Prof@Oxford_NDPH, Hon.Nephrologist, EMPA-KIDNEY & EASi-KIDNEY CI. Join the fight against CKD, systematic bias & random error: make studies larger & randomized!

Oxford, England
Joined April 2016
Great hashtag! #StampOnCKD
Replying to @willkidney
@willkidney + @kevin_damman bring the heart of nephrology to the heart of Munich #StampOnCKD @escardio @MarkusAtHome Test for CKD in all ❤️ patients Provide Nephroprotective Therapy Give iv CM whenever needed Prefer DOAC over VKA for most CKD pat
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Will Herrington retweeted
The focused update of the KDIGO 2027 CKD Guideline is available for public review through November 4, 2026. KDIGO invites the global kidney community to review the draft and share feedback to help inform and improve the final update. Visit the KDIGO CKD Guideline website to download the draft and share your comments via the feedback survey: kdigo.org/guidelines/ckd-eva… The focused update addresses new evidence since publication of the KDIGO 2024 CKD Guideline on SGLT2 inhibitors, GLP-1-based therapies, and nsMRAs in people with CKD, excluding those receiving dialysis or who have received a kidney transplant. Thank you for your time and insights.
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Have a read - this is a kidney example, but there may be much wider implications if we start applying polygenic risk scores developed in general populations to populations with disease. Results could be qualitatively completely misleading in patients with prevalent disease…
Now open access in @NDTsocial @willkidney Impact of selection bias on the association of kidney function polygenic scores with CKD progression 🧐Using PGS in populations selected for prevalent disease may lead to misleading conclusions ▶️academic.oup.com/ndt/article…
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Will Herrington retweeted
Antithrombotic therapy in CKD after the 2026 @escardio @ERAkidney guidelines: clarity versus certainty academic.oup.com/ndt/article… @accovic @DrAlexBurlacu @NDTsocial @hjanders_hans
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Nephrology rocks #ESCCongress @willkidney @kevin_damman @RonGansevoort Diana Gorog @jozinetm #StampOnCKD before a really huge audience 2026 @escardio @ERAkidney CKD GL "Jetzt wächst zusammen, was zusammengehört" (Now, what belongs together is growing together) Willi Brandt
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Did you catch Prof Will Herrington's talk on 2026 ESC Guidelines for the management of cardiovascular disease and chronic kidney disease at #ESCCongress? The guidelines were published earlier today with @escardio and European Renal Association (ERA) ➡️ academic.oup.com/eurheartj/a…
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🚨 First ESC guideline dedicated to CVD + CKD at #ESCCongress. The key message: CKD should actively change cardiovascular management, not simply appear on the problem list. New STAMP on CKD framework: Screen Triage Address CKD risk Modify CVD management Plan care Major practical points: 🔹 Screen ALL patients with CVD using eGFR + albuminuria 🔹 SBP target 120-129 mmHg if tolerated when eGFR ≥30 🔹 ACEI/ARB + SGLT2i for most appropriate CKD patients 🔹 SGLT2i can be initiated at eGFR ≥20 🔹 Finerenone and GLP-1RA gain important roles in diabetic CKD 🔹 HF + CKD: SGLT2i irrespective of LVEF, with more aggressive decongestion when diuretic resistance develops 🔹 And an important clinical reminder: Kidney disease should not unnecessarily delay cardiovascular investigation or intervention. Treat the cardiorenal patient as one physiology, not two separate organs. @escardio @ERAkidney @ESC_Journals @willkidney @kevin_damman #CKD #Cardiorenal #HeartFailure
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Will Herrington retweeted
Replying to @willkidney
@willkidney + @kevin_damman bring the heart of nephrology to the heart of Munich #StampOnCKD @escardio @MarkusAtHome Test for CKD in all ❤️ patients Provide Nephroprotective Therapy Give iv CM whenever needed Prefer DOAC over VKA for most CKD pat
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🎉EASi-KIDNEY has recruited 7000 randomised participants! 📉EASi-KIDNEY will investigate whether a novel treatment can help slow the progression of chronic kidney disease (CKD) ➡️ buff.ly/qXd6j1S
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Today: EASi-KIDNEY=6609 participants=EMPA-KIDNEY! Brilliant patients, clinics and hospitals from 500+ sites are growing larger renal trials & wider collaborations. 🙏 🙏 🙏 🤩 Just a few more thousand volunteers patients needed…..
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Congratulations @hjanders_hans and @NDTsocial (great to see journals grow)
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10,000 screened up on the same day!
🎉EASi-KIDNEY has recruited 6000 randomised participants! 📉EASi-KIDNEY will investigate whether a novel treatment can help slow the progression of chronic kidney disease (CKD) ➡️buff.ly/qXd6j1S
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Will Herrington retweeted
Now open access in @NDTsocial UACR and UPCR with kidney failure: a pooled analysis of clinical trials 🧐UACR and UPCR are robust predictors of kidney failure, but UACR has stronger associations, particularly in CKD+diabetes. ▶️academic.oup.com/ndt/article…
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Now open access in @NDTsocial @ERAkidney ERA’s ABCDE framework for kidney disease prevention: turning the WHO kidney health resolution into action ▶️academic.oup.com/ndt/article…
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Extraordinarily large effects of #SGLT2i on urinary uromodulin (unexpected & a call to reverse translational science to understand better the mechanisms of renal benefits of SGLT2i). @grecombm @Oxford_NDPH DPhil.
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#EASi-KIDNEY showing how a group of >450 amazingly motivated local clinical sites can surpass EMPA-KIDNEY (n=6609). EASi-KIDNEY has ~4850 randomized pts with #CKD & ~2000 in run-in. This forecasts overtaking EMPA-KIDNEY in late May. Deep gratitude to all from @Oxford_NDPH
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EASi-KIDNEY teams globally just screened 800 pts with #CKD a month on average for 5 months in succession. Mind-blowing commitment! @DCRINews @GeorgeInstIN @TrialsCentre @ChristophWanne4 @_anmco @adeeralevin @OtavioBerwanger @KatherineTuttl8 @P_Rossing @TorBiering @DitteHansen7
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Will Herrington retweeted
CKD and HF: Conclusions from a KDIGO Controversies Conference Unfortunately submitted before publication of presentation of DIGIT-HF and DECISION 😆 @JBauersachsMD kidney-international.org/art…
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📣SGLT2 inhibition for patients with ADPKD – closing the evidence gap 👉 an @erakidney e-seminar of the ERA Journal Club Speaker: @MuellerRom Moderator: @willkidney , Parminder Judge Panelist: Roslyn Simms
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