So proud to have been part of this work on cellular rejuvenation through identity-preserving reprogramming, out now in @NatureAging! Grateful to my mentors @geochurch @amplesa and all of our co-authors. nature.com/articles/s43587-0…
Our paper is out in @NatureAging. We looked for factors that make old cells' gene expression young without erasing their identity. SRSF1 came out as a promising rejuvenation target that reduced aging hallmarks in human cells and extended median lifespan of aged mice by 14%.
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ALT Watercolor-style graphic of two overlapping cells split by a curved diagonal. On the left, a muted gray cell with a dark nucleus and faint white circuit traces. On the right, the same form in luminous blue, its circuitry lit up. Short dashes standing for RNA transcripts scatter loosely in gray on the left and fan outward in blue and pale green arcs on the right. Art by Helen H. Wang.
My review on scRNAseq of diabetic wounds and our evolving understanding of fibroblast heterogeneity was published in this month's issue of @Biomed_MDPI! Grateful for wonderful mentors @LongakerLab mdpi.com/2227-9059/12/11/253…
Excited to share my undergraduate work! Thankful to have learned so much from my mentors @geochurch and @amplesa and the rest of our fantastic team.
Can we reverse aging?
7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, biorxiv.org/content/10.1101/… we used 🧬 screens to find new rejuvenation factors🧵1/8
Helen Wang retweeted
Follow VitaDAO fellow @wanghelenh doing amazing research on skin wound healing.
"Thanks VitaDAO for supporting my participation at the CSHL 2022 Mechanisms of Aging meeting where I presented my exciting project "Cellular rejuvenation for skin wound healing"! #cshlaging"
