@DGateLab

Director, Abrams Research Center, Northwestern Neurology. The Gate lab studies the immune system in neurodegenerative diseases.

 Chicago, IL
sites.northwestern.edu/gatelab/
Joined September 2019
  • Tweets352
  • Following2K
  • Followers3.3K
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New paper from the Colonna lab! cMAF is a key regulator of BAM identity and drives communication with brain arteries via IGF1. We show that this cMAF-dependent program in BAMs supports cerebrovascular function in mice and is protective against AD. cell.com/cell/fulltext/S0092…

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcript...

This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in...

cell.com
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Really amazing collaboration with such an excellent team of researchers. My lab was fortunate to play a part in this fantastic work.
Julia Belk
@juliabelkAug 14
The transcription factor MAF is known from human genetics to be important in Alzheimer’s disease, but its precise function within the brain has been unclear. Our latest, out today in @CellCellPress, dissects the role of MAF in brain macrophages. 1/ cell.com/cell/fulltext/S0092…

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcript...

This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in...

cell.com
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Replying to @nottalexi @sj_marzi @HolstegeHenne
What a great team! Congrats!
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Excited to share our latest work on ALS neuroimmunology, published today in @NatureNeuro rdcu.be/fiFM0
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Genetically altered astrocytes that express chimeric antigen receptors offer a promising immunotherapy system capable of clearing accumulations of amyloid-β in the brains of mice—a hallmark pathological feature of #AlzheimersDisease, according to a new study in Science. 📄: scim.ag/3NjPIfP #SciencePerspective: scim.ag/4rgI1oL
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Congrats @DGateLab on having one of the Top 3 Episodes of Breakthroughs Podcast in 2025! If you haven't listened you can do so and learn more here; news.feinberg.northwestern.e…

Top 3 Episodes of Breakthroughs Podcast in 2025 - News Center

This year, the Breakthroughs podcast released 17 episodes on topics including improvements in mental healthcare delivery, precision medicine therapies for rare diseases, an introduction to bedside...

news.feinberg.northwestern.edu
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Key to research success: ambition in vision, but pragmatism in execution. You must be guided by a long-term, ambitious goal that addresses a fundamental problem, rather than chasing incremental gains on established benchmarks. Yet, your progress should be grounded by tractable short-term metrics/tasks that force you to constantly make contact with reality.
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David Gate retweeted
Tempus
@TempusAI12 Jun 2025
We are proud to announce a collaboration with @ARC_Neuro at Northwestern University Feinberg School of Medicine to harness AI for rapid discovery and innovation in Alzheimer’s disease research. Using Lens, the Center and Tempus teams will work together to uncover genomic patterns that have the potential to advance the understanding of Alzheimer’s disease, investigate the gene and cell types affected, enable the development of new therapeutics, and accelerate the creation of novel clinical applications. Learn more: tempus.co/43EIlVJ
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David Gate retweeted
Hamilton Oh@hammy_oh31 Mar 2025
I am excited to present our new study out in @NatureMedicine where we discover a novel synaptic protein biomarker to predict if and when someone will get Alzheimer’s disease dementia. Part 2/3 from my PhD work in the @wysscoray lab. 🧵1/12 Full study 🔗: nature.com/articles/s41591-0…

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus...

Nature Medicine - The ratio between the levels of two synaptic proteins in cerebrospinal fluid predicts future cognitive resilience versus decline among presymptomatic individuals and individuals...

nature.com
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The Gate lab is fortunate to have such a talented scientist like @TerryRSuk joining us soon. Check out his impressive work!
Terry R Suk@TerryRSuk28 Mar 2025
We’re happy to share that our labs first #ALS and #FTD study “A stress-dependent TDP-43 SUMOylation program preserves neuronal function” is now online @MolNeuro! doi.org/10.1186/s13024-025-0…

A stress-dependent TDP-43 SUMOylation program preserves neuronal function

Molecular Neurodegeneration - Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are overwhelmingly linked to TDP-43 dysfunction. Mutations in TDP-43 are rare, indicating that...

link.springer.com
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It’s quite an experience to have some of your favorite labs like ⁦@TheColonnaLab⁩ and ⁦@Haass_Lab⁩ comment on your lab’s research. Great reporting by Alzforum! alzforum.org/news/research-n…
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This Northwestern Breakthroughs podcast nicely encapsulates our study. The host does a great job leading the discussion for the lay audience to digest our work. I hope this allows people to better understand the results and impact of this study. youtu.be/bZrdwGQ_Ok0
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Replying to @JustinPerryPhD @jonykipnis @ARC_Neuro
You both make good points! I really appreciate the input.
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Replying to @jonykipnis @WashU @washumedicine
Congrats! What a team!
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Replying to @TheIbrahimLab @ARC_Neuro @LynnOlst
Thank you, my friend!
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This video describes the findings from our recent study conducted at ⁦@ARC_Neuro⁩. In the video, lead author ⁦@LynnOlst⁩ and I discuss the findings and their implications for Alzheimer’s disease. youtu.be/pnRzktJRWAo

Treatment for Alzheimer’s may lie in the brain’s own cleanup crew

For more than three decades, scientists have been racing to stop Al...

youtube.com
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rdcu.be/ecqZW
David Gate@DGateLab6 Mar 2025
Big day today!
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アルツハイマー病の治療は脳自身のクリーンアップクルーにあるかもしれません nipponese.news/%e3%82%a2%e3%…
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Excited to share our latest @NatureMedicine study from our new center @ARC_Neuro! 🧠✨ Using spatial transcriptomics & scRNA-seq, we uncover how Aβ-targeting immunotherapies shape microglial responses in AD patient brains. A thread with our key findings is below! 🧵(1/15)
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Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passive and actively immunized #Alzheimer’s disease patients @NUFeinbergMed nature.com/articles/s41591-0…

Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease

Nature Medicine - Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passively and actively immunized patients with Alzheimer’s disease.

nature.com
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