@CanAkerman

Postdoctoral Fellow @johnshopkins, Rothstein lab, studying neurodegeneration. Previously: McGill, ETH Zurich, Penn State

500px.com/p/scanakerman?view=photos
Joined May 2021
  • Tweets613
  • Following244
  • Followers254
3Media
Suleyman Can Akerman retweeted
ShorterLab@ShorterLab
Sep 24
Spatiotemporal characterization of Alzheimer disease pathology in living human brain tissue: nature.com/articles/s41467-0…

Spatiotemporal characterization of Alzheimer disease pathology in living human brain tissue

Nature Communications - This study uses brain biopsies collected during shunt surgery to examine early Alzheimer disease in living brain tissue, showing rapid tau turnover and stable amyloid plaques.

nature.com
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Suleyman Can Akerman retweeted
John Lukens@LukensJohnR
Sep 17
The sphingosine-1-phosphate receptor functional antagonist fingolimod exacerbates neuroinflammation and tau pathology in a mouse model of tauopathy biorxiv.org/content/10.64898…
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Great to be part of #ALSNexus26 last week! I presented our work on modulating extracellular vesicles to inhibit dipeptide repeat propagation in C9-ALS, both in the Emerging Science session and as a poster. Great discussions across the ALS community. #ALS
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Distinct Transcriptional States of TDP-43 Pathology in an Alzheimer’s Disease Mouse Model link.springer.com/article/10…

Distinct Transcriptional States of TDP-43 Pathology in an Alzheimer’s Disease Mouse Model

Neuroscience Bulletin - Alzheimer’s disease (AD) is frequently accompanied by cytoplasmic TDP-43 inclusions, although its pathogenic role remains unclear. Using Immuno-LCM-RNAseq in...

link.springer.com
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Distinct brain extracellular vesicle microRNA profiles differ in frontotemporal dementia and Alzheimer’s disease academic.oup.com/braincomms/…

Distinct brain extracellular vesicle microRNA profiles differ in frontotemporal dementia and...

Morgan et al. report specific Alzheimer’s disease and frontotemporal dementia brain-derived small extracellular vesicle microRNA cargoes associated with au

academic.oup.com
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Human chaperone DNAJB6b suppresses tau fibril formation through co-aggregation nature.com/articles/s42004-0…

Human chaperone DNAJB6b suppresses tau fibril formation through co-aggregation

Communications Chemistry - Human chaperone DNAJB6b has emerged as a key component involved in the endogeneous defense system against tau protein aggregation in the context of Alzheimer’s...

nature.com
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TMEM106B haplotypes show distinct associations with tau and TDP-43 pathologies in the aging brain medrxiv.org/content/10.64898…

TMEM106B haplotypes show distinct associations with tau and TDP-43 pathologies in the aging brain

A central challenge in post-GWAS biology is determining how inherited variation within disease-associated loci shapes molecular mechanisms and clinical phenotypes. Here, we examined four previously...

medrxiv.org
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The UNC13A cryptic exon associateswith cognitive impairment in Alzheimer’sdisease link.springer.com/article/10…

The UNC13A cryptic exon associates with cognitive impairment in Alzheimer’s disease

Alzheimer's Research & Therapy - TAR DNA-binding protein of 43 kDa (TDP-43) is often found in the brains of patients with Alzheimer’s disease (AD), where it co-occurs with...

link.springer.com
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Multi-omics of C9orf72 spinal cord organoids reveal convergent molecular signatures and targets researchsquare.com/article/r…

Multi-omics of C9orf72 spinal cord organoids reveal convergent molecular signatures and targets

Background: amyotrophic lateral sclerosis is the most common adult-onset motor neuron disease, characterised by the progressive degeneration of upper and lower motor neurons in the brain and spinal...

researchsquare.com
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NAT10 inhibition corrects nuclear defects in tau mutant human neurons and extends lifespan in a Drosophila tauopathy model sciencedirect.com/science/ar…
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TBC1D9 and TBC1D9B are ARL8 effectors that modulate exosome secretion through a RAB11A–exocyst pathway pnas.org/doi/full/10.1073/pn…

TBC1D9 and TBC1D9B are ARL8 effectors that modulate exosome secretion through a RAB11A–exocyst...

