@InnisLab

No longer using this account. Join us at https://nitter.cf/t.co/y09AucbW14.

 Bordeaux, France
innislab.org
Joined February 2019
  • Tweets376
  • Following341
  • Followers618
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A new study by @LeroyElodie3, Thomas Perry and @ThibaudRenault shows how the antibiotic Tetracenomycin X (TcmX) blocks translation of QK motifs by sequestering peptidyl-tRNA. @ERC_Research @iecb_bordeaux @arna_lab biorxiv.org/content/10.1101/…
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Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells! biorxiv.org/cgi/content/shor…
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Ribosome meeting 2024 (Dec 2 - 4) at The institute of Medical Science, The University of Tokyo, organized by Prof Inada. @inada_lab . inada-lab.ims.u-tokyo.ac.jp/…
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Toutes nos félicitations ! 👏👏👏
Académie des sciences@AcadSciences
4 Jun 2024
🔴 EN DIRECT | Cérémonie de réception des nouveaux membres 🌿« STRUCTURE DES RIBOSOMES » Marat YUSUPOV, Directeur de recherche au @CNRS, Institut de génétique et de biologie moléculaire et cellulaire, section de #BiologieMoléculaireCellulaireGénomique 👉 youtube.com/live/ChRvAxZ8WVY
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Exciting to see peptides targeting new sites on the ribosome and exerting context-dependent effects through novel means! Congrats to all involved at @WilsonLab2 @shuramankin and @Suessmuth_Lab !!!
WilsonLab@WilsonLab2
22 May 2024
Our preprint reporting the structure and mechanism of the natural product translation inhibitors paenilamicins is out…completely novel binding site on the ribosome! dlvr.it/T7CNnf…great collaboration with ⁦@Suessmuth_Lab⁩ ⁦@shuramankin⁩
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Angiogenin controls angiogenesis (et plus) by nicking tRNAs. But it’s barely active alone. We discovered how 80S ribosome unlocks Ang’s active site and “brings in” tRNAs. Congrats to Anna Loveland and collab. w/@ajplanetearth! nature.com/articles/s41586-0…
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Read our latest #research on antimicrobial peptides that inhibit the activity of the bacterial ribosome in multiple ways, published in @NatureComms Thx to all co-authors & the members of the Grubmüller, Hoffmann and Spahn groups. rdcu.be/dHxGL nature.com/articles/s41467-0…
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Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/go…
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Innis Lab retweeted
nature
@Nature
19 Mar 2024
Researchers have used generative artificial intelligence to help them make completely new antibodies for the first time go.nature.com/3Vio70e

‘A landmark moment’: scientists use AI to design antibodies from scratch

Nature - Modified protein-design tool could make it easier to tackle challenging drug targets — but AI antibodies are still a long way from reaching the clinic.

nature.com
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Our structure of SecM-stalled ribosomes out in ⁦@natcomms⁩. rdcu.be/dBJTZ. Great work by ⁦⁦@felixgersteuer⁩ ⁦@MartinoMorici⁩ and collaborators, with data collected at the ⁦@CssbHamburg⁩ by ⁦@haaris_safdari⁩
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Not one, but two papers on arrest peptides!! What a day! 😍 Congratulations Daniel @WilsonLab2, collaborators and team! 👏👏👏
WilsonLab@WilsonLab2
19 Mar 2024
We are rapping today about arrest peptides!! Back-to-back manuscripts in ⁦@NatureComms⁩ showing how RAPP and SecM arrest peptides can stall the ribosome! SecM link here: rdcu.be/dBJTZ nature.com/articles/s41467-0…
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The final version of the most recent paper on the ribosome regulatory TnaC peptide and L-Trp saga is finally out. @gentle_heather @shuramankin Functional domains of a ribosome arresting peptide are affected by surrounding nonconserved residues - jbc.org/article/S0021-9258%2…
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Innis Lab retweeted
Jue Wang@jueseph
5 Mar 2024
I wrote a review (with @_JosephWatson @sid_thesci_kid ) on protein design using structure prediction models--i.e. hallucination, inpainting, diffusion. This approach to protein design started as a convenience but has turned out to be surprisingly powerful. cshperspectives.cshlp.org/co…
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Our work on modeling and designing biomolecular assemblies is now in @ScienceMagazine. science.org/doi/10.1126/scie… RFAA Code: github.com/baker-laboratory/… RFdiffusionAA Code: github.com/baker-laboratory/…

Generalized biomolecular modeling and design with RoseTTAFold All-Atom

Deep-learning methods have revolutionized protein structure prediction and design but are presently limited to protein-only systems. We describe RoseTTAFold All-Atom (RFAA), which combines a residu...

science.org
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We are #hiring! In collaboration with #Xavier_Guillory, we seek a talented and motivated postdoctoral researcher in #cryoEM to study membrane #kinase receptors involved in human health and diseases. Please share widely. nature.com/naturecareers/job…

Postdoctoral Position in Structural Biology (M/W) - Bordeaux (Ville), Gironde (FR)

Postdoc position in structural biology to unravel the molecular mechanisms of a receptor kinase associated with human health and diseases.

nature.com
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We reveal the mechanism of bacterial ribosome recycling by HflXr (and HflX). HflXr employs a novel strategy to split the ribosome into subunits that differs from that mediated by EF-G and RRF academic.oup.com/nar/advance…

Mechanistic insights into the alternative ribosome recycling by HflXr

Abstract. During stress conditions such as heat shock and antibiotic exposure, ribosomes stall on messenger RNAs, leading to inhibition of protein synthesi

academic.oup.com
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We are thrilled to share our last #research story @NatureSMB describing how the CNK-HYP scaffolding complex activates RAF kinase by enhancing the KSR:MEK interaction. Great collaborations with the Sicheri lab @SinaiHealth and Therrien lab @IRIC_umontreal rdcu.be/dzjYS
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Cresomycin—a novel synthetic molecule—demonstrates remarkably robust efficacy against multiple, evolutionary divergent forms of antimicrobial resistance, researchers report in Science. Read more: scim.ag/5VZ
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Congratulations Alba! First an HFSP fellowship and now an MSCA fellowship to work on cool new antiviral defense systems @MDMlab_Paris ! 🥳🍾🥂Exciting times lie ahead!!
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Congrats Matt @gagnon_lab and collaborators @chillzaa and @SergeyVMelniko1 ! Beautiful work!
Matthieu Gagnon@gagnon_lab
14 Feb 2024
We are thrilled to share our new story out @Nature - the discovery of a novel family of ribosome hibernation factors. This is the result of an exciting and stimulating collaboration between three labs @GagnonLab, @SergeyVMelniko1, and @chillzaa nature.com/articles/s41586-0…
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Bacteria have an astonishing ability to put their life on pause in the face of stress and starvation by entering a state of dormancy. Here, we discover one aspect of this remarkable self-preservation strategy: nature.com/articles/s41586-0…
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