@FaesenLab

Max-Planck Research Group at MPI for Multidisciplinary Science (@mpi_nat) | Autophagy initiation | Structural biochemistry | Reconstitution | Views are my own.

 Göttingen
Joined August 2018
  • Tweets223
  • Following259
  • Followers589
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Influence of ULK1 activity on the memory of ATG101 auto-activation dynamics biorxiv.org/content/10.1101/… #biorxiv_biochem

Influence of ULK1 activity on the memory of ATG101 auto-activation dynamics

The initiation of autophagy is marked by the prompt convergence of initiation proteins to form super molecular complexes in spatially-defined autophagic hubs. The recruitment and activation of the...

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Influence of ULK1 activity on the memory of ATG101 auto-activation dynamics biorxiv.org/content/10.1101/…
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FaesenLab retweeted
StorkLab@LabStork23 Sep 2024
Heading to Sorrento😊, #EMBOautophagy24
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Ivan Đikić@iDikic23 Sep 2024
Place to be for scientists studying quality control mechanisms in life processes. Impressive line-up of speakers. Thx to @HMWK_Hessen @EnableFrankfurt and @dfg_public @SFB1177. Students and postdocs are invited to apply for selected talks👍🤗 @goetheuni #ubiquitin #autophagy
Enable Cluster in Frankfurt@EnableFrankfurt3 Sep 2024
#FCQC2025: Registration open fcqc.de/ Join us for a high-caliber line-up of talks on quality control mechanisms & networks, the interplay of autophagy & ubiquitin in health & disease, novel therapeutics using the ubiquitin system. #proteostasis #autophagy
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PhD or postdoc position in biochemistry, biophysics & structural biology @FaesenLab! Join the project focusing on the reconstitution and structural-functional characterization of newly identified and purified macromolecular super-complexes. 👇 mpinat.mpg.de/4787445/27-24
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#PhD, #DnD(?) & #postdoc positions in “theory and methods for non-equilibrium atomistic simulations of complex #biomolecules” – Interested in theoretical and computational #biophysics? Check out the #JobAlert & apply here ⬇️: Shares welcome! #hiring #job mpinat.mpg.de/4588467/60-23?…
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🤔Ever wonder why Atg8 has a C-terminal overhang that is always cleaved? Why conserve it? In this mini piece on @JMolBiol Saskia dives into these questions. Thanks to @AutophagyAarhus and Prof. Hofmann for the collaboration! sciencedirect.com/science/ar…
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Model of the regulation of autophagosome biogenesis by AMPK. @BarnabaCarlo, @DavidGBroadbent, @jenscs83 et al. clarify AMPKs regulatory role in #autophagy and highlight its potential as a therapeutic target to reduce autophagy. hubs.la/Q02y6LsL0 #CellMetabolism #Cancer
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I am excited to share updated information. FINALLY, our paper has been published in eLife! What happens in autophagosomal maturation? We revealed that autophagosomal membranes become negatively charged by PI4P enrichment during maturation. elifesciences.org/articles/9…
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Eat less to live longer? #Autophagy degrades damaged or toxic cellular material to keep cells in good shape. We discovered how #ATG16L1 shapes phagophores. Our article was published today in @NatureSMB ! thanks to all the authors !! Check it out: nature.com/articles/s41594-0…
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Open position: We are hiring a postdoctoral fellow to work on autophagy and sleep in flies and rodents! Cell biology x systems neuroscience. Exciting collaboration with Charlotte Boccara lab @ChaBoccara #autophagy #Drosophila @WAutophagy @UniOslo_MED @NCMMnews @CanCell_UiO
NCMBM@NCMBMnews4 Apr 2024
📢@ChaBoccara and @KnVelsrud are #hiring a #postdoctoralfellow/#researcher for an exciting project in Cell Biology and Systems Neuroscience. Apply by June 4th to join @NCMMnews, part of @NordicEMBL and @UniOslo_MED vibrant research environment👇! jobbnorge.no//en/available-j…
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Are you interested in DNA replication, DNA repair or chromatin? Do you have a passion to find out how proteins function in these processes? Are you collaborative and ambitious? Check out these open positions in my lab (and @FMattiroli lab): hubrecht.eu/about-us/working…
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📢 The Louis-Jeantet Foundation is happy to announce the 2024 #LouisJeantetPrizes, awarded to DIRK GÖRLICH @mpi_nat and to CHARLIE SWANTON @CharlesSwanton @TheCrick @CR_UK @uclcancer CONGRATULATIONS! 👉jeantet.ch/en 👇 follow thread
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🚨We are happy to start off the year with Anuradha's first author publication in @emboreports ! If you want to know more about the role of Atg1, Atg11 and Atg13 in bulk autophagy initiation, look no further, this is the paper for you. embopress.org/doi/full/10.10…

