@DTaylorLab

Research lab at Case Western Reserve University using structural biology, molecular mechanism, and cellular outcome to understand and treat cancer.

 Cleveland, OH
TheTaylorLab.com
Joined June 2020
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🌟 Exciting News! Eric has been named #PostdocOfTheMonth! 🎉 Check out the full interview on the university's daily news site! thedaily.case.edu/postdoc-of… #ScienceSpotlight [Link to interview] 📚🔬
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Replying to @ballenpetersen @cwru
Thrilled to have had the chance to host you and to hear all about the exciting #BAPlab projects! Your insights on #PP2A and its role in pharmacology were truly enlightening. Looking forward to more such exchanges in the future! #ScienceCommunity #Collaboration
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Our preprint is out! We hacked the @nanopore sequencer to read amino acids and PTMs along protein strands. This opens up the possibility for barcode sequencing at the protein level for highly multiplexed assays, PTM monitoring, and protein identification! biorxiv.org/content/10.1101/…

Multi-pass, single-molecule nanopore reading of long protein strands with single-amino acid...

The ability to sequence single protein molecules in their native, full-length form would enable a more comprehensive understanding of proteomic diversity. Current technologies, however, are limited...

biorxiv.org
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Today in partnership with @IsomorphicLabs, we're sharing progress on the next generation of #AlphaFold. 🧬 Our new model greatly expands coverage of structure prediction beyond proteins to other key biomolecular classes. How could it help scientists? 🧵 dpmd.ai/alphafold-progress
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🦠🧬 Dive into the fascinating world of how bacteriophage T4 ingeniously hijacks E. coli's cellular machinery! Unveil the intriguing process of ‘RNAylation’! RNAylation-installing RNA strands onto the arginine residues of target proteins. #RNAylation 👇 nature.com/articles/s41586-0…

A viral ADP-ribosyltransferase attaches RNA chains to host proteins

Nature - Bacteriophage T4 uses an enzyme known as ADP-ribosyltransferase ModB to modify the translational apparatus of bacteria it infects, not only by ADP-ribosylating proteins, but also by...

nature.com
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🎉 Kudos to @vignesh_k757 and Cech team for revealing a stunning structure & applying streptavidin grids innovatively! Shedding light on the fascinating functional role of G4 RNA, pushing the boundaries of our understanding. Fantastic achievement! science.org/doi/10.1126/scie…

Structural basis for inactivation of PRC2 by G-quadruplex RNA

Cryo–electron microscopy structure of RNA-bound PRC2 dimer elucidates an unexpected mechanism of PRC2 inhibition by RNA.

science.org
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🎉 Huge congrats to Brendan Sheehan for securing a training grant from the National Institute of General Medical Sciences! 🎓 So proud of this remarkable achievement. Onward and upward! 🌟 #NIGMS #T32 #FutureOfScience #GrantAchievement 🙌🔬
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So proud of our research team and our collaborators; our paper just came out in Nature Communications today So proud of our research team and our collaborators; our paper just came out in Nature Communications today - nature.com/articles/s41467-0…

Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progres...

Nature Communications - Loss of PP2A activity is often associated with cancer but the underlying mechanism remains unclear. Here, the authors show that decreased methylation of PP2A catalytic C...

nature.com
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TheTaylorLab retweeted
Gopal Sapkota@gpsapkota20 Sep 2023
PP2A holoenzyme is thought to dephosphorylate hundreds of substrates. By degrading its catalytic subunit followed by an unbiased phosphoproteomic analysis, we find out just how many! Find out if your proteins are PP2A substrates...biorxiv.org/cgi/content/shor… @kesslet345 @mrcppu
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Ever wonder about the hidden costs of drug toxicity? The latest research sheds light on an often overlooked area: the impact of off-target drug interactions on intracellular RNAs. 🧬 #DrugSafety #Transcriptomics #Pharmacology #Toxicity #Innovation nature.com/articles/s41557-0…

Pervasive transcriptome interactions of protein-targeted drugs

Nature Chemistry - Now a reactivity-based RNA profiling strategy can measure the global off-target transcriptome interactions of small-molecule drugs at single-nucleotide resolution. Using this...

nature.com
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Very nice to read, the needs of map the interactions of small-molecule drugs with RNA in cells 🤔🤔🤔 nature.com/articles/s41557-0….
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🎉 Exciting News! 🎉 A huge congratulations to #twitterless Eric Mosher for securing a Cancer Biology Training Grant from the prestigious @caseccc and @theNCI! Here's to groundbreaking research ahead! 🧪🔬 #CancerResearch #TrainingGrant #TeamExcellence
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In honor of @joachimfrank's birthday, the #cryoEM community has convened today to celebrate his contributions to science! We're excited to see this lineup of speakers incl. @yifan_ucsf, @TheVillaLab, @NogalesLab, @bcarra2, @JM_Carazo, @Hashemyaser4 & more: ter.li/p57iit
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Dear #Ribosome and #CryoEM aficionados, join us for a unique opportunity to attend a symposium organized in honor of the 80+ birthday of Joachim Frank @joachimfrank, an outrageously prestigious line-up of speakers, in NYC, this summer, just before the CSH trans. cont. Meeting!!!!
Ruben Gonzalez@rubenlgonzalez20 May 2022
Hey, cryo-EM and ribosome/translation Twitter, we're very happy to announce (please RT): A Symposium in Honor of the 80+ Birthday of Joachim Frank. Details and registration info can be found at joachimfrank.wixsite.com/jf8…
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Peter Shen@shen_utah3 May 2022
In collaboration with @janetiwasa and Julia Brasch (@zauberhoernchen), we are thrilled to announce that the first chapter of CryoET 101 is officially released! Curious about cryo-ET and if it's the right method for your project? Check it out at cryoem101.org/chapter-1-et/.
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Replying to @MbtpPurdue @PurdueSCBB @KScrudders @leifuchang @lchangpurduebio
I thoroughly enjoyed meeting the trainers and trainees in the Frontiers in Biophysics Program at Purdue (@MbtpPurdue @PurdueSCBB) yesterday. Such an impressive program. Thanks for hosting me!
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This is great news!
NIBR (@NovartisScience) NLRP3 inflammasome inhibitor functions as an intramolecular glue – locking the protein in an inactive conformation sciencedirect.com/science/ar…!
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Replying to @SchlessingerLab @CWRUSOM @Chakrapani_lab
Thanks, Avner! It was great having you here and in-person!
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We are big fans of Cathy Hannes @HelloCancerFri1. Cathy is a cancer survivor, blogger, and one of the most positive people we've met. She is a true inspiration!
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