Excited to share work by Emily Wang & Zhouyu Zhang, in a collab with PKU: Martini 3 CG sims overestimate lipid scrambling, predict it in proteins that don't, and give anomalous binding, from low headgroup polarity. But small parameter refinements fix it. tinyurl.com/m3scramble

Kudos to @ciara__wallis & @yiechanglin for their elegant publication testing #AlphaFold for predicting protein oligomeric states including advice on when it is likely to do well and when it can fail. 🌟🎉🌟🎉 #StructuralBiology #AI #Biophysics tiny.cc/oligos

Excited to share this paper from @yiechanglin showing how lipids can move between bacterial membranes along the bridge like protein TamB. Also happy to be able to post the cool movie. 🎥🌟 #MDsimulations #StructuralBiology doi.org/10.1016/j.bpj.2026.0…

Beginning 2026 with a flipping good paper🚀OSCA/TMEM63 proteins do double duty: they’re ion channels andmechanically activated lipid scramblases helping reshape membranes and survive mechanical stress. 👏@yiechanglin @Charles_D_Cox doi.org/10.1038/s41467-026-6…

Great to see this paper with @whoiselainetao out in print at the Biophysical Journal. Using Alphafold to study conformational transitions in 32 voltage-gated ion channel superfamily members #ionchannel #AI #StructuralBiology sciencedirect.com/science/ar…

2 yrs ago @yiechanglin sent me this of lipid scrambling by OSCA1.2. Now we show it’s common to WT OSCA/TMEM63 proteins, mechanically activated, cholesterol dependent, and protects cells from damaging forces. Awesome collab with @Charles_D_Cox &Zhang lab. tiny.cc/tmem63

🌟We are hiring! Seeking a postdoc to use molecular dynamics and AI to understand how ion channels are regulated by membrane lipids🌟 Join us at @ourANU with amazing collaborators and great working conditions! Apply: tiny.cc/corry. Us: karri.anu.edu.au

We show where chloroquine and peptides bind and help explain the polyspecific transport mechanism. (2/2)

Excited to share @john_d_tanner's new work in Nat Coms! We demonstrate how PfCRT, a polyspecific peptide transporter, turns into a drug transporter for antimalarials like chloroquine and why this causes a fitness cost for the malaria parasite (1/2) tiny.cc/PfCRT

Also bittersweet to announce the final work of @whoiselainetao in our lab, using AF2 to study conformational transitions in 32 voltage-gated channel superfamily members 🤩 we're so excited to watch you Nav-igate the next steps of your career, Dr. Tao 🎩 tiny.cc/VSD-AF2

Thrilled to share our latest preprint from @yiechanglin & @ciara__wallis showing AF2-Multimer and AF3 can quickly & accurately predict the oligomeric states & structures of proteins (& maybe can identify multiple biologically relevant oligomeric states 👀) tiny.cc/oligomers