Senior fellow @UniofOxford @NDCNOxford @OxSCNi
Joined July 2018
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1/ Pleased to share our latest work @thomaskrieglab & @Mito_Redox
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke
sciencedirect.com/science/ar…
Amin Mottahedin retweeted
Have you wondered how #circadian mechanisms and the time of day affects #stroke risk, outcome, therapy? Is #chronotherapy possible in stroke?
I am very excited to share our review on "Stroke in the time of Circadian Medicine" in @CircRes ahajournals.org/doi/10.1161/… 1/5
Amin Mottahedin retweeted
Happy to share our review with @echouchani on recent advances in cysteine proteomics! @HarvardCellBio @DFCI_CancerBio
authors.elsevier.com/c/1idmT…
Amin Mottahedin retweeted
Hi everyone! The official advert for the immunometabolism position in our lab is now out. To all freshly minted PhD and postdoc, please, apply here if you have experience in macrophage biology and metabolism, we need you!
there is a really exciting project waiting for you!
Amin Mottahedin retweeted
Below the link to the BBC Radio 4 programme - everything you ever wanted to know about mitochondria but were afraid to ask...
bbc.co.uk/sounds/play/m001md…
Amin Mottahedin retweeted
We need to talk about MitoSOX...
There are a number of issues with MitoSOX/hydroethidine as "superoxide" probes.
One approach from Richard Hartley's lab and mine is to use MitoNeoD/NeoD. Give it a go and let us know if it works for you.
sciencedirect.com/science/ar…
Amin Mottahedin retweeted
Are you an #immunometabolism enthusiast? I'm excited to share our latest work out now in @Nature. This work was jointly led by @AlexHooftman, @ChristianGPeace & I, examining mitochondrial TCA cycle function in inflammatory macrophages 1/n
nature.com/articles/s41586-0…
Amin Mottahedin retweeted
Happy to share the results of our collab with @LabPrudent, led by @vincentZecchin1 and Vincent Paupe @Nature ! We show that Fumarate drives mtDNA release in the cytosol via mitochondrial-derived vesicles (MDVs) to trigger innate immunity! nature.com/articles/s41586-0…
Amin Mottahedin retweeted
Delighted to see this - it represents a painstaking development of. a method by Fay Allen, overseen by Andrew James.
This will hopefully be useful to the field - in metabolomics speed of isolation is (nearly...) everything...
FEBS Press febs.onlinelibrary.wiley.com…
3/
- Succinate accumulation is a conserved response to ischemia in human and mouse brain
- Blocking succinate oxidation at reperfusion protects the brain against acute IR injury after #stroke
4/4 Thanks to our wonderful collaborators and co-authors (Some not on Twitter) @hiranprag @_Christina_Sch @FrezzaLab @lordan_jee @asorby_adams @burger_nils @DrMHuang @Dr_LPJ @Pluchinolab @AstraZeneca
Amin Mottahedin retweeted
Latest paper from our collaboration with @thomaskrieglab
In work led by @hiranprag we show that mice lacking Cyclophilin D don't accumulate succinate during ischemia - now we need to find out how this happens
authors.elsevier.com/c/1ft0e…
Amin Mottahedin retweeted
The world wants justice for #Mahsa_Amini ✊
Amin Mottahedin retweeted
Extremely pleased to share our latest work (@thomaskrieglab and @Mito_Redox) on the ischemia-selective protection against cardiac ischemia/reperfusion (IR) injury by malonate, out now in @CircRes.
ahajournals.org/doi/10.1161/…
(open access - so freely available!)
1/7
Amin Mottahedin retweeted
Delighted to share our new work out in @CellChemBiol. This work was led by Andrew James and our long standing collaboration with @ChemBioGlasgow lab. Check out the link below ⬇️⬇️⬇️1/n
sciencedirect.com/science/ar…
Amin Mottahedin retweeted
In press @CircAHA 🤩, the secret to increasing birth of new CM in aging heart: exercise. Excited for this work with Carolin @CLerchenmueller, Tony @rosenzweig_a and Rich T Lee (not on twitter) @Harvard, @HSCRB. Special thanks to all co-authors!
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