Postdoc research associate at the University of Cambridge. Pre-clinical drug development for ischaemic stroke @thomaskrieglab @Mito_Redox
Joined December 2020
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Jordan Lee retweeted
Explore novel therapeutic opportunities in #stroke this #WorldStrokeDay
Local arterial administration of acidified malonate as an adjunct therapy to thrombectomy may attenuate ischaemia–reperfusion injury &⬇️brain damage up to 60%
academic.oup.com/cardiovascr…
#CardiovascularResearch
🚨 Local adminstration of acidified malonate (aDSM) at reperfusion protects against stroke ischaemia-reperfusion injury. This work opens up a new therapeutic opportunity for stroke patients and to improve outcomes.
@ESC_Journals
📖 academic.oup.com/cardiovascr…
Thanks to amazing collaborators & support from @Cambridgecardio, @TheBHF @MRC_MBU, and @wellcometrust. @Mito_Redox @thomaskrieglab 🙏
#Stroke #CardiovascularResearch #Spinout #Startup #Therapeutics
Jordan Lee retweeted
🚨 New paper out from us, reveals a novel role for mitochondrial RET-ROS in #HFpEF. 🧬 ND6 mutation ➡️ 🫀 Hypertrophy 💔 Diastolic dysfunction 🏃♂️ ↓ Exercise capacity 💪 ↑ Lean mass 🍩 HFD worsened metabolism ✅ Exercise reversed many effects!
doi.org/10.1152/ajpheart.004…
Jordan Lee retweeted
Our stroke research has been featured in this month’s @TheBHF newsletter. Check it out.
comms.bhf.org.uk/cr/AQiXsA0Q…
Jordan Lee retweeted
Have a look at our new story demonstrating chronic benefits against heart failure when malonate is given at reperfusion. @Mito_Redox @hiranprag @AnaVujic5
Malonate at reperfusion attenuates post-infarct heart failure.
link.springer.com/article/10…
ALT Schematic of malonate inhibition of IRI in MI. Ischemia-accumulated succinate is rapidly oxidized on reperfusion by SDH upon reperfusion. This drives the ROS burst at reperfusion via RET at complex I, which subsequently primes cardiomyocytes for cell death and leads to post-MI HF. Malonate inhibits SDH, slowing down succinate oxidation and ROS production on reperfusion, reducing cell death. Malonate entry into cardiomyocytes can be enhanced by ischemia or low pH, driving the entry of monocarboxylate malonate via MCT1. Whether malonate can prevent post-MI HF by preventing RET-ROS on reperfusion is currently unknown. (MCT1 monocarboxylate transporter 1, DIC dicarboxylate carrier, SDH succinate dehydrogenase, CxI complex I, RET reverse electron transport, ROS reactive oxygen species, TCA tricarboxylic acid cycle, EF ejection fraction)
Jordan Lee retweeted
Jordan @lordan_jee presented our group with a nice e-poster at the @ESOstroke meeting in Basel. Great story of malonate protecting against ischemic stroke.
Jordan Lee retweeted
Have a look at our recent review highlighting RET as a potential treatment against IR injury. @hiranprag @Mito_Redox link.springer.com/article/10…
Jordan Lee retweeted
Exciting news! I am recruiting, and looking for a talented Research Assistant. If you're passionate about heart failure and want to be part of an innovative and dynamic research team, I want to hear from you! Link: jobs.cam.ac.uk/job/41220/
@Cambridge_Uni, @Cambridgecardio
Amazing news @AnaVujic5, much deserved and can't wait to see the exciting research that the Vujic lab will produce.
Huge congratulations to Ana @AnaVujic5 on receiving the prestigious @TheBHF Intermediate Research Fellowship and becoming a PI! Thrilled and very proud of this.
@Mito_Redox @Cambridgecardio @MedCambridge @TVPLab
Jordan Lee retweeted
We had a wonderful time and great science at our Mitochondrial Therapy Group MTG meeting at Caius College. @Mito_Redox @RyanLab_MBU @AnaVujic5 @SaebParsy @dunjaaks @hiranprag @Richard Hartley
Jordan Lee retweeted
🚨To #immunometabolism and #mitochondria lovers everywhere🚨
There is an opportunity to join the newly minted Ryan group @MRC_MBU @Cambridge_Uni as a postdoctoral research associate.
Please check out the advert below and I appreciate any shares⬇️⬇️⬇️
nature.com/naturecareers/job…
Have a read of @AMottahedin latest work on targeting succinate dehydrogenase in ischaemic stroke which I am pleased to be part of. It has some neat mass spec imaging as well! @thomaskrieglab @Mito_Redox
sciencedirect.com/science/ar…
1/ Pleased to share our latest work @thomaskrieglab & @Mito_Redox
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke
sciencedirect.com/science/ar…
Delighted to present my research today at the Department of Medicine Research Day. Got the best poster award for it too! @thomaskrieglab @MedCambridge
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Jordan Lee retweeted
Prag & colleagues demonstrate that #malonate selectively enters at risk tissue during #IR to block #SDH & cardiac damage. Learn more at ahajrnls.org/3REYa6c
@hiranprag @thomaskrieglab @dunjaaks @astrazenecaUK @DrJReinhold @cambridgecardio @MRCMBU
Jordan Lee retweeted
Malonate, a natural chemical in our bodies, helps to stop further damage following a heart attack. Our collaboration supporting @cambridge_uni and @mrc_mbu revealed how malonate enters damaged heart muscle, which could help to target future therapies. know.az/3RDC7wn
Jordan Lee retweeted
Extremely pleased to share our latest work (@thomaskrieglab and @Mito_Redox) on the ischemia-selective protection against cardiac ischemia/reperfusion (IR) injury by malonate, out now in @CircRes.
ahajournals.org/doi/10.1161/…
(open access - so freely available!)
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