@MansourLab

Lab for Stem Cells, Brain Generation & Degeneration Research @hujimed @hebrewu. We use human stem cell-based technologies to study neurological disorders

 Jerusalem
mansour-lab.com
Joined February 2021
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  • Following498
  • Followers437
7Media
Check out our new study published in @CellCellPress.
Abed A. Mansour
@mansour_abed_A11 May 2023
Very happy and excited to share our paper @CellCellPress. In brief, we developed a human-based, stem cell-derived brain organoid in vivo system for studying neuroinflammatory mechanisms in health and disease @salkinstitute @Hujimed @MedNeuroHUJI cell.com/cell/fulltext/S0092…

An in vivo neuroimmune organoid model to study human microglia phenotypes

Schafer et al. present an organoid-based xenotransplantation platform to study human brain-environment-dependent and disease-associated microglia phenotypes under in vivo conditions.

cell.com
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We are recruiting students and postdoctoral fellows to explore the molecular and cellular mechanisms that shape neurodevelopment. Our research harnesses the unparalleled genetic power of Drosophila to uncover fundamental principles of neural circuit assembly and remodeling.
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Check out our lab’s new website! If you're interested in our work, consider joining us — we’re recruiting ;) mansour-lab.com
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We are hiring: Research Associate – Mansour Lab (HUJI, Jerusalem) We’re looking for Research Associate to work on iPSC-derived neural organoid & neuroimmune models to study mechanisms of neurodegenerative disorders. To apply: send CV via email: [email protected]
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Mansour Lab retweeted
Cell@CellCellPress15 Dec 2025
In the latest issue! Fate and state transitions during human blood vessel organoid development dlvr.it/TPqjMd

Fate and state transitions during human blood vessel organoid development

(Cell 188, 3329–3348.e1–e18; June 12, 2025)

cell.com
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New preprint from the lab! We discovered transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to surface expansion in humans 1/ doi.org/10.1101/2025.10.07.6…
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I'm excited to share our new preprint on LagTag, a method that recovers both past and present chromatin states from the same mammalian cells. biorxiv.org/content/10.1101/…
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Are you passionate about harnessing innovative brain organoid technologies to explore the mysteries of neurodegenerative disorders? Would you like to pursue a Postdoc, MSc or PhD degree in Medical Neuroscience? Join our exciting journey of discovery!
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Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures: Cell Reports cell.com/cell-reports/fullte…

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons...

Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts....

cell.com
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Proud of @khamaisi_moran and Amitay Cohen for presenting two talks at the Young Academy of Science and Medicine. Moran was the only undergrad Medical student to be selected to give a talk! Well done, the Mansour lab is proud of you!
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A Postdoctoral Research Associate post is available in the lab in Human Organoid Neurobiology and ALS/MND Research - see our job advert in Nature Careers nature.com/naturecareers/job…

Postdoctoral Research Associate - Cambridge, Cambridgeshire

A Postdoctoral Research Associate position is available for 2 years in human 3D organoid-based disease modelling in Amyotrophic Lateral Sclerosis (...

nature.com
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Mansour Lab retweeted
Evgeny Kvon@evgenykvon6 Jan 2025
Our preprint is out nature.com/articles/s41467-0… In a new set of experiments, we screened a panel of rare and common variants from patients with Autism and identified variants in enhancers of OTX2 & Mir9-2 that reproducibly alter their activity in vivo! Huge congrats to @ewholling
Evgeny Kvon@evgenykvon11 Dec 2023
How to test the functional impact of noncoding variants in vivo? Happy to share our work led by @ewholling where we developed dual-enSERT, a new method that enables rapid, quantitative comparison of human enhancer variant activities in live mice. Check this Tweetorial for details
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Are you passionate about harnessing innovative brain organoid technologies to explore the mysteries of neurodegenerative disorders? Would you like to pursue an MSc or PhD degree in Medical Neuroscience? Join our exciting journey of discovery!
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Excited and relieved to share with you our microglia-sufficient brain organoid work just online @Nature nature.com/articles/s41586-0… IPSC-derived microglia reprogram them metabolically! And make them mature faster!
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I am excited to show you these beautiful movies! A great effort together with @TweetPetrStrnad at @ViventisMicro to design a new #lightsheet for long term high throughput live imaging of large specimens #organoids, #embryoids and entire animals #hydra. dlvr.it/Swnqmw
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Programmable RNA-guided DNA endonucleases are widespread in eukaryotes and their viruses
Omar Abudayyeh
@omarabudayyeh28 Sep 2023
We’ve always wondered if there was something beyond CRISPR for genome editing. We now report that animals, plants, fungi and viruses have troves of programmable nucleases capable of efficient gene editing in human cells An update on our Fanzor work! science.org/doi/10.1126/scia… 1/7

Programmable RNA-guided DNA endonucleases are widespread in eukaryotes and their viruses

Fanzor is an RNA-guided DNA endonuclease widespread in eukaryotes and their viruses.

science.org
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Mansour Lab retweeted
Mansour Lab@MansourLab17 Jun 2023
3/ Candidates with prior experience in stem cells, tissue culture, microscopy, and/or next-generation sequencing would be an asset. If you are interested, please send your application and CV to: [email protected]. @ERC_Research funded project!
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Master’s position has been filled for this year. PhD and Postdoc candidates are welcome to apply!
Mansour Lab@MansourLab17 Jun 2023
1/ "Join the Mansour lab at Hebrew University's Dept of Med. Neurobiology! We're recruiting! The Mansour Lab is currently seeking one MS.C., one Ph.D. student, and one postdoc to join our team. @IMRIC_HUJ @MedNeuroHUJI
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iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons #ALS #diseasemodeling cell.com/cell-reports/fullte…

iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem...

Amyotrophic lateral sclerosis causes motor neuron degeneration but leaves most other neurons intact. Held et al. find that familial ALS mutations cause distinct RNA profiles in iPSC-derived motor...

cell.com
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Big Congratulations to our talented 1st undergrad student Moran Khamaisa for being accepted on Fac. of Medicine @Hujimed as a MEDICAL student!! Mabrook and well deserved Moran!
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Mansour Lab retweeted
Federico Soria@SoriaFN11 Jul 2023
3D segmentation and analysis of cortical mouse #microglia with 3D ImageJ Suite. The free, open source software by Thomas Boudier is available as an ImageJ/FIJI plugin (mcib3d.frama.io/3d-suite-ima…).
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