Molecular medicine PhD student @ClevelandClinic/@CWRUSOM. @CaseEngineer alumn.
Cleveland, OH
Joined June 2017
- Tweets87
- Following475
- Followers155
- Likes2.4K
Dean Pontius retweeted
We are excited to announce we have achieved the first-ever therapeutic #RNAediting in humans in our RestorAATion-2 trial of WVE-006 in Alpha-1 antitrypsin deficiency. Learn more. #AATD $WVE
Dean Pontius retweeted
A recent commentary in bioRxiv discussed data analysis for our mtDNA-based lineage tracing technology ReDeeM. We welcome the points raised and are happy to address these concerns. We believe this will foster constructive dialogue (1/n) doi.org/10.1101/2024.08.23.6…
Dean Pontius retweeted
Want to support student lead research in CLE?
Students in the 'Life as a Scientist' program are finishing their grant proposals! Once awarded, we supply all of the equipment, materials, and professional support they need to complete their project.
riseupnortheastohio.org/dona…
Dean Pontius retweeted
Excited to share a favorite project, now out on @biorxivpreprint . biorxiv.org/content/10.1101/… This has been a big undertaking for the past couple years: two (!) year-long rounds of retinal organoid differentiation by Laura Bohrer... (1/8)
Dean Pontius retweeted
📢 Preprint alert! 🚨 Superstar postdoc, @marissascavuzzo, leads our latest work titled "Enteric glial hub cells coordinate intestinal motility".
Marissa is a @HHMInews Hanna Gray Fellow and a former @NYSCF Druckenmiller Fellow.
🙌Read the study here 👇
biorxiv.org/content/10.1101/…
Great to see this out - awesome work by twitterless lab mate Devin Neu!
Oncogenic reactivation of young L1s is a hallmark of colon cancer biorxiv.org/cgi/content/shor… #bioRxiv
Dean Pontius retweeted
Glad to share our new paper describing gene expression changes in single RPE cells between regions of the retina. I hope this can be a useful dataset for others studying macular disease! Data are also available for your perusal on singlecell-eye.org!
pubmed.ncbi.nlm.nih.gov/3677…
ALT Experimental schematic showing isolation of RPE nuclei for single-nucelus multimodal sequencing.
Dean Pontius retweeted
Really excited to share my first first-author @biorxivpreprint from my thesis work from @TesarLab. Thanks to everyone involved!
Excited to share a new @biorxivpreprint "Pervasive environmental chemicals impair oligodendrocyte development" led by a superb MD/PhD @CWRUmstp student, Erin Cohn @ErinFCohn. We appreciate all feedback on this surprising (and sorta scary 😱) study.
biorxiv.org/content/10.1101/…
Dean Pontius retweeted
Our preprint on PTEN mutant organoids is also out biorxiv.org/content/10.1101/…
Also, watch out for more data on PTEN mutant organoids by @ShuaiFu2 and Anthony Wynshaw-Boris, their great work should be up on bioRxiv soon!
Dean Pontius retweeted
🔌⚡️🏘️
Excited to share our new @biorxivpreprint: "Non-random distribution of mitochondrial m.3243A>G heteroplasmy in human retina and its impact on cellular phenotype."
biorxiv.org/content/10.1101/…
Question: how does mtDNA distribution inform mitochondrial disease phenotype? 🧵👇
Dean Pontius retweeted
Very excited to be elected as a Senior Member of the National Academy of Inventors @AcadofInventors. I hope that past, present, and future innovations from the @TesarLab will make a difference for patients and their families.
It is our distinct pleasure to announce the election of the Class of 2022 #NAISeniorMembers!
We congratulate this Senior Member class, well on their path of prolific discovery, and welcome them into the NAI Community. See the full Class of 2022: ow.ly/ieZa50HR5W2
Dean Pontius retweeted
Happy to share our recent foray into mitochondrial genetics out in @hmg_journal! Here we used digital PCR to relate peripheral m.3243A>G heteroplasmy to the presentation of visual symptoms. I am excited to keep learning more about this fascinating field!
academic.oup.com/hmg/advance…
Dean Pontius retweeted
Please share/retweet: @QBI_UCSF is hosting an event for Native/Indigenous biomedical scientists lead by @willowcoyote. We are looking for undergrad, grad student, and postdoc Native speakers! Deadline is September 1st to apply for a talk!
qbi.ucsf.edu/Native-Indigeno…
Dean Pontius retweeted
Our studies are expanding from cancer into other major public health crises. Check out our latest on opioid use disorder. Team effort with Akbarian, Johnson, Mash, and @CorradinLab. biorxiv.org/content/10.1101/…
Dean Pontius retweeted
Delighted to share our work studying the molecular control for the directed β cell differentiation process @NatMetabolism
nature.com/articles/s42255-0…
Great collaboration with Jiajia Xi @FulaiJin lab and Yan Li lab @CWRUSOM.
Dean Pontius retweeted
New paper from our team out today in @CellStemCell. In this work we show the mechanism by which low oxygen damages myelinating cells in the brain and reframe therapeutic strategies for combatting hypoxia-mediated disease.
cell.com/cell-stem-cell/full…
A thread…
Dean Pontius retweeted
It is so sad that this the way the U.S. treats international students. We have to fight this - to make these student uproot their lives or risk their health during a pandemic is beyond horrible. Sign this petition! chng.it/TYD5Xtw8ZP
Dean Pontius retweeted
New paper from our team out today in @nature. We show a new treatment approach for neurological diseases of myelin and demonstrate therapeutic efficacy to rescue and fully extend lifespan in mice with a fatal myelin disease.
nature.com/articles/s41586-0…
A thread on the journey…
Dean Pontius retweeted
Our work is online today. A collaboration with the labs of Yan Li, Guo-li Ming, Hongjun Song, Patrick Sullivan, et al. We demonstrated that robust Hi-C mapping of sub-TAD E-P interactions requires more rigorous bias-correction (with HiCorr).
cell.com/molecular-cell/full…
