@CayaBissonnette

PhD in Neurosciences, University of Ottawa. Synaptic electrophysiology & cortical plasticity.

researchgate.net/scientific-contributions/2150241959_Lea_Caya-Bissonnette
Joined July 2011
  • Tweets111
  • Following292
  • Followers230
18Media
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique biorxiv.org/content/10.1101/…

Cellular Substrate of Eligibility Traces

The ability of synapses to undergo associative, activity-dependent weight changes constitutes a linchpin of current cellular models of learning and memory. It is, however, unclear whether canonical...

biorxiv.org
7
36
9
144
25,528
Wow, this is great!! Fantastic teaching resource to boot.
Léa Caya-Bissonnette, PhD@CayaBissonnette12 Jul 2024
For a refresher on the great classics, or a glimpse into the future, check out this review by @JCBeique & I on 50 years of Long-term Potentiation, and what the next 50 years might hold! cell.com/current-biology/ful…

Half a century legacy of long-term potentiation

Caya-Bissonnette and Béïque discuss the milestones that have shaped our current understanding of the molecular and cellular basis of long-term potentiation.

cell.com
1
1
913
For a refresher on the great classics, or a glimpse into the future, check out this review by @JCBeique & I on 50 years of Long-term Potentiation, and what the next 50 years might hold! cell.com/current-biology/ful…

Half a century legacy of long-term potentiation

Caya-Bissonnette and Béïque discuss the milestones that have shaped our current understanding of the molecular and cellular basis of long-term potentiation.

cell.com
3
15
1
49
4,015
Léa Caya-Bissonnette, PhD retweeted
John Beninger@jgbeninger19 Feb 2024
Clustering model parameters across hundreds of synapses, we found five functional subtypes of synaptic dynamics in rodents and six functional subtypes in humans which show qualitative overlap (though based on existing data we don’t expect a perfect overlap). 4/10
1
1
3
372
MUST read - Amazing work showing functional clusters of short term plasticity! Congrats @jgbeninger 🎉👏 – at Montréal, Québec
John Beninger@jgbeninger19 Feb 2024
Interested in short-term plasticity? Our recent findings have just been published! With @Neuronaud @mossy_fibers @j_rossbroich Online: cell.com/cell-reports/fullte… 1/10
4
293
Léa Caya-Bissonnette, PhD retweeted
Richard Naud@NeuroNaud11 Jan 2024
If you're interested in dendritic computation, our most recent findings are just published! With @Z_Friedenberger and at @NatComputSci Direct access: rdcu.be/duzz9 Online: nature.com/articles/s43588-0…
6
34
118
10,622
Léa Caya-Bissonnette, PhD retweeted
Nima Raman@RamanNima13 Dec 2023
I’m pretty overdue but this photo reminds me of this exciting day when I had a chance to moderate the trainee talks along with @CayaBissonnette at Centre for Neural Dynamics Research Spotlight organized by @uOttawaBMRI, & enjoy a beautiful talk by @nspruston back in September! – at Ottawa, Ontario
1
9
644
Léa Caya-Bissonnette, PhD retweeted
Neuroskeptic 🇺🇦
@Neuro_Skeptic23 Sep 2023
A new theory of serotonin function: it encodes "cumulative future reward" aka state value biorxiv.org/content/10.1101/… Compared to dopamine, serotonin is a lot more mysterious
5
38
2
150
27,884
Great piece of work by @efharkin_ on serotonin and value encoding 👏 – at Ottawa, Ontario
Emerson F. Harkin@efharkin_21 Sep 2023
What do you get when you combine RL and predictive coding? The in vivo activity patterns of serotonin neurons. Excited to share a new theory and analysis to back it up! doi.org/10.1101/2023.09.19.5… With @NeuroNaud and @JCBeique in collab with @grossmancooper & @JeremiahYCohen. 🧵
2
293
Léa Caya-Bissonnette, PhD retweeted
Toviah Moldwin@TMoldwin10 Aug 2023
Replying to @CayaBissonnette @NeuroNaud @JCBeique
Great work! We also have a calcium-dependent model of a different aspect of BTSP here: biorxiv.org/content/10.1101/…, I'd be interested in hearing your thoughts - maybe you can DM me and we can talk over Zoom some time?

A Generalized Framework for Calcium-Based Plasticity Describes Weight-Dependent Synaptic Changes in...

The brain modifies synaptic strengths to store new information via long-term potentiation (LTP) and long-term depression (LTD). Evidence has mounted that long-term plasticity is controlled via...

biorxiv.org
1
2
2
250
Léa Caya-Bissonnette, PhD retweeted
TTchumatchenko@TTchumatchenko6 Jul 2023
Replying to @NeuroNaud
Very interesting paper, thanks for sharing! So cool that you are also venturing into the molecular world and building a bridge to the circuit level.
1
1
2
354
Léa Caya-Bissonnette, PhD retweeted
Ching-Lung Hsu@hiallen7210 Jul 2023
Beautiful work by @CayaBissonnette @NeuroNaud @JCBeique Cellular Substrate of Eligibility Traces biorxiv.org/content/10.1101/…

Cellular Substrate of Eligibility Traces

The ability of synapses to undergo associative, activity-dependent weight changes constitutes a linchpin of current cellular models of learning and memory. It is, however, unclear whether canonical...

