex_schauer_ and @jvveenvliet for their insightful summary of our RA-gastruloid paper. The article also provides an overview of current stem-cell-based embryo models (SEMs) fields and future directions with beautiful images. Highly recommended for anyone interested in the latest developments in SEMs!
nature.com/articles/s41556-0…
📢 Check out our @teamstembryo @NatureCellBio News & Views with postdoc @alex_schauer_ on the latest feat in human stem-cell-based embryo models by @Nobu_Hamazaki, @JShendure & colleagues. Full text: rdcu.be/dWw3c nature.com/articles/s41556-0… #gastruloids
Exciting times!!!
Incredibly proud to share that I recently joined @UCSF_BTS @UCSF as an Assistant Professor! This means that the Calderon Lab is now open!
Or, more accurately, in the process of opening as I am still unboxing equipment and unraveling giant posters (a last @JSHendure lab gift) 🥳
ALT Me outside my lab building holding my UCSF badge
ALT Unraveling a giant poster that says "Calderon Lab est. 2024"
Another phenomenal piece of work from a superstar postdoc and my closest collaborator @TroyMcDiarmid, & incredible (now PhD student!) Megan Taylor! Megan joined the lab as a freshman undergrad, & it has been nothing short of amazing watching her develop into an amazing scientist.
Beyond stoked to share our latest, entitled “Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording” !
biorxiv.org/content/10.1101/…
Genomic tech dev is my favorite area of science, and today our paper describing our multiplex CRISPRa screening method to identify cell type specific regulatory elements is published! rdcu.be/dUnoq
I also feel lucky that my interests outside of lab aligned so well with so many Shendure lab members! How special is it to have labmates that will go skiing with you before work? :) (also pictured is @sdomcke, another wonderful collaborator)
Thanks @JShendure for the second-to-none mentorship and scientific guidance, and a big thank you to @NadavAhituv for your guidance and prudent insights in regards to the development of this method and work!
Flo Chardon retweeted
Another opportunity @StJudeResearch! Seeking a senior scientist 👨🔬👩🔬to lead a brain #organoid core to support researchers in Ctr for Peds Neuro Dz Res - collaborative work with multiple PIs to understand & treat #RareDisease 🧠🧬
talent.stjude.org/research/j…
Flo Chardon retweeted
Excited to share our human RA-gastruloid model in @NatureCellBio! Early retinoic acid supplementation, followed by later Matrigel addition, robustly induces human embryonic morphologies and diverse cell lineages, including somitic, renal, cardiac, and neural cell types in #gastruloid. rdcu.be/dRtj9
So, so proud of @wchenomics. I have all the respect in the world for Will and his devotion to seeing this through to the end! This represents an absolutely enormous amount of experiments and high quality science. Congrats!
Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously.
nature.com/articles/s41586-0…
Flo Chardon retweeted
What do microhabitat suitabilities above range edges tell us about potential species distribution shifts?! Huge thank you to @rangelimits @katie_gwin and others for this fun collaboration while a PostDoc at @UBCBiodiversity! doi.org/10.1111/ecog.07144
Flo Chardon retweeted
We're so excited to continue our collaborative work with @CarvillLab and @curechd2 on the CHD2 episignature. Thx to @ebonkowski @cwlaflamme @edith_almanza_ for leading the way on the actual work and to @CureEpilepsy for partnering to fund this. 🧬🧠🧬
Congrats to @hcmefford for Rare Epilepsy Partnership Award to study the methylation signature of CHD2-related disorders to help clarify VUS Dx + predict CHD2 symptoms & traits. @CureEpilepsy & @curechd2 are joint partners, co-funding this grant to accelerate CHD2 research
