@BiophysK

Single molecule biophysicist, Tenure track assist. prof. at the University of Groningen. Enjoys food, bouldering, silliness & science. @biophysk.bsky.social

Joined July 2017
  • Tweets609
  • Following4K
  • Followers2.2K
55Media
Single-molecule optical tweezers reveal salt dependence of the interdomain interactions in a membrane transporter OpuA in nanodiscs Congratulations to @lyanvdsleen and all the authors! @JanAdStevens @CG_Martini @BiophysK 👏@MembraneEnzymo1 @CellReports: doi.org/10.1016/j.celrep.202…
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🔬Exciting Opportunity! 🌐Join us at @kavlioxford in a mission to unravel gene expression inside the jungle of live cells! Intrigued by single molecules, RNA, condensates, AI and bacteria? Read on! 🚀Two 4-year positions. RT pls! #ScienceJobs #Postdoc #bacteria #singlemolecule🌟
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Looking for a PhD student to join my group studying bacterial virulence factors using cryo-EM, advanced biochemistry, and molecular biology. Modern environment, amazing colleagues, and a lively city in the Top of the Netherlands! Apply: rug.nl/about-ug/work-with-us…
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We are looking to establish a DNA origami synthesis core facilty @UniHeidelberg. If worked with #DNAorigami in your PhD, have experience with chemical synthesis and good organizational skills, please get in touch! RT appreciated.
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🧬 Exciting PhD Opportunity in Statistical Physics of Chromosomes! 🌐✨@VUamsterdam The @CBroedersz Broedersz group has an ERC funded opening for a four-year PhD student position on the statistical physics of chromosomes. 🔗 Read moore and apply here: workingat.vu.nl/vacancies/ph…
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Diverse topics from dynamics of tRNAs to capsid uncoating in HIV-1 and single molecule enzymology by our session speakers illustrating power of single molecule approaches! Thanks Mark Williams, Jinyi Fei and Kasia Tych for your wonderful talks #BPS2024
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I have an open PhD position. If you are looking for a biomoldeing PhD position, this is for you. candidate.hr-manager.net/App…

PhD fellowship in Computational Biophysics

candidate.hr-manager.net
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Check out our latest preprint to see how we used #MassPhotometry to investigate the mechanisms of enzyme diffusion: biorxiv.org/content/10.1101/… Spoiler alert: there are some interesting oligomerisation dynamics going on @sanigulk @BiophysK @fraaije1

Investigating the mechanisms of enzyme diffusion using mass photometry

The existence of the phenomenon of enhanced enzyme diffusion (EED) has been a topic of debate in recent literature. The majority of experiments confirming the existence of this phenomenon have been...

biorxiv.org
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In December the advisory committee physics of life circulated its latest newsletter, with info on our meetings, the committee itself, grant awardees and biosketches by @AgChaigne @cees_dekker Do you want to be profiled by @BiophysK and NWO? Contact us! nwobiophysics.nl/newsletters
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#OPENACCESS: Fascinating findings on the critical role of binding stoichiometry in Aha1-Hsp90 interaction. It's incredible how the interaction's stoichiometry can exert varied impacts on ATPase rate, conformational kinetics, and protein stability. ow.ly/u6WT50PHSEi

Aha1 regulates Hsp90’s conformation and function in a stoichiometry-dependent way

The heat shock protein 90 (Hsp90) is a molecular chaperone, which plays a key role in eukaryotic protein homeostasis. Co-chaperones assist Hsp90 in client maturation and in regulating essential...

cell.com
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Kasia Tych retweeted
LUMICKS
@LUMICKS_nl15 Aug 2023
How do co-chaperones regulate heat shock protein activity and thus ensure proper folding of a large variety of proteins? C-Trap and single-molecule FRET data from @BiophysK and @HugelLab deliver an answer! Now published in @BiophysJ bit.ly/3ODxEtX
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Check out our new manuscript on the mechanism of Hsp90 and Aha1 cochaperone interaction using #smFRET and #opticaltweezer. An interesting project! @HugelLab @BiophysK @molenuel @lni2_ipi @LauraSilberman1
Kasia Tych@BiophysK14 Aug 2023
Happy that our article, in collaboration with the @HugelLab, about how the co-chaperone Aha1 interacts with the molecular chaperone Hsp90 is out! authors.elsevier.com/sd/arti… Congratulations to @LauraSilberman1 and the other authors! Also to @AnaRa022 for her first journal cover!
Schematic illustration of Hsp90 and its co-chaperone Aha1 in complex, tethered between two optically trapped beads in an optical tweezers setup.

ALT Schematic illustration of Hsp90 and its co-chaperone Aha1 in complex, tethered between two optically trapped beads in an optical tweezers setup.

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From the structural biology side of the group, Marco @MarcovdNoort with @DrougkasP @CPaulino_ and Bert posted on a new study on transient domain interaction in the c-di-AMP regulated ABC transpoter OpuA BioRxiv biorxiv.org/cgi/content/shor……
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Also from Michele @MichelePartipi3, together with Nico Claassens @NicoC_MicSynBio from @BaSyCresearch a review on how to supply reducing power to synthetic cell-like systems. We did not quite agree on the title… pubs.acs.org/doi/10.1021/acs…
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From the synthetic biology side: Eleonora, Michele @MichelePartipi3, Jelmer (from @BaSyCresearch ), Douwe reviewed metabolic modules for building a synthetic cell in bottom-up; and methodological aspects of reconstitution of membrane proteins pubs.acs.org/doi/10.1021/acs…
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We have a new pore! Check out the properties of 15 nm di-dodecameric YaxAB pubs.acs.org/doi/10.1021/acs… Credit to Sabine for bringing this work to light!

Protein Sizing with 15 nm Conical Biological Nanopore YaxAB

Abstract. Nanopores are promising single-molecule tools for the electrical identification and sequencing of biomolecules. However, the characterization of

pubs.acs.org
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EMBO/FEBS Susan Lindquist School on Proteostasis meetings.embo.org/event/23-p… 📣Deadline approaching! -top speakers from across the #proteostasis field -only for PhD students and postdocs (60 total)

Susan Lindquist School on Proteostasis

Cells constantly surveil and monitor their proteome to ensure proper function. These processes, spanning multiple steps from protein synthesis to folding and degradation, are summarized as proteostas…

meetings.embo.org
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Kasia Tych retweeted
Guardian news
@guardiannews4 Jun 2023
Poland: hundreds of thousands march against rightwing populist government dlvr.it/Sq7kW2

Poland: hundreds of thousands march against rightwing populist government

‘We’re half a million here,’ says Donald Tusk at what he says is biggest political gathering since Poland regained independence

theguardian.com
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FLEXR uses Ringer-based electron-density sampling to build explicit multi-conformer models for refinement, capturing conformations in ligand-binding sites that were undetected using other methods. #CrystallographicRefinement #ModelBuilding doi.org/10.1107/S20597983230…
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A PhD and a postdoc positions are available in my group (multiscale modelling of membranes). NBI/University of Copenhagen/Denmark jobportal.ku.dk/phd/?show=15… jobportal.ku.dk/videnskabeli…
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