Stem cell biologist at the Hebrew University of Jerusalem. Interested in nuclear reprogramming and early embryonic development. Proud father of three.
Jerusalem
Joined May 2018
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nature.com/articles/s41586-0…
(1/n) Ever wonder how transcription factors locate, "invade," and activate their enhancers during cell fate acquisition? 🧬🚀Check out our latest collaborative work with the Soufi lab, now published in @Nature!
I'm excited to share that I've been promoted to Full Professor at the Hebrew University!
I'm incredibly grateful to my collaborators, and especially the amazing members of my lab, past and present. This milestone is as much yours as it is mine.
Now, back to the science! 🚀🧬
Yossi Buganim retweeted
🥁We are recruiting PhD students/Postdocs with strong proven background in developmental/molecular/cell biology & related areas, for various projects- check out our lab website👇🏼
We offer: competitive stipends, super equipped lab, fun international team!
yanivelkoubylab.com/
Extremely proud of my MD-PhD student, Hazar Yassen, who has won the National President’s Award for Excellence and Scientific Innovation. Keep up the outstanding work, Hazar!
Yossi Buganim retweeted
🔥A second preprint from our lab this week!
Especially proud of this one that helps unlock a black box in #reproduction.
We propose a morphogenetic framework for #oocyte production from germline stem cells in #zebrafish and from progenitors in humans.
>
researchsquare.com/article/r…
Yossi Buganim retweeted
Are you passionate about harnessing innovative brain organoid technologies to explore the mysteries of neurodegenerative disorders? Would you like to pursue a Postdoc, MSc or PhD degree in Medical Neuroscience? Join our exciting journey of discovery!
Yossi Buganim retweeted
🐟🐟🐟
We are looking for the floxed dnStat3 line (pd59Tg) - Tg(actb2:LOXP-DsRed-STOP-LOXP-dnstat3-GFP), which was generated by the Poss lab (or similar).
If anyone maintains the line and able to kindly share embryos, that would be much appreciated. Thanks!
@ZebrafishRock
Yossi Buganim retweeted
New study from the lab! All kinds of good and bad and surprising things happen after sleeve gastrectomy bariatric surgery, but happens to the stomach itself? Does it “know” it has been sleeved? How?
nature.com/articles/s41467-0…
Yossi Buganim retweeted
Super interesting work and so relevant to cell fate decision lovers like me!!
nature.com/articles/s41586-0…
(1/n) Ever wonder how transcription factors locate, "invade," and activate their enhancers during cell fate acquisition? 🧬🚀Check out our latest collaborative work with the Soufi lab, now published in @Nature!
Yossi Buganim retweeted
New function for non-coding or "Junk" neutral DNA.
A previously uncharacterized DNA element adjacent to enhancers, termed the "signpost", functions to guide transcription factor binding.
nature.com/articles/s41586-0…
(1/n) Ever wonder how transcription factors locate, "invade," and activate their enhancers during cell fate acquisition? 🧬🚀Check out our latest collaborative work with the Soufi lab, now published in @Nature!
(3/n) Our study reveals that transcription factor combinations use distinct strategies to locate enhancers:
OSKM factors leverage motif orientation within chromatin loops to target pluripotent enhancers.
GETM factors use looping junctions to locate trophectoderm enhancers.
Yossi Buganim retweeted
Ananda Labs, founded by @HebrewU's Prof. Yossi Buganim, was featured in @ISRAEL21c for its groundbreaking research on reversing aging. Their epigenetic reprogramming tech targets age-related diseases, rejuvenates skin, and boosts immune health.
Read more: heyor.ca/m63iiR
Yossi Buganim retweeted
New study by Prof. @BuganimLab and Prof. Howard Cedar from #HUJI, alongside Prof. Ben Stanger from @Penn, reveals that DNA methylation patterns pose a major challenge in reprogramming specialized cells, a key step in regenerative medicine.
For the full article👇
shorturl.at/0DTPz
Happy to share our recent collaborative study with the Cedar and Stanger labs, identifying the barrier responsible for incomplete epigenetic reprogramming in both in vitro and in vivo transdifferentiation models.
pnas.org/doi/10.1073/pnas.24…
Interestingly, the lack of demethylation, rather than de novo methylation, on key developmental regulatory elements, plays a crucial role in the incomplete reprogramming process. Kudos to all the authors for this surprising and important discovery!👏 #Epigenetics #Reprogramming
Yossi Buganim retweeted
🙌 Congratulations to Dr. Yossi Buganim (@BuganimLab) & team who were awarded a $600,000 grant from @LEOFondet to support groundbreaking research on #fibroblast dysfunction in aging skin.
Dig into their research. 👇
bit.ly/3WfmPmP
