@CaretteLab

Studying host pathways that are critical for viral infection to reveal virus host relationships, illuminate basic cellular biology, and inform antiviral design

 Stanford, CA
med.stanford.edu/carettelab.html
Joined September 2022
  • Tweets67
  • Following160
  • Followers328
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Finally! It is happening! After 6 years of hard work by formidable teams in 13 institutions @RESOLUTE_IMI, we have ordered and validated the results and are able to share the FOUR (4) papers aimed at assigning functional properties to each human SLC #membranetransporter
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Introducing new #ProgramLeaders! Meet Lily, a 4th year PhD candidate in the #MicrobiologyandImmunology. With a BS #biomedicalengineering and #computationalbiology from @WUSTL, she studies host-pathogen interactions by characterizing viral proteins and host factors using cryo-EM
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Tenure Day 🎊! I am incredibly grateful to all the Wang lab members who form a thoughtful, dynamic, and motivating team. Time to celebrate!
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Thrilled to see our paper "A Proximity Proteomics Pipeline with Improved Reproducibility and Throughput" published! It describes the automated enrichment of biotinylated proteins in a 96-well plate format for spatial proteomics and protein interactions. embopress.org/doi/full/10.10…
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Check our recent publication about how the antibody response to Omicron-based boosters in humans is imprinted by immunizations with historical mRNA-1273 vaccines. Congrats to Chieh-Yu! #WUSM #COVID nature.com/articles/s41586-0…
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Congrats to Wenjie & team! Excited to share the the work entitled, "MYADM binds human parechovirus 1 and is essential for viral entry" that was published in Nature Communications today. Credit to all authors!  nature.com/articles/s41467-0…

MYADM binds human parechovirus 1 and is essential for viral entry

Nature Communications - Host factors required for parechovirus entry are not well understood. Here, the authors identify MYADM as an essential host entry factor that directly binds human...

nature.com
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Interested in small RNA viruses ? Come work with us. Contact us and we will help you through the application! marie-sklodowska-curie-actio…
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Excited to shared our latest manuscript describing the discovery of a receptor for parechoviruses rdcu.be/dFTMO. Parechoviruses belong to the same family as poliovirus and are increasingly linked to neurological disease. (1/2)
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Congratulations to lead author @WenjieQiao and collaborators Chris, Youlim, @JamesZengel, @sding88, and Harry.
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Fantastic opportunities in a super exciting young lab! (And the neighbors are nice too) 👇 – at Shoreline, WA
Chris Lapointe@C_P_Lapointe3 Jan 2024
The Lapointe Lab @FredHutch in Seattle has two openings for postdoctoral scholars to examine mRNA & translational control using single-molecule or high-throughput (co-mentored w/ @arvind_rasi) approaches. More info here: research.fredhutch.org/lapoi…

Join

Join the Lapointe Lab at Fred Hutchinson Cancer Center.

research.fredhutch.org
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Applications are open for the 2024 Stanford Summer Research Program (#SSRP). 📝 #SSRPAMGENScholars are fully-funded, on this research-intensive, eight-week summer journey taking place on @Stanford’s campus 💡 Learn more at ssrp.stanford.edu. Apply by February 1st, 2024
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Deep sadness over @BrettLindenbach’s passing 💔 His love of virology was truly inspiring. Please consider supporting Brett’s legacy by contributing to the Brett Lindenbach Virology Fund, to help train the next generation of scientists in virology. medicine.yale.edu/news-artic…

The Brett Lindenbach Virology Fund

The Brett Lindenbach Virology Fund will support an endowed lecture and training that honors Brett’s contributions to virology at Yale and beyond. In order for

medicine.yale.edu
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Carette Lab retweeted
Craig Wilen@WilenLab17 Dec 2023
We will miss you Brett. ⁦@BrettLindenbach⁩ legacy.com/us/obituaries/leg…

Brett Lindenbach Obituary (1968 - 2023) - Legacy Remembers

View Brett Lindenbach's obituary, send flowers and sign the guestbook.

legacy.com
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Please share! We're recruiting a tenure-track junior faculty member to join our Institute Scholar community at Sarafan ChEM-H @Stanford! We encourage applicants working at the interface of science, engineering, & medicine to apply: stanford.io/3PXaznX
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ALT Decorative image

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Check out this work from our lab on genome-wide single-gene CRISPR/Cas9 knockout screens to comprehensively interrogate CFTR- F508del ERAD. biorxiv.org/content/10.1101/…

Small molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding states

Over 80% of people with cystic fibrosis (CF) carry the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR), a chloride ion channel at the apical plasma membrane (PM) of...

biorxiv.org
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Carette Lab retweeted
Mehle Lab@MehleLab1 Sep 2023
We love genetic approaches to define virus:host interactions. Knockout screens are powerful, but...technical constraints limit what you can find. Could we devise a screen where viral fitness pinpoints the key regulators of replication? (spoiler - yes cell.com/cell-host-microbe/f…) 1/10

Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza...

King et al. develop transcriptional regulation by pathogen-programmed Cas9 (TRPPC) where viruses encoding sgRNAs alter host gene expression to affect their own fitness. A fitness-based TRPPC screen...

cell.com
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Congratulations to Professor Ann Palmenberg, who retires this week after more than 40 years @UWBiochem & @MadisonVirology! Palmenberg built her lab & career around unveiling the enzymes & mechanisms responsible for controlling viruses. Her research established the foundation ➡️
Ann Palmenberg

ALT Ann Palmenberg

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I had the pleasure to review the lysosomal enzyme trafficking pathway and its role in genetic diseases, cancer and viral infections with two leading experts, Thomas Braulke and Jan Carette @CaretteLab for @TrendsCellBio. You can access the article here: authors.elsevier.com/a/1hRTA…
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Carette Lab retweeted
ScheelLab@ScheelLab5 Jul 2023
Excited to share our labs first @Nature paper! In collaboration with @VintherLab we show that hepatitis C virus #RNA is capped with FAD protecting it from innate immune sensing. rdcu.be/df8p5 Congrats Anna Sherwood and Lizandro Rivera-Rangel 👏🏻🍾 #HCV @UCPH_health
nature
@Nature5 Jul 2023
Nature research paper: Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide go.nature.com/44nyQYy

Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide

Nature - Hepatitis C virus utilizes flavin adenine dinucleotide as a non-canonical initiating nucleotide for the viral RNA polymerase, resulting in 5′ capping of viral RNA, which provides...

nature.com
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Congratulations to Dr. Kellie Ann Jurado, one of the winners of the Ann Palmenberg Junior Investigator Award!
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