@DouamLab

Our laboratory @BUMedicine @BU_tweets @NEIDL studies viral pathogenicity and immunogenicity.

 Boston, MA
bumc.bu.edu/microbiology/people/faculty/florian-douam-ph-d/
Joined October 2011
  • Tweets520
  • Following324
  • Followers342
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Douam Lab retweeted
NEIDL@neidl23 Jul 2024
“This result opens the door to assessing potentially multiple vaccines given as a single shot." -NEIDL's @DouamLab via @Forbes @MKortepeter forbes.com/sites/markkortepe…
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Congrats Jaii, Kohji and Nader for graduating and being part of our lab the past few years! We will miss you!
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Douam Lab retweeted
Mark G.@Grinstaff9 Jul 2024
Drs. Wong & Douam & our teams are excited to share our paper in @NatureBiotech reporting on how modified self-amplifying RNA (saRNA) enables potent low dose vaccines, because unlike mRNA, saRNA is functional for a month. rdcu.be/dM45t @BostonU_BME @neidl @BUCollegeofENG
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Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency go.nature.com/3RYbPHK
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Fantastic collaboration with the @Grinstaff lab and Wong Lab at BU now published in Nature Biotechnology. nature.com/articles/s41587-0…
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We found modified nucleotides compatible with self-amplifying RNA replication, opening new avenues for developing more potent RNA-based vaccines and therapeutics.
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@BU_Tweets @neidl @BUMedicine
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Thank you #ASV2024 @AmerSocVirol we had an awesome time at a fantastic conference!
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New pre-print from the lab🥳🥳!! Amazing team effort between @DouamLab, @BalazsLab and Christelle Harly's group in Nantes. Congrats to @DevinKenney10 for spearheading the work. biorxiv.org/content/10.1101/…

Resolution of SARS-CoV-2 infection in human lung tissues is driven by extravascular CD163+ monocytes

The lung-resident immune mechanisms driving resolution of SARS-CoV-2 infection in humans remain elusive. Using mice co-engrafted with a genetically matched human immune system and fetal lung xenogr...

biorxiv.org
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And that's a wrap for our 2023 Annual Retreat. Another great time with a fantastic team !
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Please check out our newest study deciphering diff. in signaling strength betw type I&III #interferon receptors science.org/doi/10.1126/scis… Outstanding work by @EmilyMesev + fantastic collaboration with the terrific @toettch ! Thanks to everyone involved! @PrincetonMolBio @Princeton

Membrane-proximal motifs encode differences in signaling strength between type I and III interferon...

An intracellular motif in type I interferon receptors ensures they signal more strongly than their type III counterparts.

science.org
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Excited to announce the lineup for the 4th International virtual seminars on #arbovirus biology. Investigators will present their research on a range of topics, from differing career stages and perspectives. Help spread the word with a retweet! All welcome! Starts 19th Oct.
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This week, we said good bye to Felix @Virolicious_FS, a visiting student from @lab_jouvenet who stayed with us this summer. It was great to have you with us Felix and we hope to see you again soon !
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Fantastic summer lab outing at the Boston Marina. We missed you @Giulia22203120 but we will do this again :)
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Please check out our newest study in which we characterized #hepatitis B and #HBV #HIV coinfections in dually humanized mice. onlinelibrary.wiley.com/doi/… Congrats to Glenn, Ben and James and thank you to everyone involved @PrincetonMolBio @IHVmaryland @DouamLab @NYUGSOM_Path

Persistent hepatitis B virus and HIV coinfections in dually humanized mice engrafted with human...

Chronic hepatitis B (CHB), caused by hepatitis B virus (HBV), remains a major medical problem. HBV has a high propensity for progressing to chronicity and can result in severe liver disease, includ...

onlinelibrary.wiley.com
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Hello Switzerland 🤩
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Douam Lab retweeted
Saeed Lab@drmohsan14 Apr 2023
Check out our latest work describing cell culture systems for the study of SARS-CoV-2. Congrats to @DaYuanChen1 @DevinKenney10 @Crittermechanic and @DouamLab sciencedirect.com/science/ar…
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Douam Lab retweeted
Saeed Lab@drmohsan14 Mar 2023
The Saeed lab is hiring a postdoc! We are looking for a highly motivated virologist to work on innate antiviral immune mechanisms. The details can be found in the attached file. Please RT!
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Douam Lab retweeted
Saeed Lab@drmohsan11 Jan 2023
Our recent work on SARS-CoV-2 has come out in @Nature. This study identifies spike and nsp6 as major proteins contributing to Omicron’s pathogenicity/attenuation. nature.com/articles/s41586-0…

Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation

Nature - Comparisons of a chimeric recombinant version of SARS-CoV-2, the ancestral SARS-CoV-2 strain and an Omicron isolate show that the attenuated virulence of Omicron is caused by mutations in...

nature.com
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And that's a wrap for the Douam Lab retreat 2022. So grateful to be working with such amazing people !!
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