@LabBoke

Oocyte Biology and Cellular Dormancy Lab in @CRGenomica, Barcelona, led by Elvan Böke. Joint lab account; tweets by Elvan are signed EB.

 Barcelona, Spain
crg.eu/en/elvan-boke
Joined February 2021
  • Tweets606
  • Following370
  • Followers1.8K
57Media
What does an ovary actually look like as it ages—one oocyte at a time? We mapped >85,000 oocytes in >100 intact mouse ovaries, in 3D, across the reproductive lifespan. And the ovary turned out to be much more organized than we expected. 🧵 1/5 nature.com/articles/s43587-0…

Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve

Nature Aging - The spatiotemporal dynamics of the depletion of the ovarian reserve remain incompletely understood. Combining whole-ovary imaging, AI and modeling, the authors mapped over 85,000...

nature.com
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The ovary actively 'counts' its eggs, preparing the same proportion for ovulation, at different stages of life 📹 Arturo D’Angelo et al @LabBoke @CRGenomica in @NatureAging ➡️ bpod.org.uk/archive/2026/9/2…
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Learn more about the first-ever 3D map of an ovary and how it could reshape our understanding of fertility, menopause, and women's reproductive health. discovermagazine.com/the-fir…

The First 3D Map of an Ovary Suggests a Hidden System Controls Egg Activation

Learn more about the first-ever 3D map of an ovary and how it could reshape our understanding of fertility, menopause, and women's reproductive health.

discovermagazine.com
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La Barceloneta, el 1973. 📷Color original
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🗺️ First 3D map of ovary throughout reproductive lifespan reveals it counts its own eggs A new study published in @NatureAging by @CRGenomica researchers challenges the idea that ovaries are simply passive egg reservoirs @LabBoke #BISTCommunity 👉 bist.eu/first-3d-map-of-ovar…
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Happy Sunday with another issue of #cebooc! This weeks @LabBoke shows the dynamics of follicle depletion with age using whole 3D imaging of intact mouse ovaries: pubmed.ncbi.nlm.nih.gov/4258… Read the full issue for more exciting papers: biomed.news/bims-cebooc/2026… subscribe here: biomed.news/bims-cebooc Thanks @Bims_BiomedNews for preselecting!
🤖 Made with AI
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This work took a village and several disciplines: Led by the fantastic Arturo D’Angelo, with Daniel Franco-Barranco, Marco Musy, @jmduranse , James Sharpe, @nstroustrup1 & Ignacio Arganda-Carreras bringing together imaging, AI, statistics and mathematical modelling. 4/5
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And I somehow ended up the only woman on the author list of a paper about ovaries. 😅 Very proud of this team and what we built together. 5/5
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BökeLab retweeted
ShorterLab@ShorterLabJul 23
Exclusive: Death of girl in Chinese gene-editing trial was never made public | Science | AAAS science.org/content/article/…

Exclusive: Death of girl in Chinese gene-editing trial was never made public

Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals

science.org
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Keeping oocytes alive for decades is a massive challenge, but so is earning a PhD with the highest honors! 👏 Massive (belated!) congratulations to our PhD student, Dr. Devesh Bahety (@devbahety) for defending his thesis and receiving an excellent cum laude! 🥳🏆 @CRGenomica
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Desde la Fundación Banco Sabadell felicitamos a los dos premiados, @marcguellc y @garciadearquer, y agradecemos a todas las personas que nos han acompañado en esta nueva edición de los #PremiosBiomédicaCiencias. Una cita anual que reúne a la comunidad científica para reconocer la excelencia científica y su potencial de impacto social. #LaCulturadelTalento #Investigación
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Exactly my thoughts re the "unbiased" QED 1% list- this analysis puts it on firm footing. One thing not captured here is the prominence of well-established authors; that's what triggered me whether QED was really ranking the science OR signals assoc'd w/ scientific prominence- EB
Ran Blekhman@blekhmanJun 28
I wanted to like QED's new 1% preprint ranking. But the more I looked at the data, the more uncomfortable it made me. Here is my full peer review: open.substack.com/pub/blekhm…
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🏆 Introducing the inaugural Suzanne Eaton Awards for Physics of Life! 👨‍🔬We're thrilled to announce the 2026 recipients: L. Mahadevan @Harvard and Anna Erzberger @embl who will give their award lectures on 20. November. ➡️Read our announcement here: tud.link/cjm8t2
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Our new paper is out in @ScienceMagazine! We developed mice with reversible control of autophagy, and showed that restoring this pathway after its suppression reverses neuronal abnormalities and brain dysfunction, demonstrating the resilience of neurons. science.org/doi/10.1126/scie…

Reversible suppression of autophagy in a mouse model reveals neuronal resilience

Impairments in intracellular quality-control mechanisms, including autophagy, affect neuronal integrity and function. Despite numerous studies aimed at slowing neuronal deterioration, it remains...

science.org
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📢 Open Postdoctoral Position! Interested in cellular plasticity and translational control? Don't miss this opportunity! We are looking for a motivated postdoctoral researcher to join our team and contribute to cutting-edge research. 🔗 For more information👇
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BökeLab retweeted
Michael Baym@baymJun 21
“Towards”
Eric Topol
@EricTopolJun 19
AI in medicine is moving rapidly to take on much broader tasks than ever, some not fully envisioned. It's not proven in real medicine yet, but the results of the 2 new @Nature papers this week foreshadow where we may be headed. erictopol.substack.com/p/age…
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BökeLab retweeted
Arjun Raj
@arjunrajlabMay 29
Can someone start a journal called “Cell Atlases” so that the rest of the journals can go back to publishing interesting things?
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It was amazing to participate in #PeopleinRed fundraiser gala, as a guest of the mayor of Barcelona! A lovely reminder that science reaches far beyond the lab -- EB
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