@BettsLab

Human Immunology Lab at UPenn.

 Philadelphia, PA
bettslab.org
Joined July 2018
  • Tweets59
  • Following37
  • Followers561
9Media
Congratulations to @carlhjune (@PennPathLabMed), @kkariko (@PennNSG) & @WeissmanLab (@PennMedicine) on being named to the @Forbes list of top 250 living innovators! tinyurl.com/34mxafsk
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A new #mRNA-LNP approach can target and reprogram cytotoxic effector T cells in vivo in preclinical models, highlighting the potential for future treatments against infection, cancer, and autoimmunity. @angelarcorrigan @BettsLab @WeissmanLab scim.ag/3Rn2WtM
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karen@karenwong101313 Mar 2024
hello i published this paper today proud of this one - it truly turned out cooler than even the most optimistic version of myself thought it would when the project started also i'm defending in 2 days so if you don't feel like reading just come hear me tell you about it! 🙂
Jon Epstein Lab@JonEpsteinLab13 Mar 2024
New paper out of the lab today from @karenwong1013 - we show that a subset of growth factor-responsive gene activation requires the nuclear kinase MSK2, which phosphorylates H3K9me2S10 at enhancers of these responsive genes prior to their transcription. science.org/doi/10.1126/scia…

Growth factor–induced activation of MSK2 leads to phosphorylation of H3K9me2S10 and corresponding...

MSK2 kinase is activated by growth factor signaling to phosphorylate histones at enhancers of growth factor–responsive genes.

science.org
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Thrilled to unveil our review on "Human circulating and tissue-resident memory CD8+ T cells," published in @NatImmunol. nature.com/articles/s41590-0…

Human circulating and tissue-resident memory CD8+ T cells

Nature Immunology - Buggert and colleagues provide a broad picture in this review of circulating and tissue-resident memory CD8+ T cells, which are ultimately responsible for effective immune...

nature.com
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Vincent Wu@vincewu97 Jul 2022
Come see what I’ve been up to these past few years! DM for Zoom link :)
CAMB Graduate Group@CAMBUpenn7 Jul 2022
Vincent Wu @vincewu9 from the Betts lab @BettsLab defends tomorrow!!
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New work from us. Identification of functional resident memory CD8+ T cells against SARS-CoV-2 in tonsils collected prior to the pandemic. The same type of responses are not found in blood. Location matters! science.org/doi/10.1126/scii…
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Very excited that our paper on pre-existing cross-reactive SARS-CoV-2 antibodies is out now in @CellCellPress! Here is an excellent summary of our findings by @SCOTTeHENSLEY. Grateful for being able to do team science during a pandemic @PennMedicine
Hensley Lab@SCOTTeHENSLEY9 Feb 2021
1/ Our paper showing that ~20% of humans possessed non-neutralizing antibodies against SARS-CoV-2 prior to the COVID-19 pandemic was published today @CellCellPress. cell.com/cell/fulltext/S0092…
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Pleased to share our co-authored report that resulted from a collaboration between nPOD (UF) and HPAP (UPenn) contradicting the original findings by Hamad et al. TCR /BCR dual-expressing cells and their associated public BCR clonot... sciencedirect.com/science/ar…
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Betts Lab retweeted
Cell@CellCellPress29 Dec 2020
Out now! A core signature that defines #human #tissue-emigrant CD8+ #Tcells under homeostatic conditions. bit.ly/3rCMgx9 @marcus_buggert @karolinskainst
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Betts Lab retweeted
Dr. Sunny Shin@SunnyShinLab3 Aug 2020
For anyone applying to grad school & interested in microbiology or host:microbe interactions, please join for a virtual discussion this Wed Aug 5 to learn more about our @CAMBUpenn Microbiology, Virology, & Parasitology PhD program & meet some of our amazing students & faculty!
Dr. Arnaldo Díaz@ADiaz_PhD31 Jul 2020
🚨 Join #Microbiology, #Virology, & #Parasitology faculty, alumni, & PhD trainees on Aug 5, for a panel discussion on the research, mentoring, resources, & community that @CAMBUpenn has to offer & why MVP is the ideal prog for your #PhD. Register: bit.ly/2ZPSXjD
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Great article in the NYT from Gina Kolata. Nice analysis of what we know about immune heterogeneity and how it might relate to treatments How the Coronavirus Short-Circuits the Immune System - The New York Times nytimes.com/2020/06/26/healt…

How the Coronavirus Short-Circuits the Immune System (Published 2020)

In a disturbing parallel to H.I.V., the coronavirus can cause a depletion of important immune cells, recent studies found.

nytimes.com
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Immunology of severe #Covid_19. Several innate and adaptive leukocytes are affected! Preprint from @BettsLab.
bioRxiv Immunology@biorxiv_immuno19 May 2020
Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection biorxiv.org/cgi/content/shor… #biorxiv_immuno
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As 2018 comes to a close, we have had so many wonderful covers in @SciImmunology this year. Several labs including @VirusesImmunity @BettsLab @PittetLab @CellReproLab and @Regeneron have contributed these images. Thank you!
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Monkeys ≠ Humans. An antibody that helped "cure" monkeys infected with AIDS virus and triggered much interest did zilch for HIV-infected humans. sciencemag.org/news/2018/07/…
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Replying to @BettsLab
@BettsLab at UPenn now has a Twitter account! Follow them! #immunology #HIV #Tcells
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Check out this exciting paper from the Betts lab: tissue-resident T-cells cells are key for HIV replication. immunology.sciencemag.org/co…
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