Today I was honored to present with Stavroula Kousteni the Meet-the-Professor session on Stem Cells ASBMR Task Force Report @ASBMR #ASBMR2024 Thanks to all the participants for a stimulating discussion

Our new study is out today in BoneResearch @SpringerNature entitled "Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma". 👉 rdcu.be/dVqVp

We successfully tested a combination of MEK and SHP2 inhibitors to prevent fibrous nonunion in mice

We identified the profibrotic role of Nf1-deficient Schwann cells in driving fibrotic accumulation in CPT via TGFβ.

We elucidated the mechanisms leading to the fibrotic fate of Nf1-deficient periosteal skeletal stem/progenitor cells

In our study, we uncovered that periosteal skeletal stem/progenitor cells and Schwann cells both carry NF1 biallelic inactivation in patients with CPT.

Our latest publication is out in @ScienceTM. This study from @SimonPerrin15 and co-authors investigated a severe form of bone repair defect and found a very unexpected mechanism involving Schwann cells!

A postdoctoral position in musculoskeletal regeneration and stem cells is open in @ColnotLab #imrb #inserm #upec We look forward to receiving applications for this project integrating functional in vivo analyses, microscopy and single cell transcriptomics

Félicitations à @SimonPerrin15 qui a reçu le Prix de l'Université 2023 @valdemarne_94 pour sa thèse de doctorat réalisée @IMRB @UPECactus et @univ_paris_cite et qui a porté sur le rôle du périoste dans la régénération osseuse et la pseudarthrose congénitale de jambe.

Congratulations to @SimonPerrin15 for his travel award and poster presentation « Schwann cells and skeletal stem/progenitor cells in periosteum drive fibrosis and congenital pseudarthrosis of the tibia in NF1 » @ASBMR @Inserm @IMRB_Mondor @UPECactus