Amal Amer MD PhD | Dept of MI&I OSUCOM | autophagy, inflammasomes & immune responses in Alzheimer's disease, COVID-19, & Legionella infection 🧠🦠🔬👩🏽‍🔬

Joined September 2020
Amer Lab retweeted
A finding in mice suggests a new target for severe #COVID19 capable of dampening harmful inflammation while enhancing antiviral immunity: doi.org/10.1172/jci.insight.… Mostafa M. Eltobgy @mostafaeltobgy2, Amal Amer @AmerLabOSU @OSUWexMed @OhioStateMed @OhioStateNeuro discover that blocking the inflammatory protein caspase-11 restores virus-fighting T cells and improves viral clearance in mice. The figure: CASP11 deficiency in hematopoietic immune cells enhances survival, reduces inflammation, and promotes T cell response after SARS-CoV-2 infection. #SARSCoV2
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Excited to share our new study in @JCI_insight . We show that Caspase-11–driven hyperinflammation impairs antiviral CD8⁺ T cell immunity and delays viral clearance during severe SARS-CoV-2 infection. insight.jci.org/articles/vie…
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Our work is finally out in @JCI_insight ! Using immunopeptidomics, bioinformatics & T-cell assays we discovered novel CD4⁺ T cell-recognized B. pertussis antigens that reduce airway colonization. A long journey and a fantastic collaborative effort! insight.jci.org/articles/vie……
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Congratulations to our wonderful PI Dr. Amer on receiving the Hedwig van Ameringen Executive Leadership in Academic Medicine (ELAM) Fellowship alongside 5 other distinguished colleagues! We thank her for her outstanding leadership and look forward to her continued success! 👏
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We're excited to announce that Dana M. McTigue, PhD, has been named Vice Dean for Research at #OSUCOM, pending approval by the Board of Trustees. Dr. McTigue has served as the college’s Associate Dean for Foundational Research since 2021. Congratulations Dr. McTigue! ♥️
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Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection @biorxivpreprint @mostafaeltobgy2 biorxiv.org/content/10.1101/…
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We are proud to be ranked on the @USNews "Best Hospitals" list in recognition of our dedication to providing safe, compassionate, leading-edge medical care. We're honored to be named the top hospital in central Ohio with 9 nationally ranked specialties.wexnermedical.osu.edu/mediar…
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Axios: 'The cure for long COVID may come from Ohio State' 'Ohio State researchers are working toward a cure for long COVID, supported by the school's largest grant ever received for an infectious diseases study' axios.com/local/columbus/202…
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At Ohio State University, researchers found that SARS-CoV-2-infected mice showed long COVID-like brain fog weeks after infection. Using AI and automated behavioral tests, they linked these deficits to gene changes also seen in human patients. biorxiv.org/content/10.1101/…
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Announcing, one of a unique conference. #CellDeath, #Innateimmunity, and #Autophagy. Top speakers, top Science. website -open soon- Please retweet. @EMBO @India_Alliance @ccmb_csir @CSIR_IND @jkagan1 @dixitvishva @vpderetic @v_hornung @ThiruKanneganti @ClareBryant13 @iDikic2
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NPR: 'A push to understand long COVID' 'The National Institutes of Health announced a $300 million investment to research treatments for long COVID' 'In the US, there are an estimated 17M adults with LC. Many unable to work or care for their families' npr.org/2024/12/23/g-s1-3971…
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Discover The JI’s Brief Reviews - These insightful articles cover emerging and evolving areas in #immunology, while also providing a balanced view of the current #research. Explore the series now: ow.ly/5HXq50U0BFL. #ReadTheJI
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Are you a grad student or #postdoc looking to improve your peer review skills? This FREE webinar is for you! Learn from the experts and register today: ow.ly/X8lw50ToaYc. #ScienceCareers #Immunology
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Amazing night talking about life and science with our speaker @TheColonnaLab of the joint campus-wide #immunology seminar series, along with @EugeneOltz, @AmerLabOSU and Prosper Boyaka!! @OhioStatePIIO @OSUWexMed @OhioStateMed
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'..and better understand the long-term consequences of the virus. They recently received a $15 million federal grant from the NIH to find solutions to long COVID. This Tuesday, we will speak to the project lead about their progress thus far.'
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