@ShabekLab
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Associate Professor & PI @UCDavis ∙structural biologist⚛︎ ubiquitin system aficionado ✾ signaling & sensing mechanisms in plants🌱🎸dad of 2
Davis, CA
Joined June 2018
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🔥our latest study is now online @NatureComms we found that the salicylic acid catabolic enzymes DMR6/DLO1 are controlled by the ubiquitin system. SA modulates their turnover, revealing a regulatory circuit linking hormone metabolism to immune balance. nature.com/articles/s41467-0…
Nitzan Shabek retweeted
In Memoriam: Meng Chen, Professor of Botany and Plant Sciences cnas.ucr.edu/news/2026/09/15…
#UCRscience #botany #plantsciences #ucr #ucriverside
Check out our new review @ThePlantCell
A collaborative effort with Yangnan Gu and Shou-Ling Xu, and members of our labs, bringing together practical lessons for designing, executing, and interpreting proximity-labeling proteomics in plants: academic.oup.com/plcell/arti…
Two decades after revealing the mechanism of action of auxin, we have now uncovered the molecular mystery of another plant hormone: salicylic acid (SA), the precursor of aspirin that most of us have taken at some point in our lives. We were surprised again rdcu.be/EbdVwEStSHha
Nitzan Shabek retweeted
🔥check out our latest. From signalling to catabolism: terminal tails in plant hormone regulation.
Hormone catabolism is no passive cleanup, but a highly regulated process, exemplified by strigolactone & salicylic acid deactivation & structural plasticity.
academic.oup.com/jxb/article…
🔥check out our latest. From signalling to catabolism: terminal tails in plant hormone regulation.
Hormone catabolism is no passive cleanup, but a highly regulated process, exemplified by strigolactone & salicylic acid deactivation & structural plasticity.
academic.oup.com/jxb/article…
Nitzan Shabek retweeted
recruit.ucdavis.edu/JPF07777 The Dept. of Evolution & Ecology at UC Davis will be hiring this Fall! We're searching broadly, from macro (speciation, comparative genomics, evo-devo) to micro (pop biology, adaptive evolution, evo-eco). Please reach out if you have questions, and apply!
check out our latest review.
Beyond prediction: Why experimental structural biology remains essential in plants.
sciencedirect.com/science/ar…
Nitzan Shabek retweeted
Plants Walk a Fine Line Between Growth and Defense @ucdavisbiology ucdavis.edu/news/plants-walk…
DMR6 undergoes SA-dependent conformational remodeling linked to turnover. We mapped the SCF E3 ligase adaptor interactome during infection, revealing dynamic remodeling, & identified ligase DAF1 using TurboID-DMR6/DLO1. Thanks @ShabekLab members, @Zerbe_Lab, Walley & Dinesh-Kumar
Excited to share our latest review on ubiquitin ligases in plant immunity:
onlinelibrary.wiley.com/doi/…
Humbled and honored to receive the UC Davis Distinguished Teaching Award 🏅
Beyond our research mission, education & mentoring are at the core of what we do @ucdavis & I’m grateful for the opportunity to teach such engaged & motivated students ucdavis.edu/news/senate-and-…
Excited to share our new review, now online @AnnualReviews : Structural Insights into Plant Hormone-Sensing Mechanisms
annualreviews.org/content/jo…
Nitzan Shabek retweeted
Please RT‼️@meo0205 & us are looking for a #postdoc to explore #regeneration & #autophagy across kingdoms of life.Please spread the word & get in touch if interested. health-life-sciences.de/oppo…
Excited to share our lab's latest discovery today in @Nature: "orthosteric molecular glue” (OMG) inhibitors - a new drug design strategy that achieves substrate-dependent potency, i.e., substrate selectivity, with conventional orthosteric inhibitors. rdcu.be/e3waV
Excited to share our latest work to close out 2025: Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation🌱 With the Walley lab, we map how ASK1/SKP1 dynamically rewires protein networks during stress. biorxiv.org/content/10.64898…
Proximity labeling and quantitative proteomics suggest that ASK1/SKP1 assembles condition-specific networks, acting both within SCF E3 #ubiquitin ligases and through noncanonical interactions to coordinate #plant stress adaptation
Nitzan Shabek retweeted
Please RT‼️ #TenureTrack position @ZmbhH - one of the best #proteostasis research centres in the world. nature.com/naturecareers/job…
