@BoelLab

Our principal interest is to understand the fundamental aspect of protein synthesis mechanisms and regulations.

 @ibpcF Paris, France
ibpc.fr/UMR8261/AccueilEN/Theme%20GB/Theme.html
Joined February 2019
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  • Following227
  • Followers225
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Our timely contribution to the growing body of YebC2/TACO1 literature 🤩! YebC2 is a third factor that prevents ribosome stalling at prolines. Associates with 70S and important for fitness in absence of EF-P and YfmR. biorxiv.org/content/10.1101/…

YebC2 resolves ribosome stalling at polyprolines independent of EF-P and the ABCF ATPase YfmR

Polyproline motifs are essential structural features of many proteins, and recent evidence suggests that EF-P is one of several factors that facilitate their translation. For example, YfmR was...

biorxiv.org
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Activity, structure, and diversity of Type II proline-rich antimicrobial peptides from insects | EMBO reports embopress.org/doi/full/10.10…

Activity, structure, and diversity of Type II proline-rich antimicrobial peptides from insects

EMBO Reports - Apidaecin 1b (Api), the first characterized Type II Proline-rich antimicrobial peptide (PrAMP), is encoded in the honey bee genome. It inhibits bacterial growth by binding in the...

link.springer.com
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This is really a stunning paper. Cyanobacteria exposed to shorter days (in the lab) "rewire" their membrane lipids to anticipate cold weather. When those cells are plunged into cold water, they have "two or three-times higher survival" than cells exposed to longer days.
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Our collaboration with @WilsonLab2 and @vpelech is out in @NAR_Open! The ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArg and tRNALys isoacceptors in the P site academic.oup.com/nar/advance…

The ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArg and...

Abstract. The efficiency of translation termination is determined by the nature of the stop codon as well as its context. In eukaryotes, recognition of the

academic.oup.com
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Congrats to @biozentrum @snsf_ch Ambizione Group Leader @FlorentWaltz on this stunning study🤩 of respirasome structure & organization inside native cells! It's amazing how quickly in situ #cryoET is advancing. Read Florent's thread🧵 for the high-resolution details🔎🦠 #TeamTomo
Florent Waltz@FlorentWaltz5 Sep 2024
Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.1101/…
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Principal Investigator @gagnon_lab and researchers at @utmbhealth use cryogenic-electron microscopy to elucidate the mechanism of GDP dissociation from RF3 catalyzed by the Escherichia coli 70S-TC. buff.ly/4dxEqwm
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Tour-de-force by @Jonatha31791089 enabling visualization of protein folding within cells by cryo-ET. Great collaboration with @MPI_Biochem colleagues, just out @Nature rdcu.be/dRAQ8
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Here, Koch lab reports on bacterial ribosome hibernation. They show that the membrane-tethering hibernation factors YqjD/ElaB/YgaM, discovered by Wada in E. coli, are widely conserved in proteobacteria and likely target the ribosomal peptide tunnel👍 biorxiv.org/content/10.1101/…
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Out now in @PNASNews we used Tn-seq to identify genetic interactions with EF-P in B. subtilis. We found that 1) the ABCF YfmR (Uup) is required in absence of EF-P in some conditions pnas.org/doi/10.1073/pnas.23…
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Bacterial housekeeping ABCFs are tricky targets. What do they do in the cell? Which ribosomal stalls do they resolve? This is our take on the subject in Bacillus subtilis. biorxiv.org/content/10.1101/…

Resolution of ribosomal stalling by ABCF ATPases YfmR and YkpA/YbiT

Efficiency of protein synthesis on the ribosome is strongly affected by the amino acid composition of the assembled amino acid chain. Challenging sequences include proline-rich motifs as well as...

biorxiv.org
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The paper with our wonderful collaborators @WislonLab2 and @gem_atkinson on the Pth-catalyzed nascent chain release is out. cell.com/molecular-cell/full…

Peptidyl-tRNA hydrolase is the nascent chain release factor in bacterial ribosome-associated...

Svetlov et al. show that, following ribosome splitting, peptidyl-tRNA that remains stuck inside the large ribosomal subunit is released by peptidyl-tRNA hydrolase (Pth). This release requires the...

cell.com
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My first review with @InnisLab and @ThibaudRenault is now out! Thank you to the team for the enriching and fun times writing and discussing 😄 Happy reading this new year!
good papers@paperperday31 Dec 2023
The ribosome as a small-molecule sensor sciencedirect.com/science/ar…
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Check out our latest: Using smFRET, we determine an entirely new mechanism for mRNA activation. As part of this work, we assign novel functions for each of the eIF4F components, including a 'hopping' activity of eIF4G and a 'strippase' activity of eIF4A. 🔬biorxiv.org/content/10.1101/…
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😯Sydney Brenner (Nobel Prize winner) was not a fan of Systems Biology. Systems Biology: To study a drum in the next room, record the sounds and reconstruct the physical properties of the drum. Experimental science: Get in, get hold of the drum, get its structure and play it.
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Insects such as the fruit fly Drosophila produce the antimicrobial peptide drosocin, which bears an O-glycosylation that is critical for its ability to interact with the ribosome and inhibit bacterial protein synthesis…read more here…doi.org/10.1038/s41589-023-0…
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Our study on the "structural conservation of antibiotic interaction with ribosomes" is out in @nsmb. Mammoth effort led by Helge Paternoga and @caillancm reporting structures of 17 antibiotics in complex with the ribosome at 1.6-2.2Å resolution...PDF at... nature.com/articles/s41594-0…

Structural conservation of antibiotic interaction with ribosomes

Nature Structural & Molecular Biology - Here the authors present the high-resolution structures of 17 antibiotics bound to Escherichia coli ribosomes, which may inform the development of new...

nature.com
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Cool story with terrific maps! 👍🏽🎉 @BoelLab @Hashemyaser4 @InnisLab
Yaser Hashem@Hashemyaser43 Jul 2023
It's a great pleasure to share our recent work with @BoelLab who did all the heavy lifting, and @InnisLab now in @NatureComms . We describe the regulation of the macrolide resistance ABC-F translation factor MsrD, using an integrative approach. nature.com/articles/s41467-0…

Regulation of the macrolide resistance ABC-F translation factor MsrD

Nature Communications - Antibiotic resistance ABC-F factors protect the ribosome from important antibiotics. Here, for one of them, the authors describe its molecular regulation that involves...

nature.com
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encore quelques heures pour candidater ... tic tac tic tac !
martin picard@_MartinPicard14 Feb 2023
🥼🧪 JOB ALERT 🔬🦠 Nous recrutons un MCF en Microbiologie moléculaire et génétique bactérienne au @MirouxLab @IbpcF ! Recherche: Ingénierie de souches bactériennes pour l’étude structure-fonction de pompes d’efflux tripartites enseignement: microbio, génétique et métabo
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👍Dr Carine TISNE @EgmIbpc @IbpcF #womeninscienceday Women in #StructuralBiology #WomenInSTEM
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John Hunt taking us on a tour de force of CFTR structural biology and cystic fibrosis drugs... a log history, miracles of science and translational medicine and so many more things to discover in the future!
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