Wow! This is our IL-6 domain-swapped dimer structure from a recently published paper. Tweet coming soon.
Crystal structure of the Fab fragment of the anti-IL-6 antibody I9H in complex with a domain-swapped IL-6 dimer (PDB code: 8YWQ) #molecularart #scivis @proteinimaging @dzine_ai
behance.net/gallery/21365825…
This is a huge amount of data on human transporters! It will take me a while to find something potentially useful for our lab :)
Are you curious what is known about SLCs? And how they are related? We are enthusiastic to wrap up the series of four (4) manuscripts by presenting the data- and knowledge-derived functional landscape of human solute carriers #SLC : biorxiv.org/content/10.1101/…
Great professors, great city. I highly recommend paying attention
Various PhD/post-doc positions available to work on synthetic cells, including purely computational projects in our group ! nature.com/naturecareers/job…
🦠🦠🦠Our article about homodimeric luciferase is finally out!
Our new luciferase paper is now out! Luminescence is weak, and the organism (Enhygromyxa salina) was not known to be luminescent. Reviewers were very helpful to get everything right.
Congratulations to @Aynya5 (now in Groningen) and all coauthors!
onlinelibrary.wiley.com/doi/…
Anna Yudenko retweeted
We celebrate first first-author paper by @pricelesska🥳
Using super-resolution #PALM🔬, we showed that ChR2, protein used to control neuronal activity with light in lab and clinics, forms stable (WT) or transient (mutant) dimers in human cell membranes
doi.org/10.1002/anie.2023075…
Anna Yudenko retweeted
New thrilling preprint from our team!
🔸SMLM / qPALM🔬
🔸optogenetic tool, ChR2🧬🌟
🔸ChR2 dimers in the plasma membrane🔗🔒
🔸 monomerized ChR2 mutant🔗💥
🔸Kd for dimerization in cells
First first-author preprint for a science-hero @pricelesska!👏🥳
doi.org/10.1101/2023.05.24.5…
Our new preprint about a homodimeric 🧚♀️🧚♀️ luciferase. Usually bacterial luciferases are heterodimers 🧚♀️🧚 LuxA/LuxB.
luxA gene from Enhygromyxa salina encodes a functional homodimeric luciferase biorxiv.org/cgi/content/shor… #bioRxiv
Anna Yudenko retweeted
Now accepted & published @jbiolchem ! doi.org/10.1016/j.jbc.2023.1… All spectral data is included in the Supporting Information.
New preprint from the lab: fine spectral tuning of flavin-binding fluorescent protein. Animation by Andrey Nikolaev, the leading author. biorxiv.org/content/10.1101/…
Mutagenesis of #FbFP #LOV domain:
🟠 22 variants with 486-512 nm emission maxima
🟠 three-channel imaging via spectral unmixing
🟠 two-channel fluorescence lifetime unmixing
doi.org/10.1101/2022.12.09.5…
Congratulations, @ivangushchin, @Aynya5, and all the authors!
@FPbase
Anna Yudenko retweeted
Happy to share the Methods in Molecular Biology issue on Fluorescent Proteins 🌈🎉😀. Including many “much awaited” protocols on and about Fluorescent Proteins/applications. A big THANKS to authors across the globe for contributing. 👏🏻💐
link.springer.com/book/10.10…
Anna Yudenko retweeted
Our short communication about Chloroflexus islandicus LOV is now published in BBRC 🎉 🥳 doi.org/10.1016/j.bbrc.2021.…
Great team work from Ivan, Anastasia and everybody else!
Anna Yudenko retweeted
Another day, another LOV domain color tuning paper 🥳 Red-shifted variants for two color imaging. Open access @jbiolchem jbc.org/article/S0021-9258(2… Great collaboration with IMET/IBG-1/IBI-1/7 @fz_juelich, and also @RWTH!
Anna Yudenko retweeted
Now published in Proteins: Structure, Function, and Bioinformatics, access link: onlinelibrary.wiley.com/shar…
Congratulations to Vera, Alina, @kirkovalev94, Ivan, @Aynya5, @AstashkinR, Valentin and me🥳
Color tuning of LOV domains isn't easy, but we have some ideas in the pipeline!
And one more: high-resolution structures of potentially color-shifted LOV mutants, although the shifts turned out to be very moderate
biorxiv.org/content/10.1101/…
«Государственная Дума РФ: Против поправок о просветительской деятельности» - Подпишите петицию! chng.it/cfrQ8LfM via @Change
Хорошее обсуждение получилось. Мне было бы интересно послушать отдельное обсуждение про стоимость разработки лекарств и проблемы регулирования фарм. рынка; в частности, может ли помочь увеличение сроков действия патентов
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Anna Yudenko retweeted
New preprint: spectral tuning in flavin-binding fluorescent proteins. Two-color imaging using LOV domains is also demonstrated! biorxiv.org/content/10.1101/…
Very happy to see our paper on engineering of a split LOV domain finally published @ACSSynBio! Congrats to @Aynya5, Anastasia, @IvanMasl0v and everyone else! pubs.acs.org/doi/10.1021/acs…