Decoding the function of Atg13 phosphorylation reveals a role of Atg11 in bulk autophagy initiation

EMBO Reports - Autophagy is initiated by the assembly of multiple autophagy-related proteins that form the phagophore assembly site where autophagosomes are formed. Atg13 is essential early in this...

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📢 Special Issue! #Autophagy: From Yeast to Humans. 👩‍🔬Guest-editors: @TassulaPC & Michael Thumm ➡️ bit.ly/3NZNmjf 30 years ago, FEBS Letters published work by Yoshinori Ohsumi identifying the first yeast autophagy genes. Learn how the field has developed since then!
Cover of FEBS Letters Vol 598 No 1, Special Issue on Autophagy: From yeast to humans. Human U2-OS cells stably expressing EGFP-LC3B (green) were grown in fed conditions, fixed and stained with anti-p62/AF 547 antibodies (red) and DAPI (blue). A representative confocal laser-scanning microscopy image is shown. Courtesy of Carmen Julia Pastor-Maldonade, Proikas-Cezanne laboratory, Eberhard Karls University Tuebingen, Germany.

ALT Cover of FEBS Letters Vol 598 No 1, Special Issue on Autophagy: From yeast to humans. Human U2-OS cells stably expressing EGFP-LC3B (green) were grown in fed conditions, fixed and stained with anti-p62/AF 547 antibodies (red) and DAPI (blue). A representative confocal laser-scanning microscopy image is shown. Courtesy of Carmen Julia Pastor-Maldonade, Proikas-Cezanne laboratory, Eberhard Karls University Tuebingen, Germany.

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FaesenLab retweeted
Rink Lab@rinklab21 Dec 2023
Model system genome database manager (f/m/x) mpinat.mpg.de/4586336/58-23 We are hiring! If you are an experienced model system genome researcher looking for a long-term position with flexible work arrangements, this one might be perfect. Please RT!

Open Positions

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Happy to share our recent study with #JahnLab, harnessing the power #Minflux nanoscopy @Abberior, @tandfonline #cellbiology #synapses #autophagy #ultrastructure #vesicles #superresolution tandfonline.com/doi/full/10.…

ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals

In neurons, autophagosome biogenesis occurs mainly in distal axons, followed by maturation during retrograde transport. Autophagosomal growth depends on the supply of membrane lipids which requires...

tandfonline.com
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FaesenLab retweeted
GBM e.V.@GBM_eV21 Nov 2023
Check out the new @Spektrum_BIO issue! #YoungPI’s present their research! Get to know the members of the GBM #YoungInvestigators: John Weir @weir_science from Friedrich Miescher Laboratory Tübingen presents his research on Molecular mechanisms of #MeioticRecombination!
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I'm thrilled to share the latest work from my lab, showing that a bacterial anti-phage immune system encodes a ubiquitination pathway strikingly similar to our own! biorxiv.org/content/10.1101/… (1/12)

Bacterial antiviral defense pathways encode eukaryotic-like ubiquitination systems

Ubiquitination and related pathways play crucial roles in protein homeostasis, signaling, and innate immunity[1][1]-[3][2]. In these pathways, an enzymatic cascade of E1, E2, and E3 proteins conjug...

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FaesenLab retweeted
VanniLab@LabVanni4 Sep 2023
Let’s start the week in style: just out in Biorxiv one of the most important results from my lab, with the Reinisch lab @YaleMed: “Lipid scrambling is a general feature of protein insertases”. The title pretty much sums it up. Short 🧵(1/13). biorxiv.org/content/10.1101/…

Lipid scrambling is a general feature of protein insertases

Glycerophospholipids are synthesized primarily in the cytosolic leaflet of the endoplasmic reticulum (ER) membrane and must be equilibrated between bilayer leaflets to allow the ER and membranes...

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