@BVincentv

Post-doc at NKI

 Amsterdam, The Netherlands
Joined August 2018
  • Tweets26
  • Following403
  • Followers47
#posting this again if any #postdoc candidates are interested in digging deep into #TCR #Crossreactivity #Tcell functional studies in #autoimmunity and #cancer -please contact me!
Saligrama lab_WUSTL@SaligramaLab12 Jun 2025
Anticipating #new #funding -our lab is seeking #postdocs with #expertise in #Tcells #TCRs #crossreactivity #molecularbiology #protein #production Please #email #RT -start date flexible, end of #2025 or beginning of #2026
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Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side effect: nature.com/articles/s41586-0…. Work led by Jia-Cheng Liu, Donpgeng Wang, Elsa Callen and many terrific collaborators!

Mechanism of cytarabine-induced neurotoxicity

Nature - Certain antimetabolites used to treat cancer are more neurotoxic than others, and it is now shown that this is due to their greater tendency to generate DNA double-stranded breaks, whereas...

nature.com
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Happy to share this concise review and outlook for single-cell sequencing methods to unravel cell biology of the nucleus! Big shoutout to my friend and former colleague Peter Zeller for sharing the work! sciencedirect.com/science/ar…
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Acute multi-level response to defective de novo chromatin assembly in S-phase (Dreyer et al., 2024) cell.com/molecular-cell/full…
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Online Now: Acute multi-level response to defective de novo chromatin assembly in S-phase dlvr.it/TG85ld
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Researchers from the Mattiroli group discovered that DNA packaging in cells can directly impact the speed of DNA copying during cell division. The packaging sends signals through an unusual pathway, affecting the cell’s ability to divide and grow. More: hubrecht.eu/dna-packaging-di…
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Ready to establish your own research group at the Hubrecht Institute for molecular and developmental biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! hubrecht.eu/job/tenure-track…
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How does genomic mosaicism arise during development? We identified that embryo patterning signals not only readour genetic blueprints to build organisms, but they also play a critical role in their maintenance. A quick dive into our new paper nature.com/articles/s41467-0… 1/10
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Ever wondered how stem cells ensure a balance between cell fates in the gut?⚖️Turns out, they’ve got rhythm!🎶Our latest research reveals that NOTCH-driven oscillations regulate stem/progenitor cell abundance and specify secretory subtypes. Check it out: biorxiv.org/content/10.1101/…
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One week left to apply, please get in touch if you want to learn more about the role and our teams. Sharing with your network is much appreciated!
Ahmed Mahfouz@ahmedElkoussy4 Jul 2024
Come and join us! Lots of cool psatial data and interesting questions to drive our knowledge on duchenne therapies
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A high-resolution view of how replication-coupled DNA breaks are generated, processed and repaired. Congrats to @pavani_raphael, @TripathiVeenu, and many terrific collaborators including @FrogWalterLab, @CejkaLab, @weiwsmiling. See science.org/doi/epdf/10.1126…
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scEdU-seq offers a tool to detect nascent, newly synthesized, DNA in single cells, enabling the study of replication fork speed in human cells. nature.com/articles/s41592-0… @jervdberg @AlexandervanOu1 @BVincentv @acebron @Anchel_91 @marcelvanvugt @RBTjeerdsma
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New scEdU-seq method developed by @AlexandervanOu1 group measures DNAreplication speed in individual cells & may provide new insights into DNAreplication, embryonic development & cancer. hubrecht.eu/method-dna-repli… @jervdberg @BVincentv @Acebron @Anchel_91 @marcelvanvugt @RBTjeerdsma
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Hes genes are dynamically expressed in many tissues. But how do dynamics differ between tissues and are they always oscillatory? We have addressed this question in the context of the developing embryo, where somites and neural tube form side-by-side. biorxiv.org/content/10.1101/…

Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell...

The intricate dynamics of Hes expression across diverse cell types in the developing vertebrate embryonic tail have remained elusive. To address this, we developed an endogenously tagged Hes1-Achil...

biorxiv.org
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What happens when cells stop assemblying nucleosomes during DNA replication? We used CAF-1-degron human cells to answer this question, and look at the immediate effects within a single cell cycle. 🧵⬇️ biorxiv.org/content/10.1101/… – at Utrecht, The Netherlands

Acute multi-level response to defective de novo chromatin assembly in S-phase

Long-term perturbation of de novo chromatin assembly during DNA replication has profound effects on epigenome maintenance and cell fate. The early mechanistic origin of these defects is unknown....

biorxiv.org
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Really enjoyed working on this and happy to be part of the team!
Jeroen van den Berg@jervdberg16 Dec 2022
Exhilarated to share our pre-print describing a novel method, scEdU-seq, to measure DNA replication forks and their speeds in singe cells. Many thanks to @AlexandervanOu1, @Bvincentv and others @_Hubrecht for making it happen! biorxiv.org/content/10.1101/…

Acceleration of genome replication uncovered by single-cell nascent DNA sequencing

In a human cell thousands of replication forks simultaneously coordinate the duplication of the entire genome. The rate at which this process occurs, might depend on the epigenetic state of the...

biorxiv.org
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It was a lot of fun presenting at the #SCG2022 meeting! A lot of inspiration and novel concepts to integrate! @AlexandervanOu1 @BVincentv @AmirGiladi @souf_mourra @ckoyunlar @mvanins @vivekbhr @Marloes_3105
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A summary of my own views on the challenge to characterize the Waddington landscape of cell differentiation: europhysicsnews.org/articles…
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Our study “Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids” is out! nature.com/articles/s41586-0… hubrecht.eu/scientists-devel… @Nature @_Hubrecht @Cambridge_Uni @annionna, @BVincentv @Marloes_3015 @nmoris, @PeterBeej @AMartinezArias A summary: (1/10)
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