@LammingLab
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All views solely of Dr. Lamming and do not necessarily reflect views of my employers, funders, or societies. Retweet≠Endorsement. @LammingLab@fediscience.org
Wisconsin, USA
Joined April 2015
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Lamming Lab retweeted
Why do muscle fibres shrink with age?
Not because myofibrils get smaller — because there are fewer of them.
We followed this from whole-muscle down to individual myofibrils, in humans and mice, across ageing and disuse.
Tweetorial below
Open Access here: physoc.onlinelibrary.wiley.c…
1/ Why do muscles atrophy with aging and disuse?
Is it because each tiny little myofibril gets smaller… or is it because we lose myofibrils?
In our new study, we addressed this in humans and mice. biorxiv.org/cgi/content/shor…
Full breakdown of the findings in this thread 👇
Check out the latest pre-print from our lab, the work of star graduate student @mmsonsalla! If you (a mouse who is extremely online) reduces dietary protein and increase dietary carbohydrates, does it matter what type of carbohydrates you are eating? Find out from our paper:
For those who are wondering about the human relevance of our BCAA work, a new paper showing dietary BCAAs are associated with plasma BCAAs and plasma BCAAs are associated with multiple Cardiometabolic risk factors
What an exciting story!
Excited to share our new study, spearheaded by talented former graduate student Kübra B. Akkaya-Colak!
Stearoyl-CoA desaturases regulate intestinal stem and progenitor cell metabolism and function in response to nutrient abundance: Cell Reports cell.com/cell-reports/fullte…
Lamming Lab retweeted
Excited to share our new study, spearheaded by talented former graduate student Kübra B. Akkaya-Colak!
Stearoyl-CoA desaturases regulate intestinal stem and progenitor cell metabolism and function in response to nutrient abundance: Cell Reports cell.com/cell-reports/fullte…
Lamming Lab retweeted
Profound and heartfelt thanks to the over 100 contributors who made this epic 3-volume, >1600 pages landmark academic treatment of aging biology, longevity therapeutics, and the science, technology, and policy of life extension possible, including @NirBarzilaiMD, @sjayolshansky, @biogerontology, @davidasinclair, @j_n_justice, @RaianyRomanni, @drmichaellevin, @ydeigin, @aubreydegrey, @TinaWoods, @JamesPeyer, @Danbelsky, @Dr_Bischof, @LidskyPeter, @MarkHamalainen, @DToddWhite, @marcpbernegger, @MattYousefzadeh, @M_S_Ringel, @LeeYuta45307, @HeWei16027, @DrGlorioso, @AnmolMD, @adamgries, @gblander1, @ProfValterLongo, @LammingLab, @DomiWilczok, @LPiolopez, @pgerwill, @KarlPfleger, @BernardSiegel, @Yu_Xuan_Lu, @Rcmsiow, @cordeiro, @Scinquisitor, @TinkingGumbel, @romanbauer111, @KeithComito, @soniaarrison, and many more.
Special thanks to my fellow Co-Editors, @MaxRangeley, Regina Monaco, and David Wood (@dw2), whose intellectual leadership, editorial rigor, and sustained commitment helped transform an ambitious vision into a coherent three-volume landmark work. It was a privilege to shape this project alongside them.👨⚕️
Another great discussion of protein in Scientific American @sciam scientificamerican.com/artic… - with a mention of @mariahcalubag recent valine restriction paper as well!
Great discussion of dietary protein and aging in @ScienceNews today "The protein craze may not be for everyone", spurred in part by @baileyknopf 's new review article entitled "The hallmarks of protein and amino acid restriction in aging and longevity"
Great discussion of dietary protein and aging in @ScienceNews today "The protein craze may not be for everyone", spurred in part by @baileyknopf 's new review article entitled "The hallmarks of protein and amino acid restriction in aging and longevity"
Here's a direct link to the open access review in @cellpressblue cell.com/cell-press-blue/ful…
Lamming Lab retweeted
Branched chain aminos (e.g. leucine & valine) help build muscle but also activate mTOR. Here, Lamming & team report that restricting valine extends the lifespan of male mice 23%, indicating high protein diets deserve scrutiny from a longevity perspective 🐭
I am delighted to be able to share the latest study from the @LammingLab, “Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice” led by former graduate student @mariahcalubag!
Lamming Lab retweeted
Valine restriction improves metabolic health in mice, promotes leanness and glycemic control across ages, and reduces frailty, cancer prevalence and senescent cell burden in both sexes while increasing median male lifespan by 23%.
By @LammingLab et al. #DR
nature.com/articles/s43587-0…
Lamming Lab retweeted
I am delighted to be able to share the latest study from the @LammingLab, “Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice” led by former graduate student @mariahcalubag!
🤖 Made with AI
I am delighted to be able to share the latest study from the @LammingLab, “Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice” led by former graduate student @mariahcalubag!
🤖 Made with AI
We thank all of our great collaborators within and outside the lab, including @garacreen (who now has her own lab at U. Bath), @RNMarshallPhD, @mmsonsalla @iCCup_Spec @baileyknopf @ShoshanaYakar @drteresaliu @AttieLab and @sadagurski
Finally, we would like to thank the reviewers and the editorial team @NatureAging