@DadarMahsa

Assistant Professor at the Douglas Cerebral Imaging Centre (CIC) @DouglasResearch @mcgillu

 Montréal, Québec
vandalab.github.io/
Joined June 2015
  • Tweets642
  • Following633
  • Followers574
11Media
We are excited to launch The Data Quartet Challenge, recognizing student contributions to projects that integrate data from at least 2 of 4 FRQ supported Quebec Alzheimer’s and Aging cohorts (PREVENT-AD, CIMA-Q, NuAge, TRIAD), with 3 prizes of 5000$ tinyurl.com/3dy899xn
1
5
1
9
723
🚨 New preprint 11,000+ human brain microvessels in cSVD • Early bimodal pericyte loss • Later endothelial activation w/ a venous-like inflammatory shift • ↑ capillary density with disease 💡 Suggests sequential vascular pathology, not parallel 🔗 shorturl.at/KZapP
2
8
1
31
2,905
Mahsa Dadar retweeted
Stephen Smith@fmrib_steveOct 9
Imaging Neuroscience: The First 3 Years—Editorial Thanks to our Editorial Board, reviewers, and authors, who trusted that this would work, and moved with us to the new journal. Its success belongs to that community. doi.org/10.1162/IMAG.a.1392

Imaging Neuroscience: The First Three Years—Editorial

Abstract. In April 2023, the editors of NeuroImage and NeuroImage:Reports resigned, and a month later launched Imaging Neuroscience. NeuroImage had been the leading journal in our field, but its...

direct.mit.edu
1
14
39
2,761
More data to enable more discoveries in the fight against Parkinson's disease. 👇 nature.com/articles/s41597-0…
8
24
1,180
🚨In this detailed analysis of imaging features of small vessel disease (CSVD) in the national COMPASS-ND cohort, we show how CSVD burden contributes to poorer cognition across neurodegenerative conditions and cognitive profiles alz-journals.onlinelibrary.w… @alzdemjournals @ccna_ccnv
Violin-box and stacked bar plots of cognitive outcomes as a function of CSVD scores showing worsening outcomes with higher CSVD burden. Raw unadjusted data are shown. Corresponding p values are shown in top right of plot and were extracted from linear or median quantile regression, as appropriate, adjusted for age, sex, and years of education. Better cognitive function is indicated by higher MoCA scores, lower CDR-SB scores, and higher neuropsychological composite z-scores. MoCA, Montreal Cognitive Assessment; CDR-SB, Clinical Dementia Rating-Sum of Boxes; CSVD, cerebral small vessel disease.

ALT Violin-box and stacked bar plots of cognitive outcomes as a function of CSVD scores showing worsening outcomes with higher CSVD burden. Raw unadjusted data are shown. Corresponding p values are shown in top right of plot and were extracted from linear or median quantile regression, as appropriate, adjusted for age, sex, and years of education. Better cognitive function is indicated by higher MoCA scores, lower CDR-SB scores, and higher neuropsychological composite z-scores. MoCA, Montreal Cognitive Assessment; CDR-SB, Clinical Dementia Rating-Sum of Boxes; CSVD, cerebral small vessel disease.

2
10
23
1,667
1⃣On average, FA reached maturity at the youngest age (mean=29.2 years), followed in order by RD (mean=35.8 years), MD (mean=41.7 years) and AD (mean=48.2 years). We found evidence supporting the ‘last-in, first-out’ hypothesis, for FA, MD and AD.
1
6
14
1,348
Mahsa Dadar retweeted
Olivier Parent@oparent41May 26
New paper “Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions” out in Nature Communications! doi.org/10.1038/s41467-026-7…

Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle...

Nature Communications - Using advanced MRI modeling, this study found distinct spatial and pathophysiological signatures in vascular- and neurodegeneration-related white matter hyperintensities,...

nature.com
1
7
18
1,402
Mahsa Dadar retweeted
Olivier Parent@oparent41May 26
I'm proud to share this work led from the @DouglasResearch and the @IPNMcGill and funded by the @AlzCanada and the @FRQS1. Special thanks to my supervisors, @mallarchkrvrty1 and @DadarMahsa, who showed great patience every time I added an analysis to this project in the last 4y!
1
1
2
128
Cerebral amyloid angiopathy (CAA) is frequently seen in individuals aged 50 years+ presenting with a cognitive complaint, and patients with probable CAA according to the Boston criteria V1.5 but not V2.0 have increased risk of dementia: hubs.la/Q04hKdpp0
9
1
27
5,255
Inflammaging: From Mechanisms to Clinical Implications and Targeted Interventions "...opportunities and limitations of these approaches for identifying individuals at risk for chronic disease..." aginganddisease.org/EN/10.14…
12
23
1,741
Up to age 60, adult brain volume completely dominated by stable individual diffs. At 80 yrs, up to 50% reflects differences in change. Interpretation: 1) We change similarly up to 60. 2) Group comparisons often not reflecting changes. @Edvardosg @LCBC_UiO direct.mit.edu/imag/article/…

