Today I was honored to present with Stavroula Kousteni the Meet-the-Professor session on Stem Cells ASBMR Task Force Report @ASBMR #ASBMR2024 Thanks to all the participants for a stimulating discussion

@Inserm @UPECactus @IMRB_Mondor @yasminehachemi1 @SimonPerrin15 @Maria_Etell @AnaisJulien15 @ChristianGoritz Funding sources: @NIH_NIAMS @AgenceRecherche #BoneRepair #Immunology #SkeletalStemCells #MusculoskeletalTrauma #ScienceDiscovery

This coordinated process is disrupted in musculoskeletal trauma leading to fibrosis and impaired healing. Modulating macrophage function decreased fibrosis and enhanced bone repair, revealing macrophages as a potential therapeutic target to treat trauma-associated fibrosis.

We report an immune cell atlas of bone regeneration. Using single-nucleus transcriptomics, we uncovered parallel inflammatory responses of macrophages and skeletal stem progenitor cells in the early stages of bone healing.

Our new study is out today in BoneResearch @SpringerNature entitled "Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma". 👉 rdcu.be/dVqVp

We would like to thank everyone involved in this study @Inserm @IMRB_Mondor @UPECactus @InstitutImagine and our funding support @AgenceRecherche @DeptofDefense @NIH_NIAMS @ANR_FRANCE @OTCFoundation

This work opens new therapeutic perspectives for patients with CPT. It also provides exciting new concepts on the role of the periosteum and Schwann cells in bone healing and fibrous nonunion.

We successfully tested a combination of MEK and SHP2 inhibitors to prevent fibrous nonunion in mice

We identified the profibrotic role of Nf1-deficient Schwann cells in driving fibrotic accumulation in CPT via TGFβ.

We elucidated the mechanisms leading to the fibrotic fate of Nf1-deficient periosteal skeletal stem/progenitor cells

In our study, we uncovered that periosteal skeletal stem/progenitor cells and Schwann cells both carry NF1 biallelic inactivation in patients with CPT.

Congenital pseudarthrosis of the tibia (CPT) is a severe pathology affecting children and characterized by spontaneous fractures that fail to heal. Half of patients with CPT are also diagnosed with neurofibromatosis type 1 (NF1), caused by mutations in the NF1 gene.

Our latest publication is out in @ScienceTM. This study from @SimonPerrin15 and co-authors investigated a severe form of bone repair defect and found a very unexpected mechanism involving Schwann cells!

A postdoctoral position in musculoskeletal regeneration and stem cells is open in @ColnotLab #imrb #inserm #upec We look forward to receiving applications for this project integrating functional in vivo analyses, microscopy and single cell transcriptomics

Congratulations to the whole team!

Félicitations à @SimonPerrin15 qui a reçu le Prix de l'Université 2023 @valdemarne_94 pour sa thèse de doctorat réalisée @IMRB @UPECactus et @univ_paris_cite et qui a porté sur le rôle du périoste dans la régénération osseuse et la pseudarthrose congénitale de jambe.