bigDNA/synBio/soccer/food/heavymetal
Seattle
Joined April 2010
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How much of the human genome is essential?
Two pieces out today from our lab: 1) a method to map essential genomic intervals at gigabase scale, and 2) an argument that it's time to consider synthesizing a minimal human genome.
biorxiv.org/content/10.64898…
nature.com/articles/d41586-0…
Excited to share Shotgun Genetic Engineering, developed by @julie_trolle, out in @NatureBiotech!
Read on to learn how Julie enabled mammalian cells to grow without 2 essential amino acids for the first time in >500 million years using highly multiplexed metabolic engineering!
Highly multiplexed mammalian metabolic engineering with a shotgun approach - @sudpinglay @JefBoeke nature.com/articles/s41587-0…
also big thanks to @BashorLab @kshitij_raiguy for a fantastic news and views article on the paper!
nature.com/articles/s41587-0…
So excited about Anthropic’s release of MHS. Read how Zihao Song got multiple devices in our lab talking to one another, including coordinating a plate dispense and handoff using a robotic arm.
A cathartic experience for anyone who has dealt with lab automation!
Today, we're kicking off the first phase of the research preview for Model Hardware Standard (MHS): a new standard for AI agents to safely operate physical equipment in scientific research and advanced manufacturing.
Read more: anthropic.com/news/model-har…
Sudarshan Pinglay retweeted
Following the publication of our phage gen paper, I wrote some personal thoughts on biosafety and biosecurity as generative biology improves.
Given the trajectory of progress, there should be concern and urgency -- but also optimism.
brianhie.com/present_and_fut…
Sudarshan Pinglay retweeted
Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote
1/n
Looking forward to engaging further with the community on these ideas.
If you're excited about working in these areas, we are hiring!
pinglay-lab.com/
huge thank you to all the co-authors and in particular, @JonasKoeppel @JShendure for helping leading this effort!
also big thanks to @BrotmanBaty @NIH_CommonFund @genome_gov @biohub @DARPA for funding!
Sudarshan Pinglay retweeted
1/n What fraction of the human genome is essential for cellular viability?
Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads.
@sudpinglay @JShendure
biorxiv.org/content/10.64898…
