Research lab at Case Western Reserve University using structural biology, molecular mechanism, and cellular outcome to understand and treat cancer.
Cleveland, OH
Joined June 2020
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TheTaylorLab retweeted
Our preprint is out! We hacked the @nanopore sequencer to read amino acids and PTMs along protein strands. This opens up the possibility for barcode sequencing at the protein level for highly multiplexed assays, PTM monitoring, and protein identification!
biorxiv.org/content/10.1101/…
TheTaylorLab retweeted
Today in partnership with @IsomorphicLabs, we're sharing progress on the next generation of #AlphaFold. 🧬
Our new model greatly expands coverage of structure prediction beyond proteins to other key biomolecular classes.
How could it help scientists? 🧵 dpmd.ai/alphafold-progress
TheTaylorLab retweeted
So proud of our research team and our collaborators; our paper just came out in Nature Communications today
So proud of our research team and our collaborators; our paper just came out in Nature Communications today - nature.com/articles/s41467-0…
TheTaylorLab retweeted
PP2A holoenzyme is thought to dephosphorylate hundreds of substrates. By degrading its catalytic subunit followed by an unbiased phosphoproteomic analysis, we find out just how many! Find out if your proteins are PP2A substrates...biorxiv.org/cgi/content/shor… @kesslet345 @mrcppu
TheTaylorLab retweeted
Very nice to read, the needs of map the interactions of small-molecule drugs with RNA in cells 🤔🤔🤔
nature.com/articles/s41557-0….
TheTaylorLab retweeted
In honor of @joachimfrank's birthday, the #cryoEM community has convened today to celebrate his contributions to science! We're excited to see this lineup of speakers incl. @yifan_ucsf, @TheVillaLab, @NogalesLab, @bcarra2, @JM_Carazo, @Hashemyaser4 & more: ter.li/p57iit
TheTaylorLab retweeted
Dear #Ribosome and #CryoEM aficionados, join us for a unique opportunity to attend a symposium organized in honor of the 80+ birthday of Joachim Frank @joachimfrank, an outrageously prestigious line-up of speakers, in NYC, this summer, just before the CSH trans. cont. Meeting!!!!
Hey, cryo-EM and ribosome/translation Twitter, we're very happy to announce (please RT):
A Symposium in Honor of the 80+ Birthday of Joachim Frank. Details and registration info can be found at joachimfrank.wixsite.com/jf8…
TheTaylorLab retweeted
🤩
In collaboration with @janetiwasa and Julia Brasch (@zauberhoernchen), we are thrilled to announce that the first chapter of CryoET 101 is officially released! Curious about cryo-ET and if it's the right method for your project? Check it out at cryoem101.org/chapter-1-et/.
TheTaylorLab retweeted
NIBR (@NovartisScience) NLRP3 inflammasome inhibitor functions as an intramolecular glue – locking the protein in an inactive conformation sciencedirect.com/science/ar…!
TheTaylorLab retweeted
It’s official! Bryan Webb is now Dr. Bryan Webb! Great work in CDK7 in #breastcancer and now on to finishing #medschool. Please help me congratulate him! @CCLRI @cwru @cwrumstp @caseccc @CWRUSOM @StanGersonMD
TheTaylorLab retweeted
STRIPAK is a huge multi-subunit phosphatase complex that serves as a hub for Hippo signaling. A #cryoEM structure from the Luo lab @sueluo67 @UTSWNews reveals its distinct architecture:
nature.com/articles/s41594-0…
TheTaylorLab retweeted
Now with News & Views from @DTaylorLab @xjtuhw @cwru :
Pack a STRIPAK with hubs inside a hub
nature.com/articles/s41594-0…
TheTaylorLab retweeted
Incredibly proud of our work published today in @JCI_insight (a culmination of five years of work). Congratulations to @JulianneNPSmith for steering the ship, and to our collaborators @caseccc for keeping us afloat!
insight.jci.org/articles/vie…