@JonEpsteinLab

News from Jonathan A. Epstein's lab at the University of Pennsylvania @PennMedicine. Tweets by lab members. https://xitter.cf/t.co/3F9KxDofVi

 Philadelphia, PA
Joined September 2019
  • Tweets151
  • Following351
  • Followers1.4K
25Media
Jon Epstein Lab retweeted
karen@karenwong101319 Mar 2024
still don’t think I’ve fully processed the last few days but i got a PhD, isn’t that wild so much gratitude in my heart for everyone who has been a part of the ride, and esp @jonepstein1 who shaped me into the scientist that i am today and for many years of mentorship and care
CAMB Graduate Group@CAMBUpenn14 Mar 2024
Karen Wong @karenwong1013 from the Epstein lab @JonEpsteinLab @jonepstein1 defends tomorrow!
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New paper out of the lab today from @karenwong1013 - we show that a subset of growth factor-responsive gene activation requires the nuclear kinase MSK2, which phosphorylates H3K9me2S10 at enhancers of these responsive genes prior to their transcription. science.org/doi/10.1126/scia…

Growth factor–induced activation of MSK2 leads to phosphorylation of H3K9me2S10 and corresponding...

MSK2 kinase is activated by growth factor signaling to phosphorylate histones at enhancers of growth factor–responsive genes.

science.org
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And, @karenwong1013 defends on Friday! @CAMBUpenn @pennbgs
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Jon Epstein Lab retweeted
Penn Medicine CSO@PennMedCSO8 Aug 2023
Congratulations to Faith Karanja (@JonEpsteinLab/ @PennCDB) & Jeffrey Rosa (@KayserLab/ @PennPsych) on being named 2023 @LSRFdtn early-career postdoctoral researcher awardees!🎉 @PennBPP t.ly/xqU3X
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Graduate student @DevBioAcademic defends his thesis 3 weeks from today! Contact him for the zoom link if you'd like to attend remotely. @CAMBUpenn
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Jon Epstein Lab retweeted
PennCVI@PennCVI25 Oct 2022
Great talk by Dr. Jon Epstein on In Vivo CAR T Cells for Cardiac Fibrosis during Day 2 of the Symposium! @StanfordCVI @PennMedEVDCSO @jonepstein1
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Jon Epstein Lab retweeted
Sean M Wu, MD PhD@SeanM_Wu25 Oct 2022
Winners of Poster Award Competition @PennCVI @stanfordcvi symposium from @Prosser_Lab @jonepstein1 and @MarguliesLab . Congratulations!!
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Jon Epstein Lab retweeted
Margulies Lab@MarguliesLab25 Oct 2022
Last session of the @PennCVI / @StanfordCVI symposium starting with @jonepstein1 @JonEpsteinLab
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Replying to @AimeeJuan3
@aimeejuan3 epic thesis work is out--a new developmentally unveiled and allele-specific CTCF insulator & DMR regulates imprinted expression of Grb10 and Ddc isoforms in mesoderm. TY collaborators @JonEpsteinLab @DevBioAcademic authors.elsevier.com/a/1flS9…
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Hey Everyone! The ModzLab has room for one more PostDoc! We have a few exciting projects that look at Retrotransposons in Development and Disease, with a bit of CRISPR sprinkled here and there. Please Re-Tweet! Post Doctoral Researcher jobs.sciencecareers.org/job/…

Post Doctoral Researcher - Philadelphia

Post Doctoral Researcher The Modzelewski Lab (TheModzLab) at the University of Pennsylvania Department of Biomedical Sciences School of Veterinary M

jobs.sciencecareers.org
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We continue to explore how heterochromatin is organized at the nuclear periphery! Check out our new exciting work available on @biorxivpreprint. PRR14 organizes H3K9me3-modifed heterochromatin at the nuclear lamina biorxiv.org/content/10.1101/…

PRR14 organizes H3K9me3-modifed heterochromatin at the nuclear lamina

The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located...

biorxiv.org
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Jon Epstein Lab retweeted
Hannah Billig@Hannah_Billig_24 Apr 2022
#sciencesunday Fighting cardiac fibrosis🔥🫀@DevBioAcademic and colleagues used mRNA containing lipid nanoparticles to generate CAR T cells in vivo, reducing fibrosis & restoring cardiac function. Published in @ScienceMagazine @JonEpsteinLab @YoungDgk science.org/doi/10.1126/scie…

CAR T cells produced in vivo to treat cardiac injury

In vivo generation of CAR T cells by delivery of modified mRNA improves recovery in a mouse model of heart failure.

science.org
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Today we celebrate Ricardo Linares-Saldana from the Epstein @JonEpsteinLab @jonepstein1 and Jain labs #BGSgraduation2022 1/9
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Congrats to our rockstar postbac @PedroOMndezFer1 who was accepted into Penn's MD/PhD program this week, celebrating with tahini shakes from Goldie! We are soooo proud of you!!
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Jon Epstein Lab retweeted
Ron Vagnozzi@VagnozziRJ3 Mar 2022
Merging RNA technology and #cardioimmunology to tackle heart fibrosis - some thoughts from @McKinseyLab and us on this exciting new approach by @JonEpsteinLab & colleagues. Check out the full paper at science.org/doi/10.1126/scie… #CardioTwitter

CAR T cells produced in vivo to treat cardiac injury

In vivo generation of CAR T cells by delivery of modified mRNA improves recovery in a mouse model of heart failure.

science.org
Cell Stem Cell@CellStemCell3 Mar 2022
Preview in this issue of CellStemCell: T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR cell.com/cell-stem-cell/full…

T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR

Fibrosis, or chronic fibroblast activation and extracellular matrix deposition, underlies most cardiovascular diseases and remains challenging to target therapeutically. Reported in Science by Rurik...

cell.com
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“CAR-based therapies: opportunities for immuno-medicine beyond cancer” Haig Aghajanian (@Haig_A), Joel Rurik (@DevBioAcademic) and @JonEpsteinLab offer their perspective on this rapidly growing area: nature.com/articles/s42255-0…

CAR-based therapies: opportunities for immuno-medicine beyond cancer

Nature Metabolism - This Perspective summarizes the ongoing development of CAR-based therapies in indications beyond cancer, including for cardiometabolic diseases, fibrosis, autoimmune diseases...

nature.com
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Our lab (and BGS/CAMB) is full of great people! @JonEpsteinLab is interested broadly in heart development. Much of our lab (including fellow DSRB student, friend, & excellent human @karenwong1013) studies how gene programs are epigenetically regulated at the nuclear periphery.
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Good morning! I’m Joel Rurik (@DevBioAcademic) delighted to do the first CAMB twitter takeover of 2022! As a 4th yr DSRB PhD candidate in @JonEpsteinLab, I study the injured heart and develop exciting mRNA-based immuno-medicine therapies.
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In this week's @ScienceMagazine cover story, @DevBioAcademic, @Haig_Ag, @WeissmanLab, Parhiz, @JonEpsteinLab, & al. use CD5-targeted lipid #nanoparticles to generate therapeutic #CARTcells in vivo! bit.ly/Sci_abm0594 w/ PS by Gao & Chen: bit.ly/Sci_abn0851
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Jon Epstein Lab retweeted
Eric Topol
@EricTopol7 Jan 2022
You may have missed this exciting report @ScienceMagazine for the potential of mRNA/nanoparticle -> engineer T cells to treat cardiac injury, heart failure and other fibrotic disorders science.org/doi/10.1126/scie… @JonEpsteinLab @ScienceVisuals @cbickel27
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