Director, Abrams Research Center, Northwestern Neurology. The Gate lab studies the immune system in neurodegenerative diseases.
Chicago, IL
Joined September 2019
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- Following2K
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David Gate retweeted
New paper from the Colonna lab! cMAF is a key regulator of BAM identity and drives communication with brain arteries via IGF1. We show that this cMAF-dependent program in BAMs supports cerebrovascular function in mice and is protective against AD.
cell.com/cell/fulltext/S0092…
David Gate retweeted
Genetically altered astrocytes that express chimeric antigen receptors offer a promising immunotherapy system capable of clearing accumulations of amyloid-β in the brains of mice—a hallmark pathological feature of #AlzheimersDisease, according to a new study in Science.
📄: scim.ag/3NjPIfP
#SciencePerspective: scim.ag/4rgI1oL
David Gate retweeted
Congrats @DGateLab on having one of the Top 3 Episodes of Breakthroughs Podcast in 2025! If you haven't listened you can do so and learn more here; news.feinberg.northwestern.e…
David Gate retweeted
Key to research success: ambition in vision, but pragmatism in execution. You must be guided by a long-term, ambitious goal that addresses a fundamental problem, rather than chasing incremental gains on established benchmarks. Yet, your progress should be grounded by tractable short-term metrics/tasks that force you to constantly make contact with reality.
David Gate retweeted
We are proud to announce a collaboration with @ARC_Neuro at Northwestern University Feinberg School of Medicine to harness AI for rapid discovery and innovation in Alzheimer’s disease research. Using Lens, the Center and Tempus teams will work together to uncover genomic patterns that have the potential to advance the understanding of Alzheimer’s disease, investigate the gene and cell types affected, enable the development of new therapeutics, and accelerate the creation of novel clinical applications.
Learn more: tempus.co/43EIlVJ
David Gate retweeted
I am excited to present our new study out in @NatureMedicine where we discover a novel synaptic protein biomarker to predict if and when someone will get Alzheimer’s disease dementia. Part 2/3 from my PhD work in the @wysscoray lab. 🧵1/12
Full study 🔗: nature.com/articles/s41591-0…
David Gate retweeted
In brains of people immunized against Aβ, postmortem omics reveal microglial plaque clearing pathways. @NorthwesternU ow.ly/3cOl50VitbY
David Gate retweeted
アルツハイマー病の治療は脳自身のクリーンアップクルーにあるかもしれません nipponese.news/%e3%82%a2%e3%…
David Gate retweeted
Excited to share our latest @NatureMedicine study from our new center @ARC_Neuro! 🧠✨ Using spatial transcriptomics & scRNA-seq, we uncover how Aβ-targeting immunotherapies shape microglial responses in AD patient brains.
A thread with our key findings is below! 🧵(1/15)
David Gate retweeted
Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passive and actively immunized #Alzheimer’s disease patients @NUFeinbergMed
nature.com/articles/s41591-0…
David Gate retweeted
Excited to announce that we are recruiting at our new Neurogenomics Center at Northwestern! We are looking for passionate postdoc candidates to join our team. nature.com/naturecareers/job…
David Gate retweeted
The team at Abrams Research Center on Neurogenomics, led by @DGateLab, is excited to explore their new lab! Using #ArtificialIntelligence, genetic research and global collaborations, they’re advancing Alzheimer’s disease research. #NMBetter
ALT Two women holding sample strips with red markings.
ALT Scientists in lab coats smiling in a lab.
ALT A scientist in a lab coat holding a pipette.
ALT A scientist in a lab coat holding a pipette.
David Gate retweeted
Our December issue, featuring a Focus on Single Cell Genomics, is now live!
nature.com/neuro/volumes/27/…
David Gate retweeted
David Gate @DGateLab @NUFeinbergMed discusses #proteogenomic approaches to study #neurodegenerative disease #ISMND2024
David Gate retweeted
As my lab develops Seurat, I wanted to share some thoughts on the important Seurat and scanpy package selection preprint from @Josephmrich/@lpachter 🧵
David Gate retweeted
Is the immune system involved in the breakdown of the connection between the brain and muscles in #ALS? @DGateLab is leading research at the Les Turner ALS Center at Northwestern Medicine into the possibility – and how it could inform better care. buff.ly/43LnQ87
David Gate retweeted
Excited to share our group's first manuscript describing new anatomical connections that allow the eyes to act as an "immunological window to the brain" 👁️🧠 (1/)
nature.com/articles/s41586-0…
David Gate retweeted
In people with AD, peripheral immune cells relax their chromatin, unleashing inflammatory genes. @NorthwesternU ow.ly/GfLM50QElnp
David Gate retweeted
A new #Alzheimers Disease (AD) study reveals increased accessible chromatin in patients' peripheral #immunecells. This work illuminates the relationship between #epigenetics and genetic risk factors in AD. @DGateLab @NMNeurology @NorthwesternMed
ow.ly/A8kF50QB82w
David Gate retweeted
Don't let the Early Bird discount fly away!🐦✨ Join us at the #PBIC23 conference and discover new insights on #Gutbrainaxis and #homeostasis. Register before the deadline on 3 October: vibbio.tech/3PVCJiV
