@DiercksLab

Assistant Professor in Chemistry @ScrippsResearch, La Jolla

 San Diego, CA
dierckslab.com
Joined July 2024
  • Tweets11
  • Following396
  • Followers174
Christian Diercks retweeted
Chang Liu
@chang_c_liu16 Aug 2025
Our new company, K2 Therapeutics, is off to the races to develop antibody drugs that target multipass membrane proteins. We are hiring so check us out! k2-tx.com/home#careers
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T7-ORACLE Foretells Functional Proteins by Accelerating Evolution The #syntheticbiology platform accelerates protein evolution thousands of times faster than nature for broad therapy applications @scrippsresearch #proteins #antibodies #enzymes hubs.li/Q03C7zjy0

T7-ORACLE Foretells Functional Proteins by Accelerating Evolution

The synthetic biology platform accelerates protein evolution thousands of times faster than nature for broad therapy applications.

genengnews.com
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Scientists in the lab of Peter Schultz, the President and CEO of Scripps Research, and assistant professor Christian Diercks (@DiercksLab) have developed a synthetic biology platform that accelerates evolution itself—enabling researchers to evolve proteins with useful, new properties thousands of times faster than nature, and bypassing the slow, laborious methods currently used in medicine and biotechnology. The T7-ORACLE orthogonal system targets only plasmid DNA (small, circular pieces of genetic material), leaving the cell’s host genome untouched. It has the potential to help scientists more rapidly evolve antibodies to target specific cancers, evolve more effective therapeutic enzymes, and design proteases that target proteins involved in cancer and neurodegenerative disease. More at: ow.ly/C8AJ50WEKgm
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Christian Diercks retweeted
Chang Liu
@chang_c_liu8 Aug 2025
Happy to see this new T7 replicon based orthogonal replication system in E. coli. Congrats to the Diercks and Schultz lab teams at Scripps Research! science.org/doi/10.1126/scie…

An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli

Systems that perform continuous hypermutation of designated genes without compromising the integrity of the host genome can substantially accelerate the evolution of new or enhanced protein functio...

science.org
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An Orthogonal T7 Replisome for Continuous Hypermutation and Accelerated Evolution in E. coli biorxiv.org/cgi/content/shor… #biorxiv_synbio
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Happy to share the publication of our latest manuscript in Science! With Peter Schultz's lab and my team at Scripps Research we developed T7-ORACLE – an orthogonal replication system for continuous hypermutation and accelerated evolution in E. coli. science.org/doi/10.1126/scie…

An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli

Systems that perform continuous hypermutation of designated genes without compromising the integrity of the host genome can substantially accelerate the evolution of new or enhanced protein functio...

science.org
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Christian Diercks retweeted
Yuzhong Liu@Liulabscripps20 Feb 2025
Super honored and thrilled to receive the Michelson Prize: Next Generation Grant! Thank you #MichelsonPrizes for the support as we work hard toward developing better and safer vaccine adjuvants. I'm grateful for this opportunity, and very excited for the journey ahead!
Michelson Medical Research Foundation
@MichelsonMedRF19 Feb 2025
We’re thrilled to announce the 2024 #MichelsonPrizes recipients alongside @ImmunomePro. Congratulations to Dr. Omar Abudayyeh, Dr. Caleb Lareau, & Dr. Yuzhong Liu! The proposals seek to advance vaccine & immunotherapy design and our understanding of varied immune responses.
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Christian Diercks retweeted
Yanran Li@YL_UCSD17 Jan 2025
Thrilled to share our work using microbial cell factory to investigate strigoractone biosynthesis and evolution. So fortunate to work with such an amazing team of scientists. @nelson_lab @ShabekLab science.org/doi/10.1126/scie…

Evolution of interorganismal strigolactone biosynthesis in seed plants

Strigolactones (SLs) are methylbutenolide molecules derived from β-carotene through an intermediate carlactonoic acid (CLA). Canonical SLs act as signals to microbes and plants, whereas noncanonical...

science.org
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Interested in continuous evolution of biomacromolecules or in the development of Darwinian nanoparticles for gene delivery! Then apply to be a postdoctoral researcher in the Diercks Lab at Scripps. More information at dierckslab.com or at recruiting2.ultipro.com/SCR1…

Diercks Lab | Synthetic Evolution

The Diercks Lab in the Department of Chemistry at Scripps Research leverages an orthogonal replication system in E. coli, termed T7 ORACLE, for the development of protein and enzyme therapeutics and...

dierckslab.com
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Christian Diercks retweeted
Chang Liu
@chang_c_liu1 Sep 2024
In this account, Peter Schultz describes some major themes and projects from his group and career at the interface of chemistry and biology. What legendary science and scientists with much more ahead! I'm grateful to have been among his PhD students. pubs.acs.org/doi/10.1021/acs…

Synthesis at the Interface of Chemistry and Biology

Conspectus. Chemical synthesis as a tool to control the structure and properties of matter is at the heart of chemistryfrom the synthesis of fi

pubs.acs.org
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Prof. Yuzhong Liu is pioneering a sustainable method to produce QS-21, a highly sought-after molecule that improves vaccine effectiveness in yeast. This innovative approach reduces environmental impact and makes vaccines more accessible. Read the full Q+A: ow.ly/Blw150Snzc3
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