@BettsLab

Human Immunology Lab at UPenn.

 Philadelphia, PA
bettslab.org
Joined July 2018
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  • Followers561
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Congratulations to @carlhjune (@PennPathLabMed), @kkariko (@PennNSG) & @WeissmanLab (@PennMedicine) on being named to the @Forbes list of top 250 living innovators! tinyurl.com/34mxafsk
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A new #mRNA-LNP approach can target and reprogram cytotoxic effector T cells in vivo in preclinical models, highlighting the potential for future treatments against infection, cancer, and autoimmunity. @angelarcorrigan @BettsLab @WeissmanLab scim.ag/3Rn2WtM
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link.growkudos.com/1f8rzz4o1…

Lymph node CD8+ T cells cannot effectively prevent HIV rebound after therapy interruption

We tested whether CD8+ T cells trapped in lymph nodes of SIV infected rhesus macaques during antiretroviral therapy interruption were able to prevent reactivation of viral replication and prevent...

growkudos.com
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Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset biorxiv.org/content/10.1101/…

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset

Autoimmune destruction of pancreatic β cells results in type 1 diabetes (T1D), with pancreatic immune infiltrate representing a key feature in this process. Studies of human T1D immunobiology have...

biorxiv.org
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Thrilled to unveil our review on "Human circulating and tissue-resident memory CD8+ T cells," published in @NatImmunol. nature.com/articles/s41590-0…

Human circulating and tissue-resident memory CD8+ T cells

Nature Immunology - Buggert and colleagues provide a broad picture in this review of circulating and tissue-resident memory CD8+ T cells, which are ultimately responsible for effective immune...

nature.com
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Announcing an available postdoctoral position, focusing on bioinformatic analysis in the context of human viral infection and autoimmunity! Please contact us at bettslab.org or apply to the following posting: med.upenn.edu/apps/my/bpp_po…
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Our latest paper just published @NatImmunol: First single cell ATACseq-based definition of HIV reservoirs ex vivo! nature.com/articles/s41590-0… Congratulations to Vincent Wu @vincewu9 and Laura Vella @LauraVella17

Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4+ T cell reservoir

Nature Immunology - Betts and colleagues have developed a method for characterizing the HIV reservoir at the single-cell level to gain insight into the heterogeneous nature of CD4+ T cells...

nature.com
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Betts Lab retweeted
Vincent Wu@vincewu97 Jul 2022
Come see what I’ve been up to these past few years! DM for Zoom link :)
CAMB Graduate Group@CAMBUpenn7 Jul 2022
Vincent Wu @vincewu9 from the Betts lab @BettsLab defends tomorrow!!
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Extensive heterogeneity of the HIV-1 infected CD4+ T-cell reservoir revealed by single-cell viral ASAPseq biorxiv.org/content/10.1101/…

Extensive heterogeneity of the HIV-1 infected CD4+ T-cell reservoir revealed by single-cell viral...

Defining the long-lived HIV reservoir during antiretroviral therapy remains a challenge for HIV cure research. To determine if unifying cell surface or genomic features can be identified in unpertu...

biorxiv.org
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New work from us. Identification of functional resident memory CD8+ T cells against SARS-CoV-2 in tonsils collected prior to the pandemic. The same type of responses are not found in blood. Location matters! science.org/doi/10.1126/scii…
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I came so close to being famous last week! I am the “Doc” he referred to in the audience during his speech. I speak, I get heckled. He speaks next and gets in Newsweek. Maybe next time I will wear my Gritty costume. newsweek.com/dad-school-boar…

'What Hitler Wants': Dad Turns up to School Board Meeting in Hazmat Suit

Scott Brady, who runs a painting business, told attendees: "This is what you wear in an outbreak."

newsweek.com
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More great work from the Penn COVID research team! Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19 immunology.sciencemag.org/co…
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Very excited that our paper on pre-existing cross-reactive SARS-CoV-2 antibodies is out now in @CellCellPress! Here is an excellent summary of our findings by @SCOTTeHENSLEY. Grateful for being able to do team science during a pandemic @PennMedicine
Hensley Lab@SCOTTeHENSLEY9 Feb 2021
1/ Our paper showing that ~20% of humans possessed non-neutralizing antibodies against SARS-CoV-2 prior to the COVID-19 pandemic was published today @CellCellPress. cell.com/cell/fulltext/S0092…
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Replying to @BettsLab @Hamad_JHU_Lab @Bruskolab @HamadlabH
Finally in reply to the two questions about Figure 2A and 2C: these are just representative analyses of data from Penn vs. UFDI. They are NOT the same donors between sites, hence the differences in frequency. The data in 2B and 2D is what is important for comparison
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Replying to @BettsLab @Hamad_JHU_Lab @Bruskolab @HamadlabH
I stand by our team and their findings and we will provide our data for analysis by the scientific community for their own judgement. Reproducibility is critical, and in the case we could not confirm DE cells as a biomarker of T1D, or clone X as a public clone.
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Replying to @Hamad_JHU_Lab @Bruskolab
It is clear that @HamadlabH disagrees with our article attempting to replicate key findings of their original paper. I invite readers to read both papers and the reply and make their own judgements. It is however inappropriate to accuse us of misconduct in our analysis.
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Pleased to share our co-authored report that resulted from a collaboration between nPOD (UF) and HPAP (UPenn) contradicting the original findings by Hamad et al. TCR /BCR dual-expressing cells and their associated public BCR clonot... sciencedirect.com/science/ar…
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Replying to @IF91 @albertojapp @CellCellPress
Julie's paper is now published in Cytometry: doi.org/10.1002/cyto.a.24027 And yes, she showed many of these cells are just complexes
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After a year in review at Cell, finally have this published! Congrats Alberto! TCR /BCR dual-expressing cells and their associated public BCR clonot... sciencedirect.com/science/ar…
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Betts Lab retweeted
Cell@CellCellPress29 Dec 2020
Out now! A core signature that defines #human #tissue-emigrant CD8+ #Tcells under homeostatic conditions. bit.ly/3rCMgx9 @marcus_buggert @karolinskainst
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