Physician Scientist, Nephrologist. Interests: #AKI, #Uromodulin, Multiplex imaging & Spatial analytics, Immune mediated kidney injury. Investigator @KPMProject
Indiana, USA
Joined May 2017
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I am honored to be on the ballot for @ASNKidney Councilor at large. Truly thankful to all the support and encouragement!
Tarek M. Ashkar (El-Achkar) retweeted
Kidney casts contain high levels of PROM1, a marker linked to cell damage and dedifferentiation based upon new #ASNCJASN study. kidney.pub/CJASN0982
Registration link
iu.zoom.us/webinar/register/…
Preliminary agenda
nam12.safelinks.protection.o…
Save the Dates: May 20 & 21, 2026
The Indiana O’Brien Center for Advanced Renal Microscopy will host a virtual workshop on Spatial Protein Imaging. Details coming soon on the program and registration (free). Stay tuned!!
Thank you so much Carmen! So kind of you. Big kudos to all the team, but especially Azuma Nanamatsu who has been the driving force behind this work.
What proteins do kidney tubular casts contain? More than what you think but with notable absences. New in CJASN journals.lww.com/cjasn/abstr…
Times have changed. Reviewing papers stopped being predominantly a duty and an academic privilege, to also becoming an integral part of a multi-billion dollar publishing industry. Compensate reviewers? Any other examples of industry sustained by free work?
The Role of the Vascular Niche in Regulating Kidney Tubulo-Interstitial Fibrosis - Kidney International kidney-international.org/art…
This perspective in @asnpublications CJASN discusses the importance of spatial biology in studying kidney disease and the translational implications to identify therapeutic targets and biomarkers. journals.lww.com/cjasn/citat…
Happy to contribute to this superb work!
The lymphatic system has historically been understudied due to the difficulty of distinguishing it from the blood vasculature. This #ASNKidney360 paper's authors optimized an antibody-based method for imaging hard-to-visualize adult murine kidney lymphatics. Read more: kidney.pub/KID0919
Linking histology with Omics. Happy to contribute to this work that offers a really nice tool. @_hubmap nature.com/articles/s41467-0…
Kudos to all the team @IUKidney and all the collaborators and especially the participant heroes from @KPMProject who made this work possible
Kidney diseases are a leading cause of death in the U.S. They affect 14% of adults, often without knowing it. IU researchers are mapping kidney cell types to improve diagnosis and open the door to more precise therapies.
bit.ly/47HwKHE
Thanks! Yes, there were intermediary states THY1+, PROM1+(and VCAM1+), but loss of THY1 and persistence of PROM1 seems to correlate with injury and maladaptive repair.
Loss of THY1 and increase in PROM1+ PTs may be indicative of disease progression and can help stage kidney disease
Harnessing Spatial Biology- Protein and RNA
Our latest in @ScienceAdvances from a large collaboration through @KPMProject . We characterize a population of PTs in human kidney that express the regenerative marker THY1. THY1+ PTs are lost in kidney disease science.org/doi/10.1126/scia…
Tarek M. Ashkar (El-Achkar) retweeted
Kidney cells can protect themselves during injury, but the mechanisms were unclear.
ASCI member Tarek M. El-Achkar @AshkarLab & team @IUMedSchool now show that oxidative stress induces an isoform of uromodulin that re-routes to the mitochondria to enhance energy production.
View paper: jci.org/articles/view/183343
Very nice excited to see this work published and also the super well done editorial by @Vishal_D_Patel
Kidney cells can protect themselves during injury, but the mechanisms were unclear.
@AshkarLab & team @IUMedSchool now show oxidative stress induces an isoform of uromodulin that re-routes to the mitochondria to enhance energy production.
View paper: jci.org/articles/view/183343
Looking forward to this tomorrow!
How do trillions of cells work together to form & maintain the human body? @AshkarLab & @sarahteichmann1 will guide you through 3D & 4D spatial imaging, uncovering how organs function, develop, & respond to disease. Join the discussion! fcld.ly/hyh0vuq #CellMapCrew
