Senior Investigator Scientist @MRC_LMB Structural Biologist
Cambridge, UK
Joined May 2020
- Tweets288
- Following368
- Followers369
- Likes1.4K
Vish Chandrasekaran retweeted
The Pitchiaya lab is #hiring! We seek to hire a #Postdoc to work on exciting projects pertaining to stress response mechanisms in cancer - bit.ly/46jzBE8. Email/DM for more info. @UMichPath @UMRogelCancer @umichrna @UMichResearch @umichmedicine
Vish Chandrasekaran retweeted
The last time @MRC_LMB team won the interdepartmental cricket cup John Walker was playing in the side! (1982 we think.) Great game against Chemistry, very close!
Vish Chandrasekaran retweeted
We’re excited to share our study in @CellCellPress on the role of the MAP3 kinase ZAK in UV-induced apoptosis led by @2primehydroxyl! We studied cell signaling kinetics following UV-damage and found that ZAK drives apoptosis via ribosome collisions. cell.com/cell/fulltext/S0092…
Vish Chandrasekaran retweeted
We have optimized a human in-vitro translation system (HITS) for use in #ribosome research
Our HITS:
🧪requires a minimal number of components
💵is cheap & easy to prepare
💡enables cap-dependent translation
📈is highly active
online now: bit.ly/49xTdVa
@CellRepMethods
Vish Chandrasekaran retweeted
🥳Thrilled to share our new paper describing Balon, a bacterial ribosome hibernation factor that resembles aeRF1 family proteins. Fantastic collaboration with Karla Helena Bueno @SergeyVMelniko1 and @mariia_rybak @gagnon_lab
nature.com/articles/s41586-0…
Vish Chandrasekaran retweeted
I am thrilled to share our new paper published in @NatureSMB (Brito Querido et al., 2024). #CryoEM structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A.
#Ribosome #mRNA #Science
nature.com/articles/s41594-0…
Vish Chandrasekaran retweeted
A small molecule degrader of the translation termination factor eRF1 = a metal-dependent molecular glue on ribosomes
Learn more here! rdcu.be/du2ZX
Vish Chandrasekaran retweeted
I am thrilled to share our manuscript published in @NatRevMCB.
In this Review (Brito Querido et al., 2023), we discuss the current state of knowledge on eukaryotic translation initiation and its regulation in health and disease.
Now Online The molecular basis of translation initiation and its regulation in eukaryotes dlvr.it/SzkZPh
Vish Chandrasekaran retweeted
A subset of polytopic membrane proteins, such as subunits of the GABAA receptor, remains incompletely inserted when translation is terminated. We describe an essential post-translational step that completes insertion of such proteins. nature.com/articles/s41594-0…
Vish Chandrasekaran retweeted
We have some very exciting projects on mechanisms of DNA repair in the lab! Come join our team 🧬!
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Vish Chandrasekaran retweeted
Available now - the Review "#Cotranslational sorting and processing of newly synthesized proteins in eukaryotes" from Martin Gamerdinger and Elke @DeuerlingLab.
#NacentpolypeptideAssociatedComplex #SignalRecognitionParticle #RibosomeAssociatedComplex
authors.elsevier.com/a/1i0Wg…
Vish Chandrasekaran retweeted
Excited to see fruits of a huge community effort! Thanks to @ProfMilenkovic for the leadership and the opportunity to be a part of this 🙌🏽
Our review+perspective paper on "Current and future directions in network biology" is online (arxiv.org/abs/2309.08478). This has been a Herculean effort by many co-authors, thank you all! Special thanks to @marinkazitnik, @_michellemli, @aydin_wells, and all section coordinators.
Here's a NSMB Research Briefing summarising this work, with @lapassmore
rdcu.be/dlvyE
(Also visit Poster 99 tomorrow at the Protein synthesis and translational control EMBL conference #EMBLprotein)
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Vish Chandrasekaran retweeted
Excited to share our latest work on @biorxivpreprint! We visualised single molecules of dynein and its cofactors live in the axon. Work by @AlexFellows1 in collaboration with the @sangerinstitute (Andrew Basset, Michaela Bruntraeger and Thomas Burgold)
biorxiv.org/content/10.1101/…
Vish Chandrasekaran retweeted
So happy to finally be able to share my post-doc work! I just want to say a massive thank you to everyone who has helped/supported me during this project.
Excited to share our latest work on @biorxivpreprint! We visualised single molecules of dynein and its cofactors live in the axon. Work by @AlexFellows1 in collaboration with the @sangerinstitute (Andrew Basset, Michaela Bruntraeger and Thomas Burgold)
biorxiv.org/content/10.1101/…
Vish Chandrasekaran retweeted
🚨Out now!🚨 Check out how cells adjust their tubulin mRNA levels in response to excess free tubulin. A 40-year-old puzzle solved! Wonderful collaboration with @AbsmeierEva, @lapassmore & @Ivana_Gasic 🧵 1/
cell.com/molecular-cell/full…
Vish Chandrasekaran retweeted
Wonderful collaboration with @FilipovskaLab reveals secrets of non-canonical translation termination in mitochondria. Structural insights and ribosome profiling explain how mtRF1 recognizes noncanonical stop codons in human mitochondria. @ScienceMagazine
science.org/doi/10.1126/scie…
Vish Chandrasekaran retweeted
Absolutely mind blowing talk from @alanbrownhms about the beautiful structures of axonemes! I thought I had a lot of structures to build but his team’s work really puts it into perspective! @ccp_em #cryoEM
