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Will Yashar

@will_yashar

Physician-scientist in training @OHSUKnight | computational biology | epigenetics | leukemia | @MIT ‘15 | views are my own (he/him)

 Portland, OR
Joined November 2021
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Photo by Will Yashar (@will_yashar)Photo by Will Yashar (@will_yashar)Photo by Will Yashar (@will_yashar)Photo by Will Yashar (@will_yashar)Photo by Will Yashar (@will_yashar)Photo by Will Yashar (@will_yashar)Photo by Will Yashar (@will_yashar)Photo by Will Yashar (@will_yashar)Photo by Will Yashar (@will_yashar)Photo by Will Yashar (@will_yashar)
I'm thrilled to share that our work on Priori is now available on @iScience_CP sciencedirect.com/science/ar…
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Thank you so much to the co-first author of this work, @JoeyEstabrook , as well as the co-authors @theconfluence_, Julia Somers, Olga Nikolova, @ozgunbabur, @DrTedPBraun, and Emek Demir.
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#AcademicTwitter #Bioinformatics #ComputationalBiology #BreastCancer #Leukemia
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Out today! We create a CML potential landscape from time-series whole transcriptome data and use math modeling to predict disease onset and treatment response from a single pre-disease time point. (1/2) nature.com/articles/s41375-0… #scicomm #mathonc @cohmathonc
Image from David.Frankhouser (@D_Frankhouser)
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Also excited to welcome @amara_pang to the lab--she's a super talented MD/PhD student who comes to us with a passion for hematopoietic development and heme malignancies!! 🎁🎁🎁
Image from Julia Maxson (@juliamaxson)
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Trilled on ending 2023 strong with publication demonstrating role of IL1 mediated inflammation on myeloid bias in Premalignant cells, targeting IL1 suppresses/delays myeloid bias, identified transcriptomic/epigenetic mechanisms regulating lineage skewing, nature.com/articles/s41467-0…
Image from Anupriya Agarwal Lab (@LabAgarwal)
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Don’t miss, Happening today Session 509 at 4:30 pm meeting room SDCC room 7, presentation from Mona M.Hosseini from @LabAgarwal @OHSUKnight, describing the role of inflammation in RUNX1 FPD abstract achievement award.
Image from Anupriya Agarwal Lab (@LabAgarwal)
Anupriya Agarwal Lab (@LabAgarwal) profile pictureAnupriya Agarwal Lab@LabAgarwal7 Dec 2023
Ready for @ASH_hematology, Don’t miss oral presentation by Mona M.Hosseini, a passionate grad student @LabAgarwal @OHSUKnight, describing the role of inflammation in RUNX1 FPD, won abstract achievement award. We r also expanding our team, interested candidates DM & we can meet
Image from Anupriya Agarwal Lab (@LabAgarwal)
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I’m honored that our article was selected as an Editor’s Pick in the July issue of @MCR_AACR!
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FLT3 mutations are common in acute myeloid #leukemia (#AML). @will_yashar et al. show that LSD1 inhibition enhances and FLT3 inhibition by disrupting the MYC blood super-enhancer— bit.ly/3HyMe2T @bmcurtiss @DanColeman83 @jake_vancampen @OHSUKnight
Image from Molecular Cancer Research (@MCR_AACR)
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Our work on the mechanism of dual FLT3 and LSD1 inhibition has been released in print by @MCR_AACR! Follow this link to check it out: aacrjournals.org/mcr/article…. #Leukemia #AACR23 #AcademicTwitter
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This work wouldn't have been possible without the collaborative efforts of @bmcurtiss (co-first author), Dr. Coleman, @jake_vancampen, @KongGarth, @JommelMacaraeg, @JoeyEstabrook, @emekdemir, Daniel Bottomly, @WonderMixTape, Dr. Tyner, Dr. Druker, @juliamaxson, and @DrTedPBraun.
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Replying to @will_yashar @MCR_AACR
In this work, we showed that combined LSD1 and FLT3 inhibition disrupts regulatory binding at the MYC blood super-enhancer and results in the accumulation of H3K9me1 methylation at MYC target genes.
Image from Will Yashar (@will_yashar)
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#GoPeaks is now available on @MultiQC for users to visualize peak counts on CUT&Tag and CUT&RUN epigenetic data. Thrilled to contribute to #opensource code in #Genomics and #Bioinformatics 🎉 🎉 🎉
Image from Garth Kong | Computational Biologist (@KongGarth)
Image from Garth Kong | Computational Biologist (@KongGarth)
MultiQC (@MultiQC) profile pictureMultiQC@MultiQC8 Jan 2023
New release! @MultiQC version 1.14 just hit the shelves, and it's a big one! 🎉 Massive thank you to everyone who contributed (there were a lot of you!) 🙇🏻‍♂️ github.com/ewels/MultiQC/rel… Here's a short thread covering some of the highlights.. 🧵
Release MultiQC Version 1.14 · MultiQC/MultiQC

Release MultiQC Version 1.14 · MultiQC/MultiQC

MultiQC new features Rewrote the Dockerfile to build multi-arch images (amd64 + arm), run through a non-privileged user and build tools for non precompiled python binaries (#1541, #1541) Add a new...

github.com
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This made me way more excited than what was probably warranted. That said, this means that Priori will be available on conda-forge! github.com/ohsu-comp-bio/reg… #ComputationalBiology #AcademicTwitter
Image from Will Yashar (@will_yashar)
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Priori is now available on conda-forge! It already has been downloaded 176 within two days of being uploaded 🙌 if Priori is appropriate for your work, give it a try and let us know if you run into any trouble! #ComputationalBiology #AcademicTwitter
Image from Will Yashar (@will_yashar)
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This may be the most satisfying lot number I’ll ever see in my scientific career #AcademicTwitter
Image from Will Yashar (@will_yashar)
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New paper out this week from talented @OHSUKnight graduate student @BreannaManiaci_! (1/x) haematologica.org/haematolog…
Image from Julia Maxson (@juliamaxson)
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End of the year win for GoPeaks: 500+ downloads after 5 months post-publication! Download GoPeaks to call sensible peaks in your CUT&RUN/CUT&Tag/ATAC-Seq data. Hope it continues to serve you throughout 2023! #Bioinformatics #Genomics
Image from Garth Kong | Computational Biologist (@KongGarth)
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