Scientists at Mount Sinai have uncovered the first high-resolution structure of NBCn2, a brain protein linked to epilepsy, autism spectrum disorder, and other neurological conditions, and developed the first compounds capable of inhibiting its activity. Published in @NatureComms, the study used cryo-electron microscopy to capture the first highly detailed structural images of NBCn2, revealing how it transports sodium and carbonate ions that help regulate cellular acidity and control brain cell activity. The researchers also found that the way NBCn2 binds these ions differs from related proteins, suggesting that even closely related transporters may operate in distinct ways. The findings could help researchers better study disorders involving excessive neuronal activity and provide a new framework for understanding how altered brain signaling contributes to disease — potentially advancing future therapeutic research. Learn more about the research: mshs.co/4pRRvYy @MSHSNeurology @SinaiBrain @SinaiGenetics @SchlessingerLab #Neuroscience #Research #BrainResearch #Epilepsy