Multivesicular endosomes (MVEs) are endolysosomal compartments containing intraluminal vesicles (ILVs) that follow two alternative pathways: fusion...

pnas.org
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Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer’s disease nature.com/articles/s41593-0…

Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer’s...

Nature Neuroscience - Researchers identify mitochondrial plaques, a previously unrecognized and highly acidic mitochondria-based pathological structure in Alzheimer’s disease, and demonstrate...

nature.com
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SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain science.org/doi/10.1126/scia…

SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain

The AD risk gene SORL1 suppresses degeneration and key transcriptomic changes in a tauopathy mouse model.

science.org
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Cell-type signatures of Alzheimer’s disease shared across population groups nature.com/articles/s41586-0…

Cell-type signatures of Alzheimer’s disease shared across population groups

Nature - Single-nucleus RNA-seq and ATAC-seq analyses on post-mortem brain samples from African American, Latin and white individuals identify cell-type-specific molecular signatures that are...

nature.com
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Suleyman Can Akerman retweeted
Charlotte Fare@charlotte_fare
Jun 18
Tau Disaggregation by a CNS-Permeable Small Molecule Reduces Fibril and Oligomer Burden and Preserves Proteostasis and Behavior biorxiv.org/content/10.64898…

Tau Disaggregation by a CNS-Permeable Small Molecule Reduces Fibril and Oligomer Burden and...

Pathological tau aggregates drive neuronal dysfunction in Alzheimer’s disease (AD) and related tauopathies, yet no approved therapy eliminates existing tau neurofibrillary tangles. Here, we report...

biorxiv.org
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A new study profiled tau inside human brain-derived vesicles: the PHF6 (VQIVYK) motif is the seeding-compentent cargo. Blocking PHF6 could be a way to stop tau pathology in its tracks. link.springer.com/article/10…

Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau...

Journal of Biomedical Science - Tauopathies are neurodegenerative diseases all characterized by tau lesions in the brain. Nevertheless, a clinical and pathophysiological heterogeneity is present...

link.springer.com
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Intersting preprint: blocking VPS4a could keep TDP-43 out of exosomes without stopping exosome production. That would suggest that one might be able to block the neuron-to-neuron spread of pathology without shutting down normal vesicle trafficking. biorxiv.org/content/10.64898…

ESCRT Machinery Dysfunction in Motor Neurone Disease: TSG101, CHMP2B, and VPS4a Differentially...

Motor Neurone Disease (MND) is characterised by progressive degeneration of upper and lower motor neurons, accompanied by cytoplasmic mislocalisation and hyperphosphorylation of TDP-43 — hallmarks...

biorxiv.org
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Suleyman Can Akerman retweeted
John Lukens@LukensJohnR
Jul 7
Injury-induced tau pathology promotes aggressive behavior in Drosophila without neurodegeneration | PNAS pnas.org/doi/10.1073/pnas.26…
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Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgliosis, and memory decline in APP knock-in mice cell.com/cell-reports/fullte…

Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgli...

Two approved Alzheimer’s disease immunotherapies clear amyloid β-protein (Aβ), a salient target, but with somewhat limited efficacy. Yang et al. use an all-human neuronal tau screen to identify B28,...

cell.com
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Arc mediates intercellular tau transmission via extracellular vesicles cell.com/cell/fulltext/S0092…

Arc mediates intercellular tau transmission via extracellular vesicles

Tau pathology spreads cell to cell in Alzheimer’s disease, but the molecular mechanisms are unclear. This study found that the capsid-forming protein Arc binds and packages tau into extracellular...

cell.com
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