Proud to be part of this research
Our group is recognized as one of the world leaders in HD doi.org/10.1002/14651858.CD0…
Adrian Covic retweeted
France followed all of Krugman's recommendations: Big government spending, high taxes, migration. Now...
Nobel winner Krugman says France may have become 'too big to save' and 'unsustainable fiscal path'.
cnb.cx/4hDK84t
Adrian Covic retweeted
RIP Jeffrey Archer.
What an irrepressible, ebullient character. Sold gazillions of books, raised gazillions for charity, loved his Krug, parties, politics and cricket, survived scandal and prison, and had me laughing to the end as our last text exchange on Sunday shows.
Adrian Covic retweeted
En enfermedad renal crónica G3a y triglicerios ≥150 mg/dL, combinar estatinas y fenofibrato, comparado solo estatinas; se asoció a ↓7% el riesgo del evento cardiovascular mayor y ↓21 el de necesitar diálisis. Además fue seguro
CKJ 2026
academic.oup.com/ckj/advance…
Adrian Covic retweeted
Here’s the conclusions in the abstract. These are all surrogate endpoints that are not validated as improving survival. IMO these are not worth to time and cost of trials.
Now online in @NDTsocial
Beyond Kt/V: Redefining Dialysis Adequacy as Targeted CV Risk Reduction
🧐 Future trials should be multicenter, phenotype-enriched, mechanism-specific, adequately powered, and endpoint-adjudicated.
▶️academic.oup.com/ndt/article…
Adrian Covic retweeted
Now online in @NDTsocial
Beyond Kt/V: Redefining Dialysis Adequacy as Targeted CV Risk Reduction
🧐 Future trials should be multicenter, phenotype-enriched, mechanism-specific, adequately powered, and endpoint-adjudicated.
▶️academic.oup.com/ndt/article…
Adrian Covic retweeted
El manejo antitrombótico y antiplaquetario en personas con enfermedad renal crónica avanzada tiene más dudas que respuestas, aquí las de mayor evidencia
NDT2026
academic.oup.com/ndt/advance…
Adrian Covic retweeted
Antithrombotic therapy in CKD after the 2026 ESC guidelines: clarity versus certainty
doi.org/10.1093/ndt/gfag218
Adrian Covic retweeted
Hey #NephJC 👋
Checkout the VA by @DivyaveerSSNeph
This week we're looking at steroid weaning strategies in adults with podocytopathies (MCD/FSGS).
💊Steroids: easy to start but hard to stop.
#NephTwitter
nephjc.com/news/starttrial
Adrian Covic retweeted
Antithrombotic therapy in CKD after the 2026 @escardio @ERAkidney guidelines: clarity versus certainty
academic.oup.com/ndt/article…
@accovic @DrAlexBurlacu
@NDTsocial @hjanders_hans
Adrian Covic retweeted
Each small step up in the greenery around a person's home came with a 4 percent lower risk of dying over the years they were tracked, across more than 8.3 million people in seven countries. Seven of the nine studies behind that figure found the link on their own.
David Rojas-Rueda of Colorado State University and ISGlobal in Barcelona led the review with colleagues including Mark Nieuwenhuijsen, and the World Health Organization funded it. They pooled nine cohort studies, which follow the same people over years, covering 8,324,652 adults in Australia, Canada, China, Italy, Spain, Switzerland and the United States. The Lancet Planetary Health published it in 2019.
Greenery was measured from satellites as NDVI, a score of how much living green leaf covers the ground. Zero means no vegetation, and about 0.8 to 0.9 means the densest leaf cover possible. Every 0.1 rise within 500 metres of home is roughly a ninth of the way from bare ground to the densest cover. Each such step came with a pooled hazard ratio of 0.96, meaning a 4 percent lower death rate.
Two of the nine studies found no clear link. Tests for publication bias, the tendency for positive results to get into print more easily, showed little sign of it. Studies followed people for 4 to 22 years, and the cohorts ranged from 1,645 people to more than 4.2 million.
All nine studies are observational, so greener neighbourhoods could differ in ways the models missed, though every study adjusted for income or social position. Results varied widely between studies, and NDVI counts green leaves without saying whether anyone can reach a park. Only one study came from a country outside the high-income group. The authors also assumed a straight-line relationship that they say is unlikely to hold exactly.
The authors pooled the 0.96 figure so that city planners can turn a planned rise in greenery into an estimated number of deaths avoided. It was built to be reused. pubmed.ncbi.nlm.nih.gov/3177…
Adrian Covic retweeted
Everyone knows the mitochondria is the "powerhouse of the cell." But have you seen how beautifully its movement was captured by Dr. Patrick C. Hickey in this 5th place #SmallWorldInMotion winning video? 🏆 Now you have!
bit.ly/3TgEWKn
Adrian Covic retweeted
Fifty-five observational studies including over 7 million patients were analyzed. Statin use significantly reduced the risk of dementia compared to nonusers (hazard ratio [HR] 0.86; 95% confidence interval [CI]: 0.82 to 0.91; p<0.001). It was also associated with reduced risks of AD
Rosuvastatin demonstrated the most pronounced protective effect for all cause dementia among specific statins (HR 0.72; 95% CI: 0.60 to 0.88). The findings underscore the neuroprotective potential of statins in dementia prevention. Despite the inherent limitations of observational studies, the large dataset and detailed sub group analyses enhance the reliability of our results. @nationallipid @foundationofnla @society_eas @ASPCardio @FamilyHeartFdn @fhpatienteurope #statins
Adrian Covic retweeted
In 1976 a Sydney doctor asked in print whether the new cooking oils were causing melanoma. His reasoning was simple. The sun had not changed. What the people were made of had.