biorxiv.org
2
4
583
Léa Caya-Bissonnette, PhD retweeted
Justin O'Hare@JustinKOHare6 Jul 2023
Intracellular calcium steadily making its overdue comeback to the big stage 🫡🍿
Léa Caya-Bissonnette, PhD@CayaBissonnette5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique biorxiv.org/content/10.1101/…

Cellular Substrate of Eligibility Traces

The ability of synapses to undergo associative, activity-dependent weight changes constitutes a linchpin of current cellular models of learning and memory. It is, however, unclear whether canonical...

biorxiv.org
1
2
5
1,317
Léa Caya-Bissonnette, PhD retweeted
Sébastien Maillé@sebmaille5 Jul 2023
Amazing work! Congrats @CayaBissonnette, @NeuroNaud and @JCBeique 🥳🤩
Léa Caya-Bissonnette, PhD@CayaBissonnette5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique biorxiv.org/content/10.1101/…

Cellular Substrate of Eligibility Traces

The ability of synapses to undergo associative, activity-dependent weight changes constitutes a linchpin of current cellular models of learning and memory. It is, however, unclear whether canonical...

biorxiv.org
1
3
428
Léa Caya-Bissonnette, PhD retweeted
Michael Lynn@MichaelBLynn_5 Jul 2023
Outstanding work by great people - a cellular model of eligibility traces! Check it out 🎉
Léa Caya-Bissonnette, PhD@CayaBissonnette5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique biorxiv.org/content/10.1101/…

Cellular Substrate of Eligibility Traces

The ability of synapses to undergo associative, activity-dependent weight changes constitutes a linchpin of current cellular models of learning and memory. It is, however, unclear whether canonical...

biorxiv.org
2
5
1,316
Léa Caya-Bissonnette, PhD retweeted
Alessandro Galloni@argalloni22 Apr 2022
Part 2 of my PhD finally published! w/@ranczlab & @ZhiwenNeuron How do feedforward and feedback connections target L5 neurons? 🧵 TLDR; Dendritic targets are tightly specified, but may surprise you. “FF = basal, FB = apical tuft” is not a universal rule! bit.ly/tL5b

Dendritic Domain-Specific Sampling of Long-Range Axons Shapes Feedforward and Feedback Connectivity...

Feedforward and feedback pathways interact in specific dendritic domains to enable cognitive functions such as predictive processing and learning. Based on axonal projections, hierarchically lower...

jneurosci.org
4
12
2
74
Léa Caya-Bissonnette, PhD retweeted
Emerson F. Harkin@efharkin_1 Mar 2023
What does the serotonin system compute? 🤔 🎉 I'm excited to finally be able to share a long-term project with @JCBeique and @NeuroNaud to create an experimentally-constrained bottom-up model of the dorsal raphe nucleus, just published in @eLife!🎊 doi.org/10.7554/eLife.72951 1/13
3
32
4
114
30,783
Léa Caya-Bissonnette, PhD retweeted
Alessandro Galloni@argalloni5 Jul 2023
Super cool results! Glad to see the full paper out after the preview we got at Cosyne
Léa Caya-Bissonnette, PhD@CayaBissonnette5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique biorxiv.org/content/10.1101/…

Cellular Substrate of Eligibility Traces

The ability of synapses to undergo associative, activity-dependent weight changes constitutes a linchpin of current cellular models of learning and memory. It is, however, unclear whether canonical...

biorxiv.org
1
2
5
974
Léa Caya-Bissonnette, PhD retweeted
Emerson F. Harkin@efharkin_6 Jul 2023
How can individual neurons learn to associate events that don't happen at exactly the same time? 🤔 Léa provides a mechanistic answer: synaptic loading and unloading of ER calcium stores. 😲
Léa Caya-Bissonnette, PhD@CayaBissonnette5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique biorxiv.org/content/10.1101/…

Cellular Substrate of Eligibility Traces

The ability of synapses to undergo associative, activity-dependent weight changes constitutes a linchpin of current cellular models of learning and memory. It is, however, unclear whether canonical...

biorxiv.org
1
4
301
Léa Caya-Bissonnette, PhD retweeted
Richard Naud@NeuroNaud6 Jul 2023
Few-shot plasticity in the cortex unfolds with big calcium events. With these rare events, calcium stores act as temporal buffers, extending the timescale for associating pre&post activity to seconds. But there is much more in Léa's work. Check it out!
Léa Caya-Bissonnette, PhD@CayaBissonnette5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique biorxiv.org/content/10.1101/…

Cellular Substrate of Eligibility Traces

The ability of synapses to undergo associative, activity-dependent weight changes constitutes a linchpin of current cellular models of learning and memory. It is, however, unclear whether canonical...

biorxiv.org
1
5
27
3,371
Léa Caya-Bissonnette, PhD retweeted
Randy Bruno
@TheBrunoCortex6 Jul 2023
Possible mechanism of behavioral timescale plasticity!
Léa Caya-Bissonnette, PhD@CayaBissonnette5 Jul 2023
Interested in behavioral timescale synaptic plasticity (BTSP)? Associative learning? Eligibility traces? Temporal credit assignment problem?! Check out our preprint 👇! (1/13) #synapticplasticity #BTSP @NeuroNaud @JCBeique biorxiv.org/content/10.1101/…

Cellular Substrate of Eligibility Traces

The ability of synapses to undergo associative, activity-dependent weight changes constitutes a linchpin of current cellular models of learning and memory. It is, however, unclear whether canonical...

biorxiv.org
2
8
1,411
Load more