@wtmatlock

wellcome early-career award fellow @milnercentre | formerly @oxfordbiology and @modmedmicro

 he/him
willmatlock.co.uk
Joined July 2020
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10Media
🚨 New preprint! 🚨 We reveal that blaTEM-1 expression varies across the E. coli phylogeny, driving differences in co-amoxiclav resistance: biorxiv.org/content/10.1101/…

E. coli phylogeny drives co-amoxiclav resistance through variable expression of blaTEM-1

Co-amoxiclav resistance in E. coli is a clinically important phenotype associated with increased mortality. The class A beta-lactamase bla TEM-1 is often carried by co-amoxiclav-resistant pathogens,...

biorxiv.org
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Today my first editorial article came out! It's both an intro to my Monash Bioethics Review special issue on antimicrobial stewardship and social justice, and also an original article examining issues with the precautionary principle as a justification. link.springer.com/article/10…

Stewardship and social justice: implications of using the precautionary principle to justify...

Monash Bioethics Review - Antimicrobial resistance has been termed a ‘silent pandemic’, a ‘hidden killer.’ This language might indicate a threat of significant future harm...

link.springer.com
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Will Matlock retweeted
Jose A Escudero@jaegc
29 Oct 2024
Finally out after peer review, our update on the integron model showing that translation rates of cassettes in first position influence the phenotypes conferred by others downstream. Great effort by @AndrePCarvalho nature.com/articles/s41467-0…
https://www.nature.com/articles/s41467-024-53525-6

ALT https://www.nature.com/articles/s41467-024-53525-6

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So exciting to see our (Liam Shaw, @Sheppard_Lab, @EpicFeil_) piece on the current state of plasmid epidemiology is now out: microbiologyresearch.org/con… @NDMOxford @OxfordBiology @IneosOxford @MilnerCentre

Towards quantifying plasmid similarity

microbiologyresearch.org
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A thread on our study… (1/10)
Will Matlock@wtmatlock
12 Aug 2024
🚨 New preprint! 🚨 We reveal that blaTEM-1 expression varies across the E. coli phylogeny, driving differences in co-amoxiclav resistance: biorxiv.org/content/10.1101/…

E. coli phylogeny drives co-amoxiclav resistance through variable expression of blaTEM-1

Co-amoxiclav resistance in E. coli is a clinically important phenotype associated with increased mortality. The class A beta-lactamase bla TEM-1 is often carried by co-amoxiclav-resistant pathogens,...

biorxiv.org
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more replies
2) How can we routinely incorporate phylogenetic information into AMR phenotype prediction? Hybrid assemblies are not always possible, so we need shortcuts. (9/10)
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Thanks for reading and let me know if you have any questions! (10/10)
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E. coli phylogeny drives co-amoxiclav resistance through variable expression of blaTEM-1 biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Ever wondered how fast accessory genome dynamics of bacteria really is? In a new preprint we (@mrcmolari, Liam Shaw) explore how rapidly E coli picks up genes horizontally, breaks genome synteny, etc.. biorxiv.org/content/10.1101/… For a thread by Marco see mstdn.science/@mrcmlr/112772…

Evolutionary dynamics of genome structure and content among closely related bacteria

Bacterial genomes primarily diversify via gain, loss, and rearrangement of genetic material in their flexible accessory genome. Yet the dynamics of accessory genome evolution are very poorly unders...

biorxiv.org
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For fun - but you might win a cuddly Microbe....if you have kids interested in art/drawing or science, why not ask them to draw a picture of a Microbe (easy to search online) and send them to us (details below) @BashTheBug . Or - no age limit - have a crack yourself! Please RT!!
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Will Matlock retweeted
Ed Feil@EpicFeil_
5 Jun 2024
Great meeting yesterday of the @JPIAMR network on plasmid epidemiology (TEAPOTS) here at @MilnerCentre Bath Uni . Excellent talks from @TMcoque @_natachacouto_ @ZaminIqbal @wtmatlock @ccoluzzi1 @sophia_david3 @MohsinMashkoor Liam Shaw, Val Fernandez and Teresa Noguera. Thanks!!
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Communication, Narratives and Antimicrobial Resistance - summary of conference co-organized with @DrSallyFrampton, @drtessjohnson @wtmatlock Supported by TORCH Medical Humanities @OxMedHum and Uehiro Centre for Practical Ethics @ethicsinthenews torch.ox.ac.uk/article/commu…

Communication, Narratives and Antimicrobial Resistance

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Please RT: Funded PhD project (UK students) on the ecology and evolution of antibiotic resistance 🦠🧬🫁 at Queen’s University Belfast. Application deadline: 21 June Please 📧 me with any questions, happy to chat! findaphd.com/phds/project/ho…

How do interactions in the microbiome shape the evolution of antibiotic resistance in bacterial...

PhD Project - How do interactions in the microbiome shape the evolution of antibiotic resistance in bacterial pathogens? at Queen’s University Belfast, listed on FindAPhD.com

findaphd.com
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