Senior Editor @NatureSMB. Views and opinions are personal.
Joined May 2012
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I am on paternity leave but this work from @Anders_S_Hansen lab out @NatureSMB needs to be talked about. The authors provide absolute quantification of loops (CTCF, E-P, P-P, you name it) across the genome. nature.com/articles/s41594-0…
Dimitris Typas retweeted
@mileshuseyin and the lab have put together a comprehensive protocol for genome-wide Micro-C and for Region Capture Micro-C (RCMC) in @NatureProtocols :
nature.com/articles/s41596-0…
See also the GitHub for a user-friendly end-to-end computational pipeline: github.com/ahansenlab/MicroC…
New Article! Mapping 3D genome organization at nucleosome-scale with Micro-C and Region Capture Micro-C (RCMC) dlvr.it/TTWNB5
This work presents a structural breakthrough, alongside three associated recent Nature papers, in our understanding of cytoplamic lattices (CPLs) in mammalian oocytes. CPLs store degradative and poised cytoskeletal complexes that poise eggs. nature.com/articles/s41594-0…
This impactful work is thoughtfully highlighted and contextualised in what I found as a great News & Views by @OchsFena, found here nature.com/articles/s41594-0…
Dimitris Typas retweeted
Happy to see our work on defining a dependency map of short linear motifs out. We use base editing screens to install more than 80000 mutations into SLiMs in more than 4000 proteins to determine their contribution to cell fitness. nature.com/articles/s41594-0…
Dimitris Typas retweeted
🔥 Chem(bio) friends, this one is big!!
IRB Barcelona is opening a Group Leader position in Chemical Biology! 💜
If your research plan and vision are at the interface of synthetic chemistry, chemical biology, and biomedicine, please check the call!
👉recruitment.irbbarcelona.org…
A well-worth-your-time Comment by Dr. Edith Heard, of
@TheCrick, and Dr. Gitte Neubauer, one of the founders of Cellzome, now at GSK, is out @NatureSMB . They provide valuable insight into what makes a successful partnership between academia and industry.
nature.com/articles/s41594-0…
Tempted to add (more) METAL gifs, but we @NatureSMB are indeed glad to feature METALoci and the conceptual advance imparted by the study in our pages.
How is sex determined? How is it encoded in the #3Dgenome?
Happy to share my PhD work. Sex-determining 3D regulatory hubs identified w METALoci, a new genome spatial auto-correlation approach
With @jrotwitguez Capel Lab @mamartirenom @Dariloops
Thread 👇biorxiv.org/cgi/content/shor…
Late to the party, but I wanted to highlight a recent @NatureSMB paper by the Hajkova and Vaquerizas labs, which notably advances our understanding of how chromatin organisation regulates gametogenesis. Very enjoyable and insightful work!
nature.com/articles/s41594-0…
Mitosis is not a chromatin barren landscape after all. A very insightful study @NatureSMB by the lab of @Anders_S_Hansen tells an intriguing story nature.com/articles/s41594-0…. @MITdeptofBE has put together a nice summary too news.mit.edu/2025/surprising…
Our September @NatureSMB issue is out! nature.com/articles/s41594-0… We feature very interesting papers on ubiquitylation and degradation. Really excited to continue to serve the proteostasis and PTMs communities and publish conceptually insightful work.
Dimitris Typas retweeted
Great to see our work featured in @NatureSMB! Thanks @DimitrisTypas for your coverage! @LabBoke @DexeusMujer
A captivating read on a very interesting topic, the closer-than-anticipated relationship between ubiquitin and ADP-ribose just out @NatureSMB, nature.com/articles/s41594-0…
Dimitris Typas retweeted
In this Q&A with @NatureSMB, @RiceLaboratory and Yael David of @MSKCancerCenter comment on new work that advances the molecular understanding of and, potentially, the clinical arsenal against infection with Hepatitis B virus. #WorldHepatitisDay
nature.com/articles/s41594-0…
Dimitris Typas retweeted
New online! Q&A with Yael David and Charles Rice on using chromatin biology to understand hepatitis bit.ly/4nYQqwI
Dimitris Typas retweeted
Proud to share what we hope will be a reference study on human oocyte proteostasis. Young-donor eggs show globally reduced organelle activity vs. somatic cells, with an even steeper drop as they mature.
👇 for @zaffagg3 's detailed explanation
embopress.org/doi/full/10.10…
📣 Paper alert!! Excited to share the 2nd research paper from my time in the @LabBoke at @CRGenomica, out today in the @embojournal!
We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?"
We collaborated with @DexeusMujer and employed #healthy human oocytes freshly donated for heterologous IVF
1/
On vacation, but so happy this is out and very proud to have had this discussion. I hope that the @NatureSMB readers appreciate it.
And to top it all off, @DimitrisTypas @NatureSMB published today a fantastic Q&A with Charlie @RiceLaboratory @RockefellerUniv, and me discussing our recent Hepatitis B chromatin paper in @CellCellPress! Such an honor to share this space. 🙏🏻 @NobelPrize
nature.com/articles/s41594-0…
Insightful work with potential against henipaviruses out @NatureSMB; have a nice read if interested, nature.com/articles/s41594-0…
Dimitris Typas retweeted
A transcription balance required for genome stability 🧬⚖️
Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on @NatureSMB
#CryoEM #transcription nature.com/articles/s41594-0…
Scientists travel to work. Some continue to travel during their career, some set roots to an adopted country, some return. @NatureSMB will publish 5 pieces on those that returned. The first discusses Dr. Gomes Dias' return to Brazil. Touching+inspiring. nature.com/articles/s41594-0…