@voss_lab

Biochemistry/cell biology research group @kieluni | proteolytic processing of Golgi enzymes and Golgi organisation | PI tweeting | now mainly at bsky

 Kiel, Germany
uni-kiel.de/Biochemie/voss
Joined February 2022
  • Tweets35
  • Following141
  • Followers66
2Media
My lab in Kiel, Germany, studies the regulation of #glycosylation in the #Golgi apparatus and we are still looking for a motivated PhD student. Please spread the word/get in touch! Deadline: May 1st. #glycotime #SPPL3
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We are recruiting: ERC- and DFG-funded PhD positions in Tumor Biology (Kiel, Germany). We look forward to your application!
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Our latest paper describing a role for SCAF1 in promoting RNAPII elongation is online at Nucleic Acids Research @NAR_Open! Check it out here: doi.org/10.1093/nar/gkae1219. Big thanks to collaborators @erhard_lab, @MYCGyvers and AG Schlosser!

Phenotypic screens identify SCAF1 as critical activator of RNAPII elongation and global transcrip...

Abstract. Transcripts produced by RNA polymerase II (RNAPII) are fundamental for cellular responses to environmental changes. It is therefore no surprise t

academic.oup.com
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Don't miss the 2025 Gordon Conference on "Lysosomal Diseases" in California (March 2 - 7, 2025)! grc.org/lysosomal-diseases-c…
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Nikita Sergejevs @NickoSunway123, Pedro Carvalho & team find that that the intramembrane protease SPP conducts topology surveillance of CYP51A1 by initiating quality control of incorrectly inserted molecules. Highlight: journals.biologists.com/jcs/… Article: journals.biologists.com/jcs/…
Proposed model of CYP51A1 recognition by SPP. In cells, the lanosterol demethylase CYP51A1 can exist in two distinct conformations, with only one conformation being recognized for membrane protein quality control. The early recognition event by SPP consists of an N-terminal cleavage within the AH of the substrate. This generates a truncated version of CYP51A1 that is subsequently recognized by the RNF185–MBRL E3 ubiquitin ligase complex, extracted from the ER membrane and degraded by the cytosolic proteasomes. APH, amphipathic helix.

ALT Proposed model of CYP51A1 recognition by SPP. In cells, the lanosterol demethylase CYP51A1 can exist in two distinct conformations, with only one conformation being recognized for membrane protein quality control. The early recognition event by SPP consists of an N-terminal cleavage within the AH of the substrate. This generates a truncated version of CYP51A1 that is subsequently recognized by the RNF185–MBRL E3 ubiquitin ligase complex, extracted from the ER membrane and degraded by the cytosolic proteasomes. APH, amphipathic helix.

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Our final 2024 issue! Highlight: New players in lysosomal sorting via mannose-6-phosphate mRNA deadenylation & decay relations Plant ALBA proteins facilitate m6A reading and lots more! Cover: Grishma Rane @GrishTweets, Dennis Kappei @denniskappei et al embopress.org/toc/14602075/4…
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Interesting paper by Verkerk et al. further supporting that loss of #SPPL3 can lead to tumour immune evasion. onlinelibrary.wiley.com/doi/…

Tumor‐Expressed SPPL3 Supports Innate Antitumor Immune Responses

Tumor and immune cells interact through receptor–ligand interactions. B3GNT5 produces nsGSL on tumor cells which is regulated by SPPL3. When SPPL3 is absent, elevated nsGSL levels hinder receptor–l...

onlinelibrary.wiley.com
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Great collaboration with the @voss_lab out now in EMBO Journal! Congratulations Matthias for this nice work!
The EMBO Journal@embojournal2 Dec 2024
GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway Sabrina Jabs, Matthias Voss et al embopress.org/doi/full/10.10…
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Our new manuscript has been published in eLife. We describe a new method for identifying suitable E3 ligases for PROTACs. Many thanks to everyone involved. pubmed.ncbi.nlm.nih.gov/3964…

Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced...

The development of proteolysis targeting chimeras (PROTACs), which induce the degradation of target proteins by bringing them into proximity with cellular E3 ubiquitin ligases, has revolutionized...

pubmed.ncbi.nlm.nih.gov
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GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway Sabrina Jabs, Matthias Voss et al embopress.org/doi/full/10.10…
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GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway | The EMBO Journal embopress.org/doi/full/10.10…

GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate...

The EMBO Journal - Glycosylation, which plays an important role in modifying lipids and sorting of proteins, is regulated by asymmetric intra-Golgi distribution and SPPL3-mediated cleavage of Golgi...

link.springer.com
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Out now: Our collaborative #Golgi #glycotime story, which shows (i) that B4GALT5, a Golgi enzyme, is subject to M6P tagging and (ii) that GOLPH3/GOLPH3L stabilize LYSET and the GlcNAc-phosphotranferase complex and thus are crucial to cellular M6P tagging. tinyurl.com/jkv26nhh
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New review on the proteolytic cleavage of #Golgi enzymes and its impact on cellular glycosylation #glycotime #Golgi #SPPL3 doi.org/10.1016/j.bbagen.202…
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I'm hiring! Interested in lysosomal biology and/or lysosomes and neurodegeneration? The Damme lab is recruiting PhD students and PostDocs! DM or tinyurl.com/yrv4bh22 Get in touch with me! Repost & spread the word!
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We are recruiting: ERC- and DFG-funded PhD positions in Tumor Biology (Kiel, Germany). We look forward to your application!
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Happy Golgi Day
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Sekine group is recruiting for curious minds! 🧬🧫🧪🔬Please apply or spread the word 🗣️ ki.varbi.com/what:job/jobID:…

Forskningsassistent inom T-cellbiologi / Mänsklig immunologi

Vill du bidra till en bättre hälsa för alla? Sekine-gruppen söker en motiverad forskningsassistent för laborativ- och teknisk support. Vår forskning fokuserar på att karakterisera mekanismerna

ki.varbi.com
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Exciting and comprehensive paper - and notably another study that underscores the physiological relevance of SPPL3
Olli Dufva@ollidufva12 Dec 2023
Our resource on NK cell - cancer interactions is now out in @ImmunityCP cell.com/immunity/fulltext/S… We identify tumor-induced NK cell states at single-cell resolution and tumor-intrinsic resistance mechanisms using CRISPR functional genomics Explore: immunogenomics.shinyapps.io/… 1/
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Finally managed to find time for another round of #cytosis with the lab.
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Congratulations to Neele and Stefan on their recent paper in BBA Mol Cell Res, glad we could contribute authors.elsevier.com/c/1hGJO…
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