Hunters lived naked on the African savannah for 2 million years, on the equator, under the same sun all day.
Egyptian labourers dragged limestone up the pyramids in a loincloth, in 45 degree heat.
Greek athletes trained and competed stark naked at Olympia, in August, from dawn to dusk.
Medieval families brought in every harvest of their lives with their faces, necks and arms turned to the July sun for 14 hours a day.
Nelson's sailors worked the rigging stripped to the waist in the Caribbean.
The palest people on earth, Scots and Irish, were shipped to Australia and cleared the bush by hand, under a sun their skin had never met.
The Anzacs dug trenches at Gallipoli with their shirts off. Bondi Beach in 1935 was shoulder to shoulder with fair-skinned Australians, and the only thing anybody rubbed on was coconut oil.
Not one of them owned a bottle of sunscreen, and melanoma was a medical curiosity. As late as the 1930s an American's lifetime odds were 1 in 1,500. Today they are nearer 1 in 50.
The sun did not get 30 times stronger in 90 years. The fat changed. Sunflower, soybean and corn oil replaced butter and dripping, and linoleic acid began building up in human tissue, including the fat in and under the skin. Linoleic acid oxidises under ultraviolet light. Butter and dripping hold firm. In the lab, the more corn oil the mice were fed, the more skin tumours the same lamp produced.
Australia never took up the question. In 1981 it launched a cartoon seagull telling everyone to slop on sunscreen.
B. S. Mackie kept measuring. By 1987 the linoleic acid in Sydney's body fat had climbed well past its 1975 level, and the melanoma patients carried significantly more of it than the people without.
Sunscreen sales have risen every decade since the seagull. So has melanoma. Office workers now get more of it than farmers and fishermen, who are in the sun all day.
The sun has been up there for 4.5 billion years. Seed oil has been in the human diet for just over a century. Only one of them was ever put on trial.
Adrian Covic retweeted
The American Society of Nephrology comes close to generating it’s own Nephrology guidelines. This could be an effective counterweight and check on Pharma-and KOL-
influenced guidelines (who, OK, 😒are heavily Pharma created, promoted, and funded).
I was assured they couldn’t afford this! LOL.
How can nephrologists better integrate cardiovascular, kidney, and metabolic care? New ASN guidance offers practical recommendations for CKM risk assessment, treatment, and multidisciplinary care for people living with kidney diseases. kidney.pub/KN1809-04 #ASNKidneyNews
Adrian Covic retweeted
MIT published a brutally honest report on what AI is doing to students.
A committee of professors and students spent five months studying how AI changed learning on campus, and the findings read like a warning to every university on the planet.
Study groups are disappearing. Office hours are emptying out. Problem sets and take-home exams no longer prove anything, because AI can produce credible solutions to almost any written assignment in the undergraduate curriculum. Students who lean on chatbots lose mastery and confidence, and some slip into what the report calls cognitive surrender, reaching for AI at the first hint of struggle.
The numbers are rough. 46 percent of surveyed MIT undergrads use LLMs daily. 90 percent worry about their own overreliance. Undergrads who feel AI makes them replaceable now outnumber those who feel it makes them capable.
The committee's answer surprised me. They refused to fight AI with surveillance. The report calls AI detectors unreliable, says lockdown browsers feel like spying, and warns that policing students builds a classroom atmosphere of mutual distrust.
Instead, MIT wants to rebuild education around the things AI can't replace. That means oral exams, semester portfolios, in-person project work, and a required social component in every subject. The report even floats the idea of rethinking grades entirely, since without a GPA to optimize, much of the incentive to cheat with AI evaporates.
The committee warns professors against replacing undergrad research assistants with AI agents just because they're cheaper, because a university exists to grow people, not output.
The most famous tech school on earth admitted the machines broke its way of teaching. Its answer is more humans, not more software.
Adrian Covic retweeted
You’re about to place a femoral arterial line. Is this (arrow) an artery or a vein?
Some people say, “Just use pulsed-wave Doppler.” If you’re one of them, it's the thread 👇
#POCUS #Nephpearls #CriticalCare
Adrian Covic retweeted
"A survey conducted by a major European think tank reveals a worrying finding: 70 percent of respondents view the EU negatively. Skepticism is particularly high in France, Germany, and Italy."
70 Prozent Ablehnung – dieses Votum ist ein verheerendes Zeugnis für Europa to.welt.de/BGhzMwW

































