@diegoisworking

Assistant Professor @UCSF_BTS | @CZBiohub – SF Investigator

Joined October 2013
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  • Following624
  • Followers736
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Incredibly proud to share that I recently joined @UCSF_BTS @UCSF as an Assistant Professor! This means that the Calderon Lab is now open! Or, more accurately, in the process of opening as I am still unboxing equipment and unraveling giant posters (a last @JSHendure lab gift) 🥳
Me outside my lab building holding my UCSF badge

ALT Me outside my lab building holding my UCSF badge

Unraveling a giant poster that says "Calderon Lab est. 2024"

ALT Unraveling a giant poster that says "Calderon Lab est. 2024"

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Diego Calderon retweeted
Jay Shendure@JShendureOct 8
Exciting day for DNA Typewriter w/ 2 papers from the lab & SeaHub out today :) 1. Mouse lineage from E0 to E13.5 science.org/doi/10.1126/scie… 2. A fluctuation test for gastruloid heterogeneity cell.com/cell/fulltext/S0092… Paper #1 covered in quoted thread. More on paper #2 here. 1/n

A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis

Mammalian biology unfolds over time, within tissues and organs opaque to our eyes and instruments. We applied DNA Typewriter, a sequential molecular recorder, to record the cell lineage of a mouse...

science.org
Jay Shendure@JShendureJul 31
Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n
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Seth Shipman@seth_shipmanSep 29
My department at UCSF is hiring new faculty focused on biomolecular engineering. If that's how you think of yourself, apply! It's a great place to be a scientist. aprecruit.ucsf.edu/JPF06213

BTS Biomolecular Engineering Faculty Recruitment

University of California, San Francisco is hiring. Apply now!

aprecruit.ucsf.edu
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Diego Calderon retweeted
Brunilda Balliu@brunilda_balliuMay 21
1/ Our new paper is out in @CellGenomics 🎉 We introduce FastGxC, a fast and powerful method for mapping eQTLs in bulk and single cell sequencing studies and quantifying how their effects vary across tissues and cell types. cell.com/cell-genomics/fullt…

FastGxC: Fast and powerful context-specific eQTL mapping in bulk and single-cell data

Krockenberger, Lu, et al. introduce FastGxC, a method that identifies how genetic variants regulate gene activity in specific tissues and cell types more efficiently than existing approaches. Applied...

cell.com
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Diego Calderon retweeted
Junyue
@junyue_caoApr 16
🚀Excited to share our new paper @Nature! We developed PerturbFate platform to discover how diverse genetic perturbations converge on a shared cell state, and key molecular programs driving it, led by our incredible student @xu_zxu from @RockefellerUniv. rdcu.be/fdC14
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Aki Ushiki@AkiUshikiApr 10
Our bat–mouse limb paper is now on bioRxiv! 🦇🧬biorxiv.org/content/10.64898… This was a collaborative effort across the @NadavAhituv, @NicolaIlling, @DoritHockman, Guy Kelman, Tommy Kaplan and my lab at @WashUGenetics Highlights below ↓
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Chengxiang Qiu@CXchengxiangQIUApr 9
New preprint! @JShendure @CXchengxiangQIU Can we learn regulatory grammars of human cell types we'll never be able to profile - by training on mouse development and transferring across 241 mammalian genomes?biorxiv.org/content/10.64898…
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Troy McDiarmid@TroyMcDiarmidApr 2
Stoked to announce that I’m starting a lab as an Assistant Professor in the School of Biomedical Engineering and Centre for Brain Health at UBC! mcdiarmid-lab.sbme.ubc.ca Recruiting at all levels - please share the word! Cheers and happy long weekend all!
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UCSF Surgery@UCSFSurgeryFeb 5
‼️The @UCSF Broad Stem Cell Center & Department of #Surgery is recruiting faculty to help advance the future of Gene Editing. This position focuses on the Development of delivery tools for Gene Editing to enable cutting-edge gene therapies. Apply below👇aprecruit.ucsf.edu/JPF05914
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Rajiv McCoy@rajivmccoyJan 22
Pregnancy loss is common in humans, and chromosome abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that common variation in meiosis genes influences recombination and aneuploidy risk. @saracarioscia @aabiddanda nature.com/articles/s41586-0…

Common variation in meiosis genes shapes human recombination and aneuploidy

Nature - Analysis of data from pre-implantation genetic testing sheds light on the genetic basis of meiotic-origin aneuploidy, the leading cause of human pregnancy loss, identifying common genetic...

nature.com
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Ribosomal RNA (rRNA) genes are found in hundreds of copies in the human genome. Do sequence variations in these paralogs change the ribosome function? Yes! I am excited to share our new preprint @mbarnalab @jkpritch in collaboration with Calico: medrxiv.org/content/10.1101/… 1/8
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Thrilled to share I’ve started my lab at Dartmouth’s Geisel School of Medicine! We focus on mapping cellular trajectories & TF networks in development and Mendelian disorders, exploring new therapies. Join us—postdocs, grads, and scientists welcome! sites.dartmouth.edu/qiulab/
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Stoked to share our latest work entitled “Large-scale discovery of neural enhancers for cis-regulation therapies” shorturl.at/H3Qww This is an enormous team effort that I had the honour of spearheading with Nick Page and @FloChardon Tweetorial below.
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Online Now: Combinatorial mapping of E3 ubiquitin ligases to their target substrates dlvr.it/THqW1q
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Please re-tweet: We are hiring! Assistant Professor in statistical genetics. Also, hiring a postdoc. Reach out to hear more. Also, if you’ll be at #ASHG24 #ASHG2024, we could meet. careers.ashg.org/jobs/207625…
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Yi Fu@Yi__Fu20 Oct 2024
Excited to share my PhD work in @Agnelsfeir’s lab describing a method to engineer mitochondrial DNA deletions in human cells and our exploration of how cellular metabolism and transcription respond to deletion heteroplasmy. biorxiv.org/content/10.1101/… 1/19

Engineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria

Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled the precise introduction of base substitutions and the effective removal of genomes carrying harmful...

biorxiv.org
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Silvia Domcke@sdomcke17 Oct 2024
New synthetic biology / gene regulation lab opening in Zurich! We’re studying how to control cell state transitions – for example, making diseased cells healthy or creating new cellular functions – using systematic perturbations, single-cell genomics and machine learning. 🧵1/4
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Harold Pimentel@hjpimentel15 Oct 2024
This is happening tomorrow! Still some time to sign up! Both in-person and online opportunities! xitter.cf/hjpimentel/status/1844…
Harold Pimentel@hjpimentel10 Oct 2024
Interested in math and computational biology? The @CompMedUCLA PhD program is having our info session On Wed 16th at 3-4P PST. Come learn about our program and hear from some of our faculty. RSVP: forms.gle/qozQj6aEmc4PPnVWA

UCLA Biomathematics PhD Program Information Session Sign Up

Please sign up below to attend the information session! Date: Thursday, October 15th, 2026. Time: 4:00 PM to 5:00 PM pacific time. Location: The Tannas Alumni Room, First Floor, Engineering VI...

docs.google.com
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Diego Calderon retweeted
Ryan Hernandez@rdhernand15 Oct 2024
Thinking about a PhD using computational power to answer pressing problems in biology and health? @UCSF Biological and Medical Informatics PhD program is recruiting for Fall 2025! Join our info session next Monday Oct 21: bmi.ucsf.edu/admissions.
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First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.1101/… (1)

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

Enhancers are critical genetic elements controlling transcription from promoters, but the mechanisms by which they convey regulatory information across large genomic distances remain elusive. Here,...

biorxiv.org
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