Stable individual differences dominate adult brain volume variation until later life

Abstract. Individual differences in the volumes of brain structures are often linked to various conditions, including Alzheimer’s disease, schizophrenia, and overall brain health. However, it remains...

direct.mit.edu
2
9
24
2,353
Excited to share our latest HBM paper on Recon-any: a free tool for robust cortical surface analysis of low-field MRI of any contrast/resolution (also ex vivo!). Toward accessible neuroimaging! onlinelibrary.wiley.com/doi/… Freely available on @FreeSurferMRI : surfer.nmr.mgh.harvard.edu/f…

From Low Field to High Value: Robust Cortical Mapping From Low‐Field MRI

Recon-any processes a brain MRI acquired with arbitrary contrast, resolution, and field strength to generate morphometric measurements comparable to FreeSurfer's recon-all, including cortical...

onlinelibrary.wiley.com
2
22
1
57
3,046
Mahsa Dadar retweeted
Brian Edlow@ComaRecoveryLabApr 18
Two new tools to map the human brainstem: nuclei: onlinelibrary.wiley.com/doi/… bundles: pnas.org/doi/10.1073/pnas.25… code: surfer.nmr.mgh.harvard.edu/f… github.com/markolchanyi/BSBT @olchanyi @JuanEugenioIgl1 @MGHMartinos @MGH_CNTR @MGBResearchNews @MIT
2
54
1
210
13,309
Please RX - 🚨We’re hiring @CRCHUM @UMontreal — Professor, Emerging Viral Threats. DM for more info.
4
5
834
Mahsa Dadar retweeted
Bratislav Misic@misicbataMar 11
Synaptome architecture shapes regional dynamics in the mouse brain | doi.org/10.1371/journal.pbio… How do diverse synapses relate to the spatial patterning of whole-brain dynamics? @JustineYHansen explores @PLOSBiology ⤵️
3
23
2
67
10,569
The NeuroBioBank whole-genome catalogue of human brain donors with central nervous system disorders | Brain academic.oup.com/brain/advan…

The NeuroBioBank whole-genome catalogue of human brain donors with central nervous system disorders

Hupalo et al. have released whole-genome sequences from 9543 human brain donors paired with neurological and psychiatric disease diagnoses. Created in coll

academic.oup.com
4
16
1,133
The first time you start a research lab, there’s no manual. So I made one. A practical toolkit for postdocs and early-career faculty launching their first lab: hiring, startup planning, collaborations, and building a sustainable research program. zenodo.org/records/18883545

Launching Your First Research Lab: Practical Guidance on Planning Your Research Program, Building a...

Starting an independent research lab is one of the most significant transitions in an academic career, yet many scientists receive little formal training in the practical aspects of launching and...

zenodo.org
23
337
8
1,991
132,440
Mahsa Dadar retweeted
JAMA Neurology@JAMANeuroMar 1
Greater adherence to the #DASH diet, plant-based dietary patterns, or diets with lower hyperinsulinemia and inflammation was associated with lower risk of subjective cognitive decline and better cognitive function in adults. ja.ma/3MNfcSH
Figure 1. Forest Plots showing associations of dietary pattern scores with cognitive decline. Graphs compare AHEI-2010, DASH score, hPDI, PHDI, rEDIP, rEDIH across global SCD, memory, executive function, attention and orientation. Includes RR(95% CI) values.

ALT Figure 1. Forest Plots showing associations of dietary pattern scores with cognitive decline. Graphs compare AHEI-2010, DASH score, hPDI, PHDI, rEDIP, rEDIH across global SCD, memory, executive function, attention and orientation. Includes RR(95% CI) values.

14
1
37
3,716
Sex Differences in Amyloid Pathology by Race, Ancestry, and APOE ε 4 jamanetwork.com/journals/jam…

Sex Differences in Amyloid Pathology by Race, Ancestry, and APOEε4

This cross-sectional study evaluates associations of neuritic plaque burden and cognitive outcomes with sex, apolipoprotein E ε4 status, race, and ancestry.

jamanetwork.com
1
7
24
2,054
Potentially modifiable risk factors for dementia in Norway (HUNT4 70+): a retrospective cohort study 👉"Addressing all 14 Lancet risk factors could prevent over half of all dementia cases." thelancet.com/journals/lanhl…
1
6
1
33
3,428
New hi-res subcortical atlas defined at 100 microns! Manually delineated using MRI, fibre tracking and histology biorxiv.org/content/10.64898… datadryad.org/dataset/doi:10… @andreashorn_ Helen Friedrich & team
1
20
2
70
4,305
Load more