@LlorcaLab

Macromolecular Complexes in DNA Damage Response Group. Structural Biology Programme @CNIOStopCancer

 Madrid, Spain
goo.gl/qeRMLu
Joined February 2019
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starting to understand the structural bases of CONCR lncRNA in DNA replication and chromatid cohesion. A collaboration between @MaiteHuarteLab @FMorenoHerrero @OscarLlorcaCNIO @ChillonIsabel and the support of @FundlaCaixa
Molecular Cell@MolecularCell
Aug 28
Online Now: CONCR lncRNA organizes a 3′-end structural domain that engages DDX11 for DNA replication and sister chromatid cohesion dlvr.it/TVD6XG
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A closer look at the mechanism of microtubule nucleation💫. Thrilled to share our new work revealing CM1-activated gTURC. Great collaboration with @sernarina, @DeBritoClaudia, Thomas Surrey and @LudersLab. @CNIOStopCancer @CRGenomica @IRBBarcelona nature.com/articles/s41467-0…

Structural basis of human γTuRC closure during CM1-activated microtubule nucleation

Nature Communications - Here the authors show that CM1 activates human γTuRC by facilitating its complete closure as the nascent microtubule assembles: high-resolution cryo-EM identifies...

nature.com
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Our take on the struture of the R2T complex 🌱 Now out in @Structure_CP! A fun collab led by @alopezperrote and the @AlabadiDavid lab at @IBMCP . Check it out in the next post 👇
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Link to the paper: cell.com/structure/fulltext/…
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The γTuRC saga goes on! This time, we used cryoEM to describe how CDK5RAP2 helps nucleating microtubules by activating the γTuRC nucleator. Another tour de force led by @sernarina and Fabian Zimmermann and a fun collab with @LudersLab @IRBBarcelona. authors.elsevier.com/c/1jpyq…
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Join us in sunny Madrid☀️ on May 2025 for "Machines acting on DNA and RNA" at the @CNIOStopCancer All things D/RNA! 🧬Replication + transcription + translation + chromatin + repair + processing🧬 Org: @OscarLlorcaCNIO @rfleiro @NogalesLab +info below 👇
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Full info, speakers and registration deadlines in: cnio.es/en/eventos/machines-…

Machines acting on DNA and RNA, a molecular mechanistic perspective (#CFM_MolMech)

cnio.es
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📢Buscamos persona interesada en realizar la tesis doctoral @CIB_CSIC. Ofrecemos contrato predoctoral de 4 años (FPI) para estudiar los mecanismos moleculares de la transposición del ADN usando crio-microscopía electrónica #PIF2024 + info: csic.es/es/formacion-y-emple… RT por favor 🙏
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Junior Group Leader positions for AI/BigData, cancer-oriented researchers are available at @CNIOStopCancer. Many fields (Structural Bio, Protein Design, Genomics, Imaging...) are welcome! 🤗 Apply using the link below 👇 and help us spread the word! cnio.es/en/empleo/junior-gro…
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Thrilled to share our last work @CellRepPhysSci Revealing the molecular mechanism of an anti-tumoral compound inhibiting our favourite system, RUVBL1/2 (at 2.4 Å resolution)🔥 All-@LlorcaLab work led by @CarmenBePaper and @alopezperrote Link below 👇 doi.org/10.1016/j.xcrp.2024.…
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And a movie with those beautiful high-res densities 🤓
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And also... 🔥pre-print alert🔥 We take a look at our favourite system in plants🌱, the R2T complex, an HSP90 co-chaperone. A study led by @alopezperrote (@CNIOStopCancer) and Alberto Palacios (from @AlabadiDavid's lab at @IBMCP). Check it out 👇 biorxiv.org/content/10.1101/…

The structure of the R2T complex reveals a different architecture of the related HSP90 co-chapero...

Heat shock protein 90 (HSP90) is a molecular chaperone that contributes to the maturation and activation of substrates in multiple cellular pathways. Its activity is supported by various co-chapero...

biorxiv.org
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🔥Paper alert🔥 Another fruitful collaboration with our friends in M. Palacín's lab. Link below 🔗👇 A study led by María Martínez Molledo (@CNIOStopCancer) and Josep Rullo (@IRBBarcelona) elucidating the cryoEM structure of Asc1/CD98hc transporter. Supported by @FundlaCaixa
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And here goes the link to the paper in @NatureComms 📰 nature.com/articles/s41467-0…

Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter

Nature Communications - Asc1/CD98hc is a key regulator of small neutral amino acid transport in the brain and adipose tissue. Here, authors report the structure of semi-occluded hAsc1/CD98hc and...

nature.com
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Hi, we have uploaded a preprint on @bioRxiv_biochem that you may find interesting. It's the result of a fruitful collaboration (@IBMCP) with @LlorcaLab (@CNIOStopCancer) aimed at understanding the role of the HSP90 cochaperone R2T in plants.👇
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Double celebration today in the lab! 🎉 Today, our senior postdoc María I. Daudén received the "AECC researcher" grant, followed by our undergrad Celia Varela, also receiving the "AECC lab internship" grant. Proud of you! #TodosContraElCancer @ContraCancerEs @ContraCancerMad
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Llorca lab retweeted
Llorca lab@LlorcaLab
8 Feb 2024
🧬REGISTRATION OPEN🧬 ✈️Come to the @CNIOStopCancer for our Molecular Chaperones in Cancer and Protein Quality Control meeting. ☀️Visit sunny Madrid during spring and enjoy our amazing lineup of speakers. Do not miss it, 10-12 June!! cnio.es/en/eventos/molecular…
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🧬REGISTRATION OPEN🧬 ✈️Come to the @CNIOStopCancer for our Molecular Chaperones in Cancer and Protein Quality Control meeting. ☀️Visit sunny Madrid during spring and enjoy our amazing lineup of speakers. Do not miss it, 10-12 June!! cnio.es/en/eventos/molecular…
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PAPER ALERT🔥 We took a deep dive into the microtubule 🔍 using cryoEM ❄️🔬to capture the earliest steps of nucleation by the γTuRC complex. With @sernarina and @DeBritoClaudia leading the way. Proud of our collab with the @surrey_lab at the @CRGenomica ! science.org/doi/10.1126/scie…

Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation

Cryo–electron microscopy structures provide insights into the mechanism of microtubule nucleation by the human γ-tubulin ring complex.

science.org
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more replies
We are so incredibly proud of @sernarina. Not only is she a cryoEM powerhouse, but she's also a caring mentor and labmate. Definitely a role model. Thanks for your hard work 💕
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When your paper gets into @ScienceMagazine we take the red carpet out in the lab...
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