@ChangJiangLab

Assistant member @MoffittNews studying redox biology, cancer metabolism and mitochondria.

 Tampa, FL
lab.moffitt.org/jiang/
Joined August 2023
  • Tweets309
  • Following345
  • Followers491
8Media
Chang Jiang 姜畅 retweeted
James Olzmann@OlzmannLabOct 16
Congrats to Maia Kinnebrew and team! 🎉 Genetic screens and mechanistic follow-up reveal how fatty acid metabolism tunes membrane fluidity and accessible cholesterol pools. Happy to have contributed in a small way to this study. nature.com/articles/s41467-0…

Fatty acid metabolism controls plasma membrane cholesterol accessibility via ATGL-dependent...

Nature Communications - Accessible cholesterol levels in the plasma membrane are governed by complex regulatory processes. Here Wijesinghe et al. discover that fatty acid starvation activates ATGL...

nature.com
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James Olzmann@OlzmannLabSep 25
Excited to see this online and to have contributed in a small way! Huge congratulations to @Sulfur_Vladi, Takaaki Akaike & team. Elemental sulfur (S8) accumulates in lipid droplets, & protects against lipid peroxidation and ferroptosis! 🔥 science.org/doi/10.1126/scie…

Mammals produce cyclo-octasulfur to suppress lipid peroxidation and ferroptosis

Elemental sulfur is an evolutionarily ancient metabolite, yet its generation, storage, and function in animals have remained unclear. We show that mammals harbor elemental sulfur in the form of its...

science.org
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Chang Jiang 姜畅 retweeted
Kivanc Birsoy@KivancBirsoySep 15
Why is glutathione, rather than cysteine, the major cellular thiol? Our new work by @ToshiNakamura51 suggests unlike other amino acids, excess cysteine is intrinsically toxic to mammalian cells via mitochondrial iron accumulation. @RockefellerUniv nature.com/articles/s42255-0…

Cysteine excess triggers a mitochondrial iron-dependent cell death

Nature Metabolism - Using a genome-wide CRISPR screen, the authors demonstrate that excess cysteine drives mitochondrial iron accumulation and iron–sulfur cluster failure, triggering a...

nature.com
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James Olzmann@OlzmannLabSep 3
Excited to see our Preview led by Amalia Megarioti online in Cell, highlighting new work showing that polyamines act as endogenous buffers of labile iron to suppress ferroptosis. Congrats to Pushkal Sharma, Whitney Henry, Ankur Jain and team!👏 cell.com/cell/fulltext/S0092…

Metabolite buffering of labile iron governs ferroptosis

Iron abundance alone does not determine ferroptosis sensitivity. In this issue of Cell, Sharma and colleagues identify polyamines as endogenous metabolic buffers that reduce the chemical accessibil...

cell.com
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Chang Jiang 姜畅 retweeted
Dr. Patrick Hwu
@PatrickHwuMDJun 5
#FollowFriday Chang Jiang, PhD, is an Assistant Member in the Department of Molecular Oncology @MoffittNews whose lab studies the role of redox biology and mitochondrial antioxidant systems in cancer therapy resistance. Check out @ChangJiangLab and give her a follow!
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Chang Jiang 姜畅 retweeted
Katherine Aird@airdlabJun 14
Looking for a postdoc? We are recruiting scientists who are finishing their PhD to study how metabolism shapes cancer progression, immunity, and therapeutic resistance. Recent highlight: our Nature paper on αKG tiny.cc/ur15101. Learn more at airdlab.com.

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation

Nature - The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential...

nature.com
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Chang Jiang 姜畅 retweeted
Cell Biology J-Club@cell_clubJun 11
A membrane homeostatic response to lipid overload coordinates fatty acid metabolism biorxiv.org/content/10.64898…

A membrane homeostatic response to lipid overload coordinates fatty acid metabolism

Excess fatty acids can disrupt membrane and organelle function. Cells buffer fatty acid toxicity by synthesizing and storing triglycerides (TGs) in lipid droplets, but their capacity for TG storage...

biorxiv.org
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Chang Jiang 姜畅 retweeted
Cell Reports@CellReportsJun 11
NRF2-mediated inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection dlvr.it/TT02dT

NRF2-mediated inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis...

Pham et al. show that, during Mycobacterium tuberculosis infection, NRF2 activation in alveolar macrophages inhibits MHC II but not MHC I, leading to dampening of antigen presentation and CD4+ T cell...

cell.com
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Chang Jiang 姜畅 retweeted
Molecular Cell@MolecularCellJun 12
Online Now: RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription dlvr.it/TT0yzt
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Liling Wan@LilingWanLabJun 12
Excited to share that our preprint 'RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription' is now online @MolecularCell cell.com/molecular-cell/full… @PennMedCSO @PennCancer @PennEpiInst
Liling Wan@LilingWanLab4 Aug 2025
(1/n) Excited to share our new preprint! We uncover that RNA actively promotes nucleation and function of pathogenic condensates, amplifying locus-specific oncogenic transcription and promoting tumorigenesis. #epigenetics #condensates #cancer #RNA biorxiv.org/content/10.1101/…

RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription

Aberrant chromatin-associated condensates have emerged as drivers of transcriptional dysregulation in cancer, yet the mechanisms regulating their formation and function remain poorly understood....

biorxiv.org
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Chang Jiang 姜畅 retweeted
Cancer Cell@Cancer_CellJun 11
RAS-ing the bar in the treatment of KRAS-mutant cholangiocarcinoma dlvr.it/TT0SfW
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Cancer Cell@Cancer_CellJun 10
Tissue tension fosters macrophage-driven lipid peroxidation-induced DNA damage dlvr.it/TSzVNC
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Molecular Cell@MolecularCellJun 5
Hypoxia-driven lncRNA SHIELD promotes GPX4 translation and protects against ferroptosis in hepatocellular carcinoma dlvr.it/TSv82y
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Chang Jiang 姜畅 retweeted
Brandon Chen, PhD@BrandonTWChenMay 28
Congrats to my friend and ex-@YatrikShahLab lab mate @ChestaJain5 on this impressive work!
Cell Metabolism@Cell_MetabolismMay 27
New! Online now: Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death dlvr.it/TSlWK5
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Excited to share our new @biorxivpreprint from the @BradyLab led by Santanu Ghosh. “Mitochondrial copper stabilizes lipoylated TCA cycle proteins to sustain metabolism and proliferation” biorxiv.org/content/10.64898…
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Excited to share our new @biorxivpreprint from the @BradyLab & @PaulTitchenell lab on MASH, phosphatidylcholine metabolism, and copper biology with @JaclynE_x8 & biorxiv.org/content/10.64898…
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Chang Jiang 姜畅 retweeted
Katherine Aird@airdlabMay 2
Our lab is expanding and hiring both a postdoc and staff scientist! We study how metabolism and cell cycle states drive tumor progression, therapy response, and immune interactions. Philly is a great place to live and do research! See more at: airdlab.com.

Aird Lab

airdlab.com
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Congratulations! ❤️
Kivanc Birsoy@KivancBirsoyApr 17
Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s41556-0…

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis

Nature Cell Biology - Liu, Gad et al. develop an approach to purify the endoplasmic reticulum and integrate genetic, structural, molecular and cell biological analyses to identify SLC33A1 as an...

nature.com
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Chang Jiang 姜畅 retweeted
Kivanc Birsoy@KivancBirsoyApr 17
Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s41556-0…

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis

Nature Cell Biology - Liu, Gad et al. develop an approach to purify the endoplasmic reticulum and integrate genetic, structural, molecular and cell biological analyses to identify SLC33A1 as an...

nature.com
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Chang Jiang 姜畅 retweeted
Yuyang Liu@YuyangLiu1996Apr 17
Check out this amazing work by @shanshanliu1218 and @gadmark !
Gad@gadmarkApr 17
Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. nature.com/articles/s41556-0… 🧵 1/9

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis

Nature Cell Biology - Liu, Gad et al. develop an approach to purify the endoplasmic reticulum and integrate genetic, structural, molecular and cell biological analyses to identify SLC33A1 as an...

nature.com
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