@AshkarLab

Physician Scientist, Nephrologist. Interests: #AKI, #Uromodulin, Multiplex imaging & Spatial analytics, Immune mediated kidney injury. Investigator @KPMProject

 Indiana, USA
medicine.iu.edu/faculty/5040/ashkar-tarek/
Joined May 2017
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  • Followers654
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Happy to contribute along with many other colleagues to the 2 Kidney papers bridging @KPMProject and @_hubmap that are just out today in @Nature and @NatureComms : nature.com/articles/s41586-0… nature.com/articles/s41467-0…

An atlas of healthy and injured cell states and niches in the human kidney

Nature - A high-resolution kidney cellular atlas of 51 main cell types, including rare and previously undescribed cell populations, represents a comprehensive benchmark of cellular states,...

nature.com
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I am honored to be on the ballot for @ASNKidney Councilor at large. Truly thankful to all the support and encouragement!
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Tarek M. Ashkar (El-Achkar) retweeted
ASN Publications
@asnpublicationsMar 25
Kidney casts contain high levels of PROM1, a marker linked to cell damage and dedifferentiation based upon new #ASNCJASN study. kidney.pub/CJASN0982
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Registration link iu.zoom.us/webinar/register/… Preliminary agenda nam12.safelinks.protection.o…

Video Conferencing, Web Conferencing, Webinars, Screen Sharing

Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom...

iu.zoom.us
Tarek M. Ashkar (El-Achkar)@AshkarLabFeb 12
Save the Dates: May 20 & 21, 2026 The Indiana O’Brien Center for Advanced Renal Microscopy will host a virtual workshop on Spatial Protein Imaging. Details coming soon on the program and registration (free). Stay tuned!!
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Save the Dates: May 20 & 21, 2026 The Indiana O’Brien Center for Advanced Renal Microscopy will host a virtual workshop on Spatial Protein Imaging. Details coming soon on the program and registration (free). Stay tuned!!
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What proteins do kidney tubular casts contain? More than what you think but with notable absences. New in CJASN journals.lww.com/cjasn/abstr…
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The secret of youth: posting a profile picture on the university website. Diamonds are forever.
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Times have changed. Reviewing papers stopped being predominantly a duty and an academic privilege, to also becoming an integral part of a multi-billion dollar publishing industry. Compensate reviewers? Any other examples of industry sustained by free work?
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The Role of the Vascular Niche in Regulating Kidney Tubulo-Interstitial Fibrosis - Kidney International kidney-international.org/art…
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This perspective in ⁦⁦@asnpublications⁩ CJASN discusses the importance of spatial biology in studying kidney disease and the translational implications to identify therapeutic targets and biomarkers. journals.lww.com/cjasn/citat…
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Happy to contribute to this superb work!
ASN Publications
@asnpublications3 Oct 2025
The lymphatic system has historically been understudied due to the difficulty of distinguishing it from the blood vasculature. This #ASNKidney360 paper's authors optimized an antibody-based method for imaging hard-to-visualize adult murine kidney lymphatics. Read more: kidney.pub/KID0919
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Linking histology with Omics. Happy to contribute to this work that offers a really nice tool. ⁦@_hubmap⁩ nature.com/articles/s41467-0…

FUSION: a web-based application for in-depth exploration of multi-omics data with brightfield...

Nature Communications - Border and colleagues present FUSION, an open-source, web-based platform designed to integrate spatial omics with histological context. FUSION enables intuitive, interactive...

nature.com
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Kudos to all the team @IUKidney and all the collaborators and especially the participant heroes from @KPMProject who made this work possible
IU School of Medicine@IUMedSchool19 Aug 2025
Kidney diseases are a leading cause of death in the U.S. They affect 14% of adults, often without knowing it. IU researchers are mapping kidney cell types to improve diagnosis and open the door to more precise therapies. bit.ly/47HwKHE
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Our latest in ⁦@ScienceAdvances⁩ from a large collaboration through ⁦@KPMProject⁩ . We characterize a population of PTs in human kidney that express the regenerative marker THY1. THY1+ PTs are lost in kidney disease science.org/doi/10.1126/scia…

Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regener...

The interplay in expression of the stem cell markers THY1 and PROM1 in kidney proximal tubules marks the timeline of disease.

science.org
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Loss of THY1 and increase in PROM1+ PTs may be indicative of disease progression and can help stage kidney disease Harnessing Spatial Biology- Protein and RNA
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Tarek M. Ashkar (El-Achkar) retweeted
ASCI
@the_asci19 Jun 2025
Kidney cells can protect themselves during injury, but the mechanisms were unclear. ASCI member Tarek M. El-Achkar @AshkarLab & team @IUMedSchool now show that oxidative stress induces an isoform of uromodulin that re-routes to the mitochondria to enhance energy production. View paper: jci.org/articles/view/183343
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Very nice excited to see this work published and also the super well done editorial by @Vishal_D_Patel
Journal of Clinical Investigation
@jclinicalinvest19 Jun 2025
Kidney cells can protect themselves during injury, but the mechanisms were unclear. @AshkarLab & team @IUMedSchool now show oxidative stress induces an isoform of uromodulin that re-routes to the mitochondria to enhance energy production. View paper: jci.org/articles/view/183343
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Congratulations to Mike Eadon ⁦@EadonLab⁩ and Takashi Hato from ⁦@IUKidney⁩ for being inducted to ⁦@the_asci⁩ !!!!!
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Looking forward to this tomorrow!
Leica Microsystems
@LeicaMicro14 Apr 2025
How do trillions of cells work together to form & maintain the human body? @AshkarLab & @sarahteichmann1 will guide you through 3D & 4D spatial imaging, uncovering how organs function, develop, & respond to disease. Join the discussion! fcld.ly/hyh0vuq #CellMapCrew
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Happy to share this work in @jclinicalinvest led by superstar Azuma Nanamatsu. We found a splice variant of Uromodulin directed intracellularly to mitochondria to enhance energy metabolism and protect TAL cells from injury. jci.org/articles/view/183343
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Splice switching antisense oligonucleotide that enhance this splice Uromodulin variant can improve the course of acute kidney injury. Many thanks to all collaborators @IUKidney @KPMProject
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