@ule_lab

Welcome to the RNA networks lab! @TheCrick and @UKDRI at King's in London and @kemijski in Ljubljana 🇪🇺

ulelab.info/
Joined August 2020
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3Media
Honoured to have written this review with Jernej Ule’s lab on the splicing code, spanning modeling, mechanisms and its implication for therapeutics designs. Wonderful teamwork.
Nature Reviews Genetics@NatureRevGenet2 Oct 2024
From computational models of the splicing code to regulatory mechanisms and therapeutic implications go.nature.com/4gPju63 #Review by @tiny_captain, @OscarWilkins16, @nils_f_wagner, Julien @gagneurlab & Jernej @ule_lab @HelmholtzMunich @TU_Muenchen @TheCrick @KingsCollegeLon
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How can cellular signalling swiftly & selectively remodel the transcriptome to drive biological transition? How this switch is orchestrated has been a mystery... 🧵 nature.com/articles/s41594-0…
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An opinion piece on how phosphorylation of intrinsically disordered domains selectively alters global protein–RNA binding profiles. sciencedirect.com/science/ar…
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💡Opportunity for a Lab Technician to join Prof Jernej Ule's lab (@ule_lab)! Join Dr Owen G. James (@owengwydz) and a team of researchers working on the roles of ribonucleoprotein complexes (RNP) and their defects in neurodegeneration👉buff.ly/48r4nei
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Last few days to go.... please RT
TheSibleyLab@TheSibleyLab23 May 2022
We’re advertising an exciting post-doc @EdinburghUni integrating #scRNAseq & #hIPSC motor neurons to screen for novel small molecules targeting #MND. Come join us in this amazing city & great research centre. Apply by 10.6.22: bit.ly/3NAcqel @EdinUniNeuro @SBSatEd
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Great opportunity to join our team (@FrattaLab) working on an innovative new gene therapy for ALS/FTD. A mix of novel computational (incl. new machine-learning approaches), molecular & cellular biology, all with a real therapeutic aim. Get involved! Link: tinyurl.com/bddjtjvc
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Wahoo!! Read on for some v. cool insights into how YTH proteins function... in yeast the lone YTH protein is loaded at chromatin & travels to cytoplasm where it helps to couple decay of targets to active translation 👯‍♀️
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Check out our latest preprint entitled “An RNA-binding switch drives ribosome biogenesis and tumorigenesis downstream of RAS oncogene”, out now on @biorxiv: biorxiv.org/content/10.1101/… (1/9)

An RNA-binding switch drives ribosome biogenesis and tumorigenesis downstream of RAS oncogene

Oncogenic RAS signaling reprograms gene expression through both transcriptional and post-transcriptional mechanisms. While transcriptional regulation downstream of RAS is relatively well-characteri...

biorxiv.org
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Chromatin-contact atlas reveals disorder-mediated protein interactions and moonlighting chromatin-associated RBPs academic.oup.com/nar/advance…

Chromatin-contact atlas reveals disorder-mediated protein interactions and moonlighting chromatin...

Abstract. RNA-binding proteins (RBPs) play diverse roles in regulating co-transcriptional RNA-processing and chromatin functions, but our knowledge of the

academic.oup.com
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TODAY, 12h, for our #CEDOCSeminar we will have @PauloGameiro8 from @ule_lab @TheCrick to talk about "Metabolism & RNA modifications in gene regulation". 🧑‍🔬👨‍🏫 Don't miss it! DM us for the Zoom link 📬🙌
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Replying to @ule_lab
@ule_lab jbc.org/article/S0021-9258(2… Latest, a 13C-based assay to quantify the turnover of base modifications in newly transcribed RNA, by mass spectrometry. We uncover the origin of RNA modifications in digested RNA, and assess their sensitivity to metabolic stresses.

Metabolic turnover and dynamics of modified ribonucleosides by 13C labeling

Tandem mass spectrometry (MS/MS) is an accurate tool to assess modified ribonucleosides and their dynamics in mammalian cells. However, MS/MS quantification of lowly abundant modifications in...

jbc.org
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After an extremely long time, members of @ule_lab are enjoying an in-person conference in Vienna @viennabiocenter. What a feeling! 🤗 @paraspeckle @martinahallegg1
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Condensates on transposon(-derived) transcripts and regulation of TDP43-RNA interactions. exciting Transposon-RNA biology by Jernej Ule #EMBOMobileGene
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Replying to @TheCrick @CellCellPress @ule_lab @martinahallegg1 @mndassoc @ucl
🗨️ "Coming from a background in fundamental research, I was thrilled to apply this skill set to some foundational questions in the field of motor neurone research." Find out more about @martinahallegg1's work and the value of @mndassoc support ⤵️ mndresearch.blog/2021/06/24/…

Driving MND Research through our Senior Non-Clinical Fellowships

Reading Time: 6 minutesEach year, MND Associations across the globe mark 21 June as a special day of recognition, acknowledging the impact that MND has on people around

mndresearch.blog
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Congratulations to Dr @JulieQLin, a Research Fellow of Clare Hall, who has been recognised as an Emerging Leader in #dementia research by @UKDRI. Learn more via our news story 💡⬇ clarehall.cam.ac.uk/news/08-… #clarehallcam
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Postdoc position open on ALS gene therapy and RNA splicing, in London! Get in touch if you want to work on novel approaches to correct UNC13A and other splicing alterations induced by TDP-43 pathology: jobs.ac.uk/job/CFN389/resear… @UCLIoN @UCLBrainScience @mndassoc #MND
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ule_lab retweeted
UCL News@uclnews19 May 2021
"We may have found the key to regulating the production of a whole range of proteins involved in brain function & the development of these devastating conditions": Scientists @UCLIoN on breakthrough @Nature study, paving the way to new #dementia therapies ucl.ac.uk/news/2021/may/new-…

New insight into protein production in brain could help tackle dementia | UCL News

A pioneering new study led by UCL scientists has revealed, for the first time, a layer of genetic material involved in controlling the production of tau; a protein which plays a critical role in...

ucl.ac.uk
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ule_lab retweeted
Joyce Yu@joyz_yu18 May 2021
Join us LIVE tonight 8pm and bring your own pint! You'll be hearing from @TerezaClarence @biologicarce @ule_lab @AshleyLibby12 (As the producer of the show, I'll be busy pressing buttons 'backstage' 👩‍💻) #pint21 Register for the YouTube link: pintofscience.co.uk/event/dn…
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Agostini, @ule_lab, Luscombe & co have analyzed public RNA-seq data to look at intergenic transcripts. 80% are read-through transcription from the upstream gene, and most of the rest are lncRNAs. Most are degraded by either XRN2 or the exosome genomebiology.biomedcentral.…
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New pre-print from @FrattaLab @WardLab_NIH! Common ALS/FTD risk variants in UNC13A exacerbate its cryptic splicing and loss upon TDP-43 mislocalization biorxiv.org/content/10.1101/… Explainer thread below!

Common ALS/FTD risk variants in UNC13A exacerbate its cryptic splicing and loss upon TDP-43...

Variants within the UNC13A gene have long been known to increase risk of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two related neurodegenerative diseases defined by...

biorxiv.